@DNARepliLab

News and progress from the DNA replication & genome stability group.

 Norwich, England
oridb.org/dnareplicationgroup/
Joined January 2016
  • Tweets135
  • Following51
  • Followers674
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Delighted to share our pre-print identifying human DNA replication initiation sites on single molecules by @nanopore sequencing. Key findings 1/6 biorxiv.org/content/10.1101/…

Most human DNA replication initiation is dispersed throughout the genome with only a minority...

The identification of sites of DNA replication initiation in mammalian cells has been challenging. Here, we present unbiased detection of replication initiation events in human cells using BrdU...

biorxiv.org
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DNA Replication Lab retweeted
Earlham Institute@EarlhamInst14 Nov 2024
🧬 Do you want to learn how to use @nanopore sequencing to detect DNA base modifications? Our new course will include experimental design with important considerations for generating ultra-long #Nanopore #sequencing reads. okt.to/mO7ogt

Detection of DNA base modification using nanopore sequencing 2025

In this comprehensive two-day course, participants will learn how to use nanopore sequencing to detect DNA base modifications.

earlham.ac.uk
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DNA Replication Lab retweeted
Yasu Daigaku@DaigakuYasu18 Sep 2024
I visited @CNieduszynski in Norwich, UK, and enjoyed discussions with many members of his lab. Many exciting projects are goinig on! Hopefully, we will keep in touch! I also loved the relaxing atmosphere of the city. Thank you for hosting me, Conrad.
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Earlham Institute@EarlhamInst11 Sep 2024
🧬 This morning at @BiochemSoc #DNAReplication meeting in Cambridge, catch Dr Anna Rogers speaking about her work during the 'replication fork progression' session. @DNARepliLab okt.to/qyVfKM
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Replying to @DNARepliLab @nanopore @EarlhamInst
However, most (80%) DNA replication initiation sites are dispersed throughout the genome with no specific chromatin signature and are missed by cell population studies. 5/6
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Great work by Jamie Carrington and Rose Wilson @rhc_wilson collaborating with Sathish @unintegrable and the @EarlhamInst Technical Genomics Group @DrKarimGharbi 6/6
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Earlham Institute@EarlhamInst26 Apr 2024
GUIDE: Learn how to use the #YeastMoClo and #MYT kits from the labs of @johndueber and @ProfTomEllis in a new series of technical blogs from Dr Anna Rogers, for your next budding yeast transformation. 🧬🧫 ➡️ okt.to/NvZiJy @DNARepliLab #yeastgenetics
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Gianni Liti@liti_nice7 Mar 2024
Telomere-to-telomere Schizosaccharomyces japonicus genome assembly reveals hitherto unknown genome features: onlinelibrary.wiley.com/doi/… @Yeast_Journal spoiler: fission yeast will take over the 2024 cover...😱

Telomere‐to‐telomere Schizosaccharomyces japonicus genome assembly reveals hitherto unknown genome...

We present a telomere-to-telomere long-read genome assembly of the Schizosaccharomyces. japonicus genome, which includes the three megabase-length chromosomes, with centromeres hundreds of kilobases...

onlinelibrary.wiley.com
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DNA Replication Lab retweeted
Earlham Institute@EarlhamInst4 Mar 2024
⏰ Applications are closing soon for our Postdoctoral Research Scientist role working on single-molecule analysis of Human #DNAreplication using @nanopore sequencing. 🗓️ Apply by: 07 March 2024 okt.to/agO2V8 #cellbiology #molecularbiology #researchjobs #postdocjobs
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DNA Replication Lab retweeted
Earlham Institute@EarlhamInst29 Feb 2024
We're recruiting for a #postdoc to join the @DNARepliLab with @CNieduszynski at the Earlham Institute. In collaboration with @NIG_idenken you will apply @nanopore sequencing to characterise the dynamics of human genome replication on single molecules. okt.to/NhK5TS
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DNA Replication Lab retweeted
Earlham Institute@EarlhamInst25 Feb 2024
We're recruiting for a #postdoc to join the @DNARepliLab with @CNieduszynski at the Earlham Institute. In collaboration with @NIG_idenken you will apply @nanopore sequencing to characterise the dynamics of human genome replication on single molecules. okt.to/qrMzcL
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New post-doc position: Single molecule analysis of human DNA replication @nanopore sequencing @EarlhamInst Collaborations with ONT and Kanemaki group @NIG_idenken Informal enquiries welcome. Apply here: okt.to/GdXiTM Closes: March 7th Please RT
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Gianni Liti@liti_nice26 Dec 2023
Schizosaccharomyces versatilis represents a distinct evolutionary lineage of fission yeast: onlinelibrary.wiley.com/doi/… #FantasticYeast @DNARepliLab @Yeast_Journal

Schizosaccharomyces versatilis represents a distinct evolutionary lineage of fission yeast

We find that Schizosaccharomyces versatilis diverged from S. japonicus around 25 million years ago and has a reciprocal translocation between chromosomes 1 and 2, which we suggest could form a...

onlinelibrary.wiley.com
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Delighted to have been part of this collaboration: Design, Construction, and Functional Characterization of a tRNA Neochromosome in Yeast with @caiyizhi @DSchindler_PDR @SynbioRoy @JefBoeke @EarlhamInst authors.elsevier.com/sd/arti…
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We have two new fully funded PhD opportunity in our group @EarlhamInst in the @NRPBIODTP 1. Causes and consequences of short tandem repeat instability Join us, @YiliangDing & @WHaerty groups and use @nanopore sequencing to investigate #genomestability t.ly/q5flT
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2. Resolving Nuclear Conflict Join us & @WHaerty group to investigate Transcription-Replication conflicts and #genomestability using @nanopore sequencing. @EarlhamInst @NRPBIODTP t.ly/HE_KH
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DNA Replication Lab retweeted
Graham Etherington@bioinformatiks7 Sep 2023
We're pleased to announce two #fissionYeast pre-prints in collaboration between @EarlhamInst and @TheCrick S. versatilis represents a distinct species doi.org/10.1101/2023.09.04.5… and T2T S. japonicus assembly reveals hitherto unknown genome features doi.org/10.1101/2023.09.04.5…
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