Real world sleep patterns and disease risk from >95,000 @uk_biobank participants @PLOSMedicine 6-8 hours of sleep duration is good and "can effectively reduce the risk of multiple diseases" (but that implies cause and effect, not established ) More REM linked to lower risk of 83 diseases, including dementia, Parkinson's and heart failure More Deep sleep associated with lower risk of 7 diseases, such as Type 2 diabetes and major depressive disorder journals.plos.org/plosmedici…

john sarno is f**king genius this man cured over 100,000 people of back pain, not through stretching, surgery or physical therapy. he cured people through getting them to release their anger. sarno predicted that modern man was going through an epidemic of pain because we have an epidemic of repressed anger. we were all taught that we couldnt feel our anger, because it was dangerous, and this manifests as bodily tension, headaches, IBS and back pain. he is the OG mind-body medicine guy. your emotions control your physical body far more than you realize

Glycine almost completely prevents kidney stones in experiment. People with kidney stones have LOW glycine, & glycine prevents kidney stones in animals by: • Promoting citrate excretion, which binds excess calcium, preventing crystallization • Decreasing oxalate excretion Collagenous cuts FTW

Do not eat these. Discard immediately if you recognize any of these in yours or a loved one’s kitchen, it’s the easiest act of love you can do for them today. A French study in PLOS Medicine examined the impact of emulsifiers (food additives used to improve texture and extend shelf life) on cancer risk. Researchers analyzed data from 92,000 adults over nearly 7 years and found that certain emulsifiers significantly increased cancer risk: Mono & diglycerides of fatty acids (E471)—found in processed baked goods, margarine, and ice cream—were linked to: 15% higher risk of overall cancer 24% higher risk of breast cancer 46% higher risk of prostate cancer Carrageenan (E407 & E407a)—a thickening agent in dairy alternatives, deli meats, and plant-based products—was linked to: 32% higher risk of breast cancer. Cancer is complex and multifactorial, but one thing is certain: the food we eat plays a massive role in shaping our long-term health. Cutting out ultra-processed foods and focusing on whole, nutrient-dense foods is one of the most powerful steps you can take to reduce disease risk. Thank you to my friend Vani Hari for this image + bringing awareness to this critical issue.

I’m a dermatologist. I’m supposed to say there is no amount of safe sun exposure. But I won’t, because that’s a lie. The attached shows how much sun is safe in different cities at different times of year. What do I mean by ‘safe’? I mean this: UV causes DNA damage and skin cancer. But, shockingly, your body repairs that damage. As long as the damage doesn’t outpace repair and start accumulating it shouldn't increase your risk of skin cancer. Data just came out that tells us how much UV you can get without damage accumulating. They took the people most susceptible to DNA damage from UV and exposed them to UV, then did skin biopsies to measure the damage, then more skin biopsies to measure the repair, and repeated it daily for 4 days. At 1.6 ‘Standard Erythemal Dose’ (SED) there was no accumulation of damage. So, the attached charts show how much sun it takes to get 1 SED in different cities at different times of the year at different times of day. And there are extra safety margins built in. It assumes a perfectly clear day with zero air pollution and that the sun is hitting your skin perpendicularly. Unless you’re laying flat, most sun is hitting you at an angle, which isn’t nearly as intense. But a bigger question you might be asking is ‘Why would a dermatologist be telling you to get sun in the first place?’ Because getting sun reduces your risk of death. Mostly by reducing your risk of heart attacks and strokes. That is very well proven. But it’s also very likely that sun exposure reduces your risk of autoimmune disease, dementia, cancer and depression. It’s just not as well proven as the protection against heart attacks and strokes. And before you reply and say ‘just take vitamin D!’, know that it has been ROBUSTLY proven that vitamin D has little (if any) benefit for preventing any of the above. Vitamin D is mostly useful as a marker of if you’re getting enough sun. What do I do myself and what do I tell my patients? Get as much unprotected sun exposure as you can without getting a burn. That’s my GUESS as to what has the best risk/benefit ratio. Dying of skin cancer is actually really rare, especially when compared to the risk of heart attacks, strokes, autoimmune disease, dementia and other cancers. But I’ll admit it’s not for sure best to get as much sun as possible, since sun does increase the risk of skin cancer and it might be the case the benefits plateau at a low level. So, if you’re really worried about skin cancer stick to the charts. The best science I can find says that amount won’t cause skin cancer. The takeaway? Sun is good for you, just don’t get a burn.

D.C. is giving itself a hazardous dose of toxins tonight > largest fireworks in U.S. history > dropping 9 metric tons of toxic chemicals on city > air quality 2-8x higher than "hazardous" > toxins 17-57x higher than acceptable levels > chemicals settling into ground, water, food Ave person will inhale: > 81 ug Strontium: deposits in lung tissue > 81 ug Barium: potent gastrointestinal, cardiac toxicant > 27 ug Aluminum oxides: pulmonary inflammation > 27 ug Titanium oxides: pulmonary inflammation > 27 ug Copper: oxidative stress respiratory > 27 ug Antimony, trace compounds: known carcinogen It will be an acute exposure. Also, idk, is there another way to celebrate our 250th?

Two of the most important biomedical breakthroughs came from science of the Gila lizard venom (GLP-1s) and yogurt (CRISPR genome editing). "The system that turned that lizard into a medicine is now being dismantled." "Less support for scientists means strange questions no one will get to chase." gift link nytimes.com/2026/06/20/opini…

One of the most amazing things I’ve ever seen: a standing ovation for the full Daraxonrasib results I feel inspired and energised, to put it mildly — we have a targeted therapy for pancreatic cancer now, and nothing is undruggable anymore

A small randomized trial in patients with metastatic pancreatic cancer found benefit for paricalcitol, a Vitamin D analog nature.com/articles/s43018-0… Good @salkinstitute explainer salk.edu/news-release/from-s…

🧬 New paper out in @Nature! We used CRISPR to selectively kill cancer cells based on a single-letter mutation in their RNA. The story I want to highlight: KRAS — one of the most notorious drivers of human cancer. A short thread on what we found 🧵

Would be shocking if bacteria that cause gum disease also contribute to Alzheimer’s. Either way, to reduce overall inflammation, maintain oral heath by: 1. Flossing daily 2. Using an electric toothbrush 3. Seeing a dentist >2x a year 4. Chewing oral probiotics 🦷🧠💪

I am reminded once again that research matters. My wife’s friend was diagnosed with metastatic ovarian cancer, resistant to our favorite drug Cis/Carboplatin. Genetic testing revealed, among other things, KRAS G12A mutation. She was started on a KRAS inhibitor but unfortunately developed massive myopathy to the point she could barely walk. At that point, she needed bilateral nephrostomy tubes for renal blockage and was given weeks to live. But her mutation panel had also revealed modestly elevated tumor mutation burden (TMB) and CHEK2 mutation, which is involved in DNA damage response. Based on this (though the evidence was limited), she was started on immune checkpoint blockade (ICB) as a last-ditch effort. Since then, her tumors have melted away, and our friend is now strong enough to clear the snow during LAST NIGHT's blizzard in Northeast. Below is a photo she just sent us. I share not just because this is a miracle, but a SCIENCE IN ACTION! #SpartansWill #ResearchSavesLives @MSUMD, @MSU_Medicine, @HFH_MSU_HS