@DLesman
Joined April 2015
  • Tweets41
  • Following111
  • Followers64
Dan Lesman retweeted
David Li@_David_LiSep 22
Excited to share Minerva, our approach using genome language models for biological discovery! Using Minerva, we find that UG27 reverse transcriptase systems encode variable arrays of diverse ncRNAs with a shared structure, each templating a short DNA hairpin. With @garykbrixi.
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Dan Lesman retweeted
Jackson Weir@jacksonweir4Apr 9
We found a surprisingly large technical artifact hiding in a widely-used scRNA-seq technology. In all Flex v1 datasets we’ve analyzed, we see hundreds of DE genes between probe set barcodes. More on why this matters and what to do about it below: biorxiv.org/content/10.64898… (1/n)
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Dan Lesman retweeted
Varun Varanasi@vjvaranasiApr 7
Excited to share my first paper!
This Post is from an account that no longer exists. Learn more
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Come check out some fun ways to use Vault😎 youtube.com/watch?v=AgQdVOMy… science.org/doi/10.1126/scie…

TimeVault - A Genetically Encoded Device for Transcriptome Storage in Mammalian Cells

Notebooklm is crazy lol

youtube.com
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Thrilled to share our newest method for transcriptome recording using TimeVault! science.org/doi/10.1126/scie…

A genetically encoded device for transcriptome storage in mammalian cells

Understanding how cells make decisions over time requires the ability to link past molecular states to future phenotypic outcomes. We present TimeVault, a genetically encoded system that records and...

science.org
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Dan Lesman retweeted
Nic Fishman@njwfish26 May 2025
🚨 New preprint 🚨 We introduce Generative Distribution Embeddings (GDEs) — a framework for learning representations of distributions, not just datapoints. GDEs enable multiscale modeling and come with elegant statistical theory and some miraculous geometric results! 🧵
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Dan Lesman retweeted
HSCRB@HSCRB30 Apr 2024
Congratulations Fei Chen for winning the 2024 Star-Friedman Challenge for Promising Scientific Research for his proposal “Neuromodulatory Effects of Stabilized Endogenous Peptides.” @insitubiology hscrb.harvard.edu/news/fei-c…

Fei Chen Wins 2024 Star-Friedman Challenge for Promising Scientific Research | HSCRB

hscrb.harvard.edu
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Dan Lesman retweeted
Arjun Raj
@arjunrajlab6 Jan 2024
Wow
Scott Coyle@CellRaiser_4 Jan 2024
Replying to @CellRaiser_
Finally, plasmids for tinkering with this system will be on Addgene shortly. If you're excited about this technology or just enjoy psychedelia, grab these reagents and do a transfection--within 24 hours you'll be tripping. We're so excited to see where imagination will take you!
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Every day, UPS drivers deliver a quarter of the U.S.'s parcels out of trucks without air conditioning. As they vote on whether to authorize a massive strike later this summer, heat has become a crucial sticking point. First story for @washingtonpost: washingtonpost.com/business/…

As UPS union plans vote on strike, drivers broil in trucks lacking AC

Heat protection is a key issue as drivers experience severe temperatures at work.

washingtonpost.com
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Dan Lesman retweeted
ODID@ODID_QEH26 Oct 2022
Congratulations to all our students who have won prizes for their performance on our masters' courses in 2021/2022! Well done and we're excited to follow your future achievements. 🎉👏🎓 Check out the details of all prize winners: qeh.ox.ac.uk/news/congratula…
MSc student prize winners for 2022

ALT MSc student prize winners for 2022

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Sharing Photoselective Sequencing (PSS), a new method for genomic and epigenomic measurements within spatial regions of interest. Thanks to the whole team @haiqi_chen, @H3K4me1, @juliedobkin_, @DLesman, @JD_Buenrostro, and Fei Chen. biorxiv.org/content/10.1101/… (1/9).

Photoselective sequencing: microscopically-guided genomic measurements with subcellular resolution

In biological systems, spatial organization is interconnected with genome function and regulation. However, methods that couple high-throughput genomic and epigenomic profiling with spatial informa...

biorxiv.org
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“The Backstreets” is the first Uyghur-language novel to be translated into English. Perhat Tursun’s writing starkly portrays the weight of Chinese state violence on Uyghur souls econ.st/3LcUAxL
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Some #DALLE creations and their captions:
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With its sprawling acreage, Memphis tends to rank low in surveys of U.S. cities with affordable housing shortages. But a closer look shows that housing stock isn't just a matter of quantity. Story for @DailyMemphian: dailymemphian.com/subscriber…

Bucking national trends, affordable housing in Memphis is a problem of quality, not quantity

Even as housing prices are rising substantially in some parts of the area, the value of housing in other areas has been stagnate or even falling.  

dailymemphian.com
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After a six-week abortion ban took effect in Tennessee, Memphis residents likely have to travel more than 200 miles to seek care in Illinois — something Biden's executive order doesn't change. First story for @DailyMemphian: dailymemphian.com/section/me…

Biden executive order unlikely to expand Tennessee's limited abortion access

“The executive order ... protects contraception and providers who are going to be needing to do their jobs to save the women that we’re going to see an influx of,” said one local OB-GYN. “I think...

dailymemphian.com
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100 years before Brown vs Board of Education, a 5 year old Black girl Sarah Roberts attempted to go to her elementary school classroom in Boston before being escorted out by a police officer. An article I wrote for The Emancipator on an ideological battle over education.
The Emancipator@the_emancipator20 May 2022
Harvard University profited from enslaved family of Darby Vassall. Once becoming a freedman, Vassall helped establish the first school for African American students in Boston. bostonglobe.com/2022/05/20/o…
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In college, I started searching for living descendants of the Harvard enslaved. I found 50. All American universities with ties to slavery can find living descendants, and students can lead the charge. If you are/know a student who wants to do this, encourage them to message me.
The New York Times
@nytimes26 Apr 2022
Breaking News: Harvard will spend $100 million to study and redress its ties to slavery, joining other universities confronting their complicity with slavery. nyti.ms/3Kh5wbJ

Harvard Details Its Ties to Slavery and Its Plans for Redress (Published 2022)

The university is committing $100 million for an endowed “Legacy of Slavery Fund.” Its report carefully avoided treading on direct financial reparations for descendants of enslaved people.

nytimes.com
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Our new method, C-SIDE, for cell type-specific DE in spatial tx: biorxiv.org/content/10.1101/… Detects DE in diverse contexts such as space, disease, cellular interactions. Controls for cell type effects and mixing. Led by Dylan Cable and colab w/ @rafalab @macosko @Vignesh_Shan
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Started at the bottom (@broadinstitute 10th floor), now we're here (Broad 11th floor) 🚀 Celebrating the opening of our new lab space with a DIY ribbon cutting ceremony
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So excited to share this paper! Thank you to @woldloren and @TheWoldLab team for the amazing mentorship and support!
Circulation@CircAHA22 Jan 2022
#InDepth #E-cigarettes are increasing in popularity. Explore an in-depth review on potential harms and current use. @woldloren #AHAJournals ahajournals.org/doi/10.1161/…
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