@DJTraderLab

Medicinal Chemistry and Chemical Biology Lab @ UC Irvine

 Irvine, CA
djtraderlab.com/
Joined March 2018
  • Tweets394
  • Following254
  • Followers721
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The immunoproteasome as prodrug target to release MMAE in vivo? Check! Excited to continue to pursue this new drug discovery avenue. Congrats to first author Cody Loy and thank you to our amazing collaborators Claudia Benavente and Lisa Wagar! nature.com/articles/s41392-0…

From probe to prodrug: immunoproteasome activity as a trigger for disease-selective therapeutics

Signal Transduction and Targeted Therapy - From probe to prodrug: immunoproteasome activity as a trigger for disease-selective therapeutics

nature.com
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Excited to share more about the ByeTAC story! New paper in JACS describing the ability of a ByeTAC to degrade CRBN and Rpn13. Congrats to Cody Loy and Shawn Vinogradsky! pubs.acs.org/doi/10.1021/jac…

Two Mechanisms One Molecule: Developing a ‘Truly’ Bifunctional Degrader Targeting Rpn13 and CRBN

Abstract. Targeted protein degradation (TPD) has emerged as a powerful strategy to eliminate disease-relevant proteins, yet current approaches remain large

pubs.acs.org
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Please join us to learn more about applying for a PhD in PharmSci at UCI! uci.zoom.us/meeting/register…
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New degrader paper using the immunoproteasome and degrons! Congrats Cody Loy and Timothy Harris! pubs.acs.org/doi/full/10.102…
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Thrilled to share our new study in @nchembio describing the proteome-wide impacts of electrophile stress in the context of covalent fragments. Big congratulations to first authors Ashley Julio @AshleyJulio4 and Flowreen Shikwana @FShikwana ! 1/5 nature.com/articles/s41589-0…

Delineating cysteine-reactive compound modulation of cellular proteostasis processes

Nature Chemical Biology - A cysteine-reactive degrader of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) nonstructural protein 14 (nsp14) was identified, which mediates degradation...

nature.com
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A new paper from @TheAlbrecht_Lab and @LJSeabrook developed a targeted protein degradation platform, MrTAC, that enables arginine methylation-driven degradation of intracellular proteins in lysosomes doi.org/10.1038/s41589-024-0…
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I’m so excited to welcome MrTAC to the world of targeted protein degradation! We created a chemical inducer of arginine methylation that can be used to degrade proteins in lysosomes 💊 So grateful for everyone involved in this project 🥳🥳 nature.com/articles/s41589-0…

Methylarginine targeting chimeras for lysosomal degradation of intracellular proteins

Nature Chemical Biology - Development of a targeted protein degradation platform, methylarginine targeting chimera (MrTAC), enables arginine methylation-driven degradation of intracellular proteins...

nature.com
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Congrats Cody and Saayak on your immunoproteasome probe paper! chemistry-europe.onlinelibra…

Synthesis and Application of a Versatile Immunoproteasome Activity Probe

The ONX-0914-alkyne probe described here allows for the conjugation to a variety of fluorophores through click chemistry. It can then be used to visualize immunoproteasome activity in gel-based,...

chemistry-europe.onlinelibrary.wiley.com
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Excited to see this happening. Go proteasome stimulation!!! linkedin.com/posts/feleciano…

#biotech #biotechinnovation #proteasomeactivation #neurodegenerativedisease | Diogo R. Feleciano |...

Introducing Booster Therapeutics! I’m very proud to announce the debut of Booster Therapeutics 🚀 With $15M in seed financing from Apollo Health Ventures and Novo Holdings, we are pioneering a new...

linkedin.com
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UC Irvine’s Pharmacological Sciences PhD Program is hosting a VIRTUAL Info Session on Wed, Sept 11 from 12 pm – 1 pm PST. Join us to learn about the Pharmacological Sciences PhD Program, the Admission process, and helpful campus resources. Register: bit.ly/3XhrGTD
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Congrats @CodyLoy45 on your RSC ChemBio paper on a caged luciferin probe for the immunoproteasome! doi.org/10.1039/D4CB00148F

Caged aminoluciferin probe for bioluminescent immunoproteasome activity analysis†

The immunoproteasome (iCP) can be expressed under inflammatory conditions, such as exposure to interferon-gamma (IFN-γ), that alerts the cell to begin gene

pubs.rsc.org
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Congrats @CodyLoy45 on your recent review on the proteasome's primed substrate channel! doi.org/10.3390/molecules291…

Primed for Interactions: Investigating the Primed Substrate Channel of the Proteasome for Improved...

Protein homeostasis is a tightly conserved process that is regulated through the ubiquitin proteasome system (UPS) in a ubiquitin-independent or ubiquitin-dependent manner. Over the past two decades,...

mdpi.com
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Trader Lab retweeted
Cody Loy@CodyLoy4514 Jun 2024
Had an amazing experience at my first Bioorganic Chemistry GRC! From the exciting talks to making some incredible friendships, I can’t wait to go back to science summer camp. 🧪🏕️ Oh, and winning an outstanding poster award wasn’t too bad either!
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Huge congrats to these FIVE amazing PhD candidates in the lab! Cody Loy, Kate Kragness, Tim Harris, Duno Dantis, and Jaida Osman
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We have an opening for a #chempostdoc in the @DMHuryn lab to work on our med chem / chemical biology kidney disease project. For more info - and contact info: web.sas.upenn.edu/hurynlab/
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Discover the secrets to PhD success! 🥼🔬 Listen to @TheAlbrecht_Lab on her tips to becoming a successful PhD student at @UCI_SPPS. #UCISPPS #UCIPharmSci #FuturePhD #PhDStudent #GradSchool
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Congrats Candidate Cody!
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The @OnoPharmaFound sponsors a terrific series of Webinars in #chembio and this upcoming one will be excellent. Please retweet to get the word out.
ONO PHARMA FOUNDATION@OnoInitiative13 Mar 2024
Join us for the 8th #chemicalbiology webinar featuring Dr. Michelle Arkin (UCSF), who will present on "Molecular glues for 14-3-3sigma/CRAF as potential probes and drugs for Noonan’s Syndrome" Apr 17, 4:30PM-5:30PM PT, Zoom For free registration, visit onofound.org/events/michelle…

Michelle Arkin, PhD, University of California San Francisco, Webinar

The Ono Pharma Foundation was established to support academic research in relevant scientific fields, which have the potential of making significant impact on therapeutic approaches to disease and...

onofound.org
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When your trainees have too much time on their hands, they make your lab into proteasome people!
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The wendtlab.com/ is looking for postdocs interested in collaborative work in breast cancer metastasis, novel therapeutics, and the tumor microenvironment. @uiowa @UIowaCancer @IntMedatIowa offer a great environment of translational research. rb.gy/yfonfc
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