MD Neurologist, Autoimmune Neurology & Neuroimmunology program HCVB. Romance languages student, Poet & Polyglot 🇨🇱🇫🇷🇮🇹🇬🇧 Onconeural antibodies 👨⚕️
Viña del Mar
Joined July 2021
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Dr.Fernandezcar retweeted
Thank you @anaselgenidy1
The session was great with several discussions around immune reset, naive vs memory B cell roles post immunotherapy and CAR-T therapy.
Excellent presentation by Dr. Irani @Mayo_AING at #ANA2026 on a fundamental question in neuroimmunology: What causes autoimmunity in humans?
Fascinating insights into how central and peripheral immune tolerance shape CASPR2-directed autoimmunity.
#Neuroimmunology #AutoimmuneNeurology #Neurology #MayoClinic
Dr.Fernandezcar retweeted
Excellent review article on MOGAD MRI Imaging.
Congratulations to all the authors.
Delighted to share our international review on MRI Characteristics of #MOGAD! ➡️ Key imaging features are highlighted across the brain, optic nerves & spinal cord including lesion dynamics ➡️ Illustrative figures help show its full imaging spectrum👇
jamanetwork.com/journals/jam…
Dr.Fernandezcar retweeted
Gran hito en neuroinmunología 🧠: Se ha creado el Premio Weiner para honrar los 50 años de investigación del Dr. Howard Weiner en Esclerosis Múltiple (EM) e interacciones neuroinmunes. El premio inaugural de 2025 fue otorgado al Dr. Lawrence Steinman. 🧵👇
Dr.Fernandezcar retweeted
This retrospective cohort study with a preplanned analysis found that prednisolone ≥10 mg treatment for ≥3 months after the index event was associated with a lower likelihood of relapsing MOGAD: hubs.la/Q04w51LN0
🧠 The “Kiss Swan” sign is a symmetric medullary T2 hyperintensity seen in adult leukodystrophies, particularly Alexander disease (GFAP). It may guide genetic testing but is not pathognomonic. 👌
Dr.Fernandezcar retweeted
Altered EEG in Creutzfeldt-Jakob Disease: Improving Diagnostic Accuracy Using American Clinical Neurophysiology Society 2021 Criteria hubs.la/Q04s1D8-0
Autoimmune Parkinsonism: When Should We Suspect It?
▶️ Antibody-associated disease: only 1.3%.
▶️antibody screening: not recommended.
▶️Red flags: rapid course, inflammatory CSF, atypical MRI, or cancer.
▶️Anti-IgLON5: think sleep apnea, bulbar/neuromuscular signs, or chorea.
Dr.Fernandezcar retweeted
Double-Negative Neuromyelitis Optica Spectrum Disorder: A Systematic Review and Meta-Analysis hubs.la/Q04vqVBQ0
#NMOSD
Dr.Fernandezcar retweeted
This study looked at the incidence of dementia, stroke, epilepsy, and Parkinson disease in older Veterans before and after acute #TBI to determine whether these conditions are bidirectionally associated with TBI: hubs.la/Q04pxH5f0
▶️SCLC with anti-GABABR, anti-Hu, and no PNS showed distinct molecular profiles.
▶️Anti-GABABR tumors were associated with 5q gain and KCTD16 overexpression.
▶️Anti-GABABR showed B-cell signatures, while anti-Hu showed T-cell/IFN-γ signatures.
👌
Dr.Fernandezcar retweeted
Septin autoimmunity has a true queen! 🟢🟢
Congratulations Friederike Arlt at @MayoClinicNeuro and @ChariteBerlin on this outstanding study in @Brain1878 identifying antibodies against the septin complex in lower motor neuron disease, suggesting a potentially antibody-mediated incisuropathy due to septin binding🔝
And you’ve just presented new phenotypes in the expanding field of septin antibodies, including brainstem syndromes, encephalopathies, and myeloradiculopathies, likely reflecting their broad expression throughout the nervous system.
Can’t wait to see what’s next‼️
#StayTuned #Autoimmunity #Neuroimmunology
Dr.Fernandezcar retweeted
ICI-neurotoxicity: long-term outcomes
• Recovery beyond 3 months is rare
• Relapses: 15% mostly year1
• 40% have 1-year sequelae
• Immunosuppression>1 year may be unnecessary
• Only 5% relapsed after rechallenge
Rechallenge appears safe after recovery
jitc.bmj.com/content/14/6/e0…
Dr.Fernandezcar retweeted
Sono lieto di condividere il primo episodio della nuova stagione di #Neuropod della @sinneurologia 🎙️🧠
Focus su encefaliti autoimmuni: diagnosi, esami e strategie terapeutiche, dalla fase iniziale alla gestione a lungo termine.
👉🏼 Guarda il video!
youtube.com/watch?v=FpOiM2MB…
Paraneoplastic myelopathies 👌
➡️Asymmetric weakness, paresthesias, severe neuropathic pain, sensory ataxia, bladder dysfunction, orthostatic intolerance
➡️MRI spine: longitudinally extensive, tract-specific T2 lesions
Most common:
1⃣ Amphiphysin 2⃣ CRMP5 3⃣ Hu
Dr.Fernandezcar retweeted
A positive MOG antibody result does not always mean MOGAD‼️
TRUE MOGAD Score helps neurologists worldwide estimate whether a positive MOG result is truly clinically meaningful.
Proud collaboration between @MayoClinic and @JohnsHopkins
Scan the QR code below to access the tool 👇🏽
It is an honor to contribute to this study.
In anti-NMDAR encephalitis with prolonged disorders of consciousness (≥9 months)
▶️about two-thirds achieved substantial or full recovery over long-term follow-up.
▶️Older age and higher NEOS scores increase mortality
🧠👌
Privileged to contribute to research on NMDA encephalitis with prolonged disorders of consciousness.👌
🚀 We are sharing our last work! Complications, outcomes, and implications of a prolonged vegetative state in anti-NMDA receptor encephalitis: a retrospective international cohort study
thelancet.com/journals/laneu…
Remote attendance at the outstanding Neuroimmunology & Autoimmune Neurology course by Clinic Barcelona.
Insightful discussions on stiff-person syndrome, autoimmune encephalitis, and anti-IgLON5 disease.
#Neuroimmunology #AutoimmuneNeurology #IgLON5 #StiffPersonSyndrome
Dr.Fernandezcar retweeted
⚡New #PNS study!
In a population-based cohort of 878 patients evaluated for suspected @paraneoplastic syndromes, alternative diagnoses were common, especially in patients <55 and those without high-risk syndromes. The PNS DDx Score was developed⬇️
👉 : link.springer.com/article/10…
This constitutes a significant diagnostic challenge, particularly in neuromuscular disorders, where many paraneoplastic phenotypes are non-classical and often overlap with other neurological conditions.
⚡New #PNS study!
In a population-based cohort of 878 patients evaluated for suspected @paraneoplastic syndromes, alternative diagnoses were common, especially in patients <55 and those without high-risk syndromes. The PNS DDx Score was developed⬇️
👉 : link.springer.com/article/10…