@CuriousGenome

Biology, Tech and and all things Longevity science. Targeting longevity escape velocity.

 Norway
Joined June 2026
  • Tweets65
  • Following73
  • Followers9
holding a grudge is like drinking poison and waiting for the other person to die
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My dear friends, I am happy to report the publication of the most important paper in my life to date (we have several great papers coming out but this is very special). Tomorrow, I will present this paper for the first time at the Nature AI Healthcare in Paris and will post a longer post on this story and its broader implications for how to conduct clinical trials. Please read it and comment on it. Many thanks to the great co-authors of the study and everyone who contributed. Many thanks to the many reviewers (friendly and unfriendly) for spending so much time and helping make it better. Link in the comments.
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I was extraordinarily fortunate to have early access to @OpenAI Astra. After what I've seen, I believe we've now reached one of the defining milestones in the age of AI & have clearly crossed the threshold of AGI! Astra left me so profoundly awestruck that I am struggling to explain what I experienced! Hope to share more soon! The stars have aligned. A new AI era has begun. ✨💫
🤖 Made with AI
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Leo Voss retweeted
Lifespan
@JoinLifespanAug 25
It’s Yamanaka Day
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Most people that checks for heart health measures Vo2, LDL and ApoB. But they should add VLDL, MRI and the ratio between triglycerides and HDL (should atleast be 2:1 or way lower)
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I love the sun and red light, but hate breakage in my DNA. Sunscreen for the win
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Few things you can do have as profound an impact on your health and well-being as resistance training. 💪 This image says it all. Lift weights. Build muscle. Invest in your future self. Shoutout to @AFaigenbaum for creating the original image that inspired this adaptation.
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The problem with truth is, once you see it, you can’t unsee it.
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Chronic low-grade inflammation (metaflammation) is a common pathway for most age-related disease. Diet quality, body composition, sleep, and psychological stress all feed into it. Pick the levers you can actually pull.
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You can track dozens of biomarkers and still miss the simplest ones: resting heart rate trends, grip strength, how you feel after a night of real sleep, and whether you can still play with kids without getting winded.
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The goal isn’t to die at 120 feeling like a carefully maintained machine. It’s to stay capable, clear-headed, and engaged long enough that the extra years actually feel like life rather than maintenance. But I want more. LEV <3
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Which type of exercise is better for improving cardiometabolic health: aerobic training or resistance training? The answer: They are complementary. Our new meta-analysis indicates that aerobic and resistance training provide distinct benefits that work together to produce a synergistic effect on cardiometabolic health. Bottom line: It doesn't have to be an either-or decision. Do both. Kudos to @alexbatrakoulis for spearheading the paper 💪 jssm.org/jssm-25-637.xml-Ful…
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Resistance training 2–3× per week remains one of the highest-ROI habits for both healthspan and cognitive function. The dose-response curve is steep at the beginning and still positive decades later.
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My hardships in life has helped me being a more complete, robust and compassionate person.
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Curiosity is a longevity trait. People who keep learning new physical and cognitive skills tend to maintain higher function longer. The brain rewards novelty with resilience.
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Mitochondrial function declines with age. Exercise is still the most reliable way we know to keep more of them working. No pill currently matches the signal from regular physical work. Yet.
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NAD+ boosters, resveratrol, metformin, rapamycin… the list grows faster than the human data. Interesting signals exist. Strong clinical proof of meaningful lifespan extension in healthy people does not (yet). But I hope they will soon.
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Most “anti-aging” supplements have way weaker evidence than simply sleeping 7–8 hours and lifting weights twice a week. The boring basics still outperform the expensive stack.
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For christmas I want my own CRISPR lab.
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Leo Voss retweeted
nature
@NatureJul 24
Scientists have exploited a peculiar CRISPR enzyme so that it fights cancer by shredding the DNA in cancer cells. go.nature.com/4yFEZz5

Bizarre CRISPR enzyme kills cancer cells by shredding their DNA

Nature - Early tests suggest the protein can be aimed at targets with tumour-causing mutations.

nature.com
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Here's a curious (and somewhat unexpected) observation from my HBOT experience: my knees have completely stopped cracking. This is puzzling. The popping or cracking sound in joints is generally attributed to cavitation and the rapid formation and collapse of small nitrogen gas bubbles within the synovial fluid when the joint capsule is stretched or pressure changes occur. Do the pressurized oxygen somehow have an effect? Curios anecdote at least. #HBOT #Longevity
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