Analyst on therapeutics (CNS).Neuronal plasticity. BDNF lover and amateur painter🎨 #biopharma #therapeutics
New York, NY
Joined January 2012
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Start the year learning about TrkB and mGluR5 teaming up in the hippocampus, choreographing synaptic changes. BDNF and G-protein-dependent crosstalk lead the intricate dance of receptor crosstalk. Thanks to everyone that made it possible #trkb #gpcr doi.org/10.1016/j.celrep.202…
I am happy to share a pre-print about my project at at Dr. Francis Lee's Lab on a novel form of synaptic plasticity. Please don’t be shy and share your feedback. All this work was possible to an amazing team, thanks to @JihyeKimMD and the rest of the team
biorxiv.org/content/10.1101/…
1. Our research describes a new RTK/GPCR crosstalk wherein mGluR5 amplifies TrkB effects to modify downstream signaling dynamics, leading to a unique form of BDNF-induced synaptic plasticity.
1. The identified crosstalk between TrkB and mGluR5 is facilitated through the cooperative action of Gbg, released from TrkB, and Gaq-GTP, released from mGluR5. This represents a novel and physiologically significant form of RTK/GPCR crosstalk.
2. This interplay results in a distinct form of BDNF-induced synaptic plasticity characterized by sustained, oscillatory Ca2+ signaling and enhanced MAP kinase pathway activation.
Proud to be part of this team 🥰
During #MHAM, I honor the countless hours of my lab team. We take a multidisciplinary approach to studying the function and dysfunction of neural circuitry with a particular focus applying this work to the progression & treatment of psychiatric disorders. Thank you!
Cristina Lao-Peregrin retweeted
A class of #Alzheimers drugs that aims to slow cognitive decline, including the antibody lecanemab that was granted accelerated approval in the United States in January, can cause brain shrinkage, researchers report. scim.ag/23J
Cristina Lao-Peregrin retweeted
Happy International Women's Day!
We're celebrating women who have changed the world. Here's all of the amazing women who have received the #NobelPrize and their remarkable achievements at the time of the award.
Who are the women who inspire you the most?
#IWD2023
Cristina Lao-Peregrin retweeted
Honored and excited to take on this Chair and advance our understanding of the relationship of physical and emotional trauma to mental health.
#UCalgary announces Dr. Matthew Hill as inaugural Chair of Mental Health Initiative for Stress and Trauma, exploring how the brain reacts to physical and emotional stressors ow.ly/SwrU50MsSxh @HotchkissBrain @UCalgaryMed @UofCr4kids
Cristina Lao-Peregrin retweeted
#UCalgary announces Dr. Matthew Hill as inaugural Chair of Mental Health Initiative for Stress and Trauma, exploring how the brain reacts to physical and emotional stressors ow.ly/SwrU50MsSxh @HotchkissBrain @UCalgaryMed @UofCr4kids
Cristina Lao-Peregrin retweeted
Congratulations to Dr. Francis Lee on his appointment as the new interim Stephen and Suzanne Weiss Dean of Weill Cornell Medicine! @wcmresearch #weillcornellmedicine #werechangingmedicine
Cristina Lao-Peregrin retweeted
Anthony Fauci has become one of the most recognizable physician-scientists in the world.
For a new #ScienceEditorial, @hholdenthorp sat down with the outgoing #NIAID director to talk about the challenges facing science and his plans for the future. scim.ag/Qg
Cristina Lao-Peregrin retweeted
Please RT. #Postdoc and Research Tech positions open @RajadhyakshaLab to study #addiction in animal models. Genetics, molecular, circuits, behavior. DM me.
Cristina Lao-Peregrin retweeted
🔴 Irrespirable + peligroso el aire y humo ahora mismo en Granada 😷
#Incendio #Granada #Guajares
@JuanMa_Moreno a qué espera para poner soluciones urgentes lo antes posible???? Hoy decreta el nivel 1 cuando el incendio está descontrolado desde hace dÃas. Qué vergüenza de gestión, qué auténtica vergüenza.
Cristina Lao-Peregrin retweeted
Epstein-Barr Virus May Be Leading Cause of Multiple Sclerosis
The risk of developing mutliple sclerosis increases 32 fold following Epstein-Barr virus infection.
#multiplesclerosis #neuroscience #science #neurology
neurosciencenews.com/epstein…
Cristina Lao-Peregrin retweeted
A new Science analysis of data from U.S. military recruits suggests multiple sclerosis—a disease considered of unknown etiology—is a complication of infection with Epstein-Barr virus.
Learn more ⬇
fcld.ly/sicotxm
#SciencePerspective: fcld.ly/ehqno7q
Cristina Lao-Peregrin retweeted
A pyramidal tract neuron in frontal cortex. That apical dendritic tuft 🔥. from Lingxiao Shao in the lab. Happy #FluorescenceFriday !
