@CreekLab

The Creek laboratory at Monash Institute of Pharmaceutical Sciences uses advanced metabolomics and systems pharmacology to investigate drug action in pathogens

 Melbourne, Victoria
creek-lab.com/
Joined February 2016
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The latest paper from our lab identified extracellular metabolites of Pseudomonas aeruginosa correlated with ceftolozane/tazobactam-resistant subpopulations and modelled the time-courses of these metabolites @JessTait_PKPD @CreekLab @CRE_RESPOND journals.asm.org/doi/10.1128…

Identifying and mathematically modeling the time-course of extracellular metabolic markers associ...

Antibiotic resistance is a serious threat to global health and a particular burden for vulnerable patient populations such as those with cystic fibrosis (CF) or the critically ill (1). The optimiza...

journals.asm.org
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Call for Abstracts for Metabolomics 2024! Complete details online: metabolomics2024.org/abstrac… Deadline for oral abstracts is March 7. #metabolomics
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Replying to @CreekLab
@CreekLab & MIPS team introduces Orbitrap Astral MS for faster throughput, higher sensitivity, & deeper proteome coverage. Supported by a $3m grant from the Medical Research Future Fund, the platform fosters collabs among institutions & industry partners. monash.edu/pharm/about/news/…
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We got our baby boy (Orbitrap Astral) @CreekLab, the entire @thermofisher team is at @MIPS_Australia. Can't wait to analyse samples @Monash_MPMF. Open to nickname suggestions.
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Couldn't be prouder of @Nathan_NguyenTN accomplishment, congratulations to my first PhD graduate. @NikVeldhuis @MIPS_Australia
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I'm super excited to share the results of our phase 2 randomised clinical trial using gut microbial metabolites to lower #bloodpressure, for now as a pre-print @VicHeartInst @MonashBiol @Monash_Science @MonashUni Funded by @heartfoundation @nhmrc A 🧵 medrxiv.org/cgi/content/shor…
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Congratulations Doctor @MatthewChallis8 on graduation today. The end of a great chapter and the start of a successful career! @MIPS_Australia
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Very proud of Stanley Xie who was awarded a University of Melbourne Award for Excellence in Mid-Career Research Achievements.
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Nice review of omics-based drug target identification methods for malaria drugs published by @MatthewChallis8 @MIPS_Australia doi.org/10.1016/j.ijpddr.202…
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Great to see a full house @MIPS_Australia for the #viin_yis watching the next generation of @The_VIIN infection & immunity research stars #Globalhealth_TPA
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Just published - ex vivo evaluation of 12 repurposed drugs for COVID lnkd.in/eu_HhFJk Nature Portfolio's highlight lnkd.in/e_gaCXgh of our paper on repurposing method lnkd.in/gvxZkimD Thank you to great team, including @ssvasan @CreekLab @CarlkRx

LinkedIn

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lnkd.in
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New work ranking top repurposed drugs for COVID Led by @ssvasan @CreekLab @CarlkRx Chris MacRaild, Ian Styles, Amanda Peterson @MIPS_Australia Faheem, Muzaffar, Murugesh @bitspilaniindia Anu Kumar, Alex McAuley @CSIRO Enzo Palombo @Swinburne Thanks @Sue_Dunlevy
Vasan@ssvasan14 Oct 2022
Replying to @MonashUni
@MonashUni’s @NatalieTrevaski & Darren in @Sue_Dunlevy’s national @newscomauHQ coverage of our #CovidIsntOver work mdpi.com/1422-0067/23/19/118… “Although we haven’t quite said X marks the spot, we’ve narrowed down the search area to top 200 or so candidates” medianowadays.news/dozen-dru…
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Honoured to be awarded @arc_gov_au future fellowship #FT22 to study malaria parasite metabolism!!! This is only possible thanks to my amazing team and many collaborators. @MIPS_Australia #GlobalHealthTPA
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CreekLab retweeted
PMV@PMV_Australia1 Aug 2022
Get ready for our Mid-Year Symposium!! Focusing on all things #multiomics and held at @Bio21Institute with some fantastic speakers. Its free AND hybrid, so you really don't have an excuse not to come. Register now at tinyurl.com/mrxsf3y4! #proteomics #metabolomics #lipidomics
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#ASP2022 @G__Siddiqui from @CreekLab just gave an excellent talk about their synthetic ozonides target ID chemoproteomics pulldown and how the drugs perturbed parasite redox homeostasis!
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Agreed. Well done to Stanley, @LeannTilley and the whole team. Glad to contribute our 2c on metabolite ID, but happier to see how industry and academia can work together to discover new malaria drugs (with a cool mode of action)
Griffin Lab@The_GriffinLab3 Jun 2022
Fantastic to see this work identifying a new antimalarial strategy published. Proud and privileged to lead the structural biology with a global team headed up by Prof. @LeannTilley. Congratulations to all involved! @UniMelb @Bio21Institute @TakedaPharma science.org/doi/epdf/10.1126…
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MIPS #GlobalHealthTPA will be hosting a symposium & networking event this Friday at @MonashPharm on "Repurposing Medicines for #GlobalHealth". Registration essential forms.gle/BshWQhG9BJrGcu1R7
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Excited to share our story on glutaminase inhibition in #KRAS-mutant #lungcancer - out today in @Cell_Metabolism! This couldn't have been possible without @sarahannbest & collaborators from @WEHI_research @AgiosPharma @TheDohertyInst @MonashPharm 👇👇
Cell Metabolism@Cell_Metabolism2 May 2022
New! Glutaminase inhibition impairs CD8 T cell activation in STK11-/Lkb1-deficient lung cancer dlvr.it/SPdCCs

Glutaminase inhibition impairs CD8 T cell activation in STK11-/Lkb1-deficient lung cancer

Best et al. investigated the metabolism of KRAS-mutant lung adenocarcinoma and found that STK11/Lkb1 co-mutation (KL) results in increased glutamate and glutaminase. Glutaminase inhibition (CB-839)...

cell.com
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Excited to share my research on #lungcancer #metabolism - online today in @Cell_Metabolism authors.elsevier.com/sd/arti… Here’s the gist 🧵1/5 @CellPressNews @Sutherland_Lab @WEHI_research #OpenAccess #cancer #immunology #LCSM
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A #proteomics resource to aid research of parasite biology, pathogenesis, and drug and vaccine discovery in malaria. A new mass spectral library for high-coverage and reproducible analysis of the Plasmodium falciparum–infected red blood cell proteome doi.org/10.1093/gigascience/…
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