DFG funded Collaborative Research Centre 1430 "Molecular Mechanisms of Cell State Transitions" @unidue @unidue_zmb
Joined May 2021
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Wrapping up the year with our @crc1430 Female Scientist Get-Together Christmas Special! 🎄✨ At the Christmas Market, we’ll revisit this year’s highlights and brainstorm new topics for 2025. 👩🔬 Here’s to another year of connection and growth! #WomenSupportWomen #Networking #STEM
Congrats to @MalteGersch and the @GerschLab on their new publication in Nature Chemical Biology @nchembio! 🎉 Fantastic work on #USP53 #DUB #ChemicalBiology!
🔗 nature.com/articles/s4158
Very excited to share that our manuscript on the "Discovery and mechanism of K63-linkage-directed deubiquitinase activity in USP53" was published today at Nature Chemical Biology @nchembio. Congratulations Kim, Kai, and all authors! nature.com/articles/s41589-0…
Tomorrow, November 26, we are looking forward to hosting @georg_e_winter from @CeMM_News, Austrian Academy of Sciences, Vienna, at @crc1430 @unidue. Join us for his exciting talk on small-molecule degraders!
CRC 1430 retweeted
Join us for the next talk in our "Sex and Gender in the Life Sciences" series. Sandra Iden from @Saar_Uni will be presenting online today at 5:15 pm.
▶️udue.de/Sexgenderude
#SexGenderUDE #sexandgendersensitive medicine
We're happy to welcome Sandra Iden @iden_lab from @Saar_Uni to our @crc1430 and 'Sex and Gender in the Life Sciences' seminar series @unidue tomorrow, October 29th. Looking forward to an insightful talk—see you there! #SexGenderUDE #SexAndGenderInBiologyAndMedicin
Congratulations to our @CRC1430 members from the #PaschenLab and colleagues on their publication 'Long non-coding RNA GRASLND links melanoma differentiation and interferon-gamma response' in @FrontiersIn. #GreatJob! #Melanoma #Interferonγ #Research frontiersin.org/journals/mol…
Today‘s @crc1430 female scientist get-together was all about real stories and practical advice! 💫Special thanks to our guest Manuela Kowalczyk for sharing her experiences and sparking insightful discussions on navigating a career in #STEM 👩🔬#WomenSupportWomen #Networking
Excited to share a new paper from @GolgiLabEssen, published in @RoySocChem: 'Induced degradation of SNAP-fusion proteins'! A great collaboration within @CRC1430 with #KaiserLab and #ACE!! #SNAPPROTACs #FantasticCollaboration
🚨 Publication alert from the Hellerschmied Lab‼️
Interested in adding SNAP-PROTACs to your molecular toolbox? Then take a read! Congratulations to all the authors on this exciting work!
@GolgiLabEssen @unidue_zmb @crc1430
pubs.rsc.org/en/content/arti…
Congrats to @CRC1430 members from @GerschLab @MalteGersch on their new @biorxivpreprint! Fantastic work on USP30 inhibition via chimeric deubiquitinase engineering and DUB ligandability. Check it out! #USP30 #DUB #StructuralBiology
Interested in Ubiquitin, Parkinson’s disease therapy, mitochondria or DUB inhibitors? This preprint may be for you:
We show how the deubiquitinase USP30 can specifically be inhibited & introduce a framework for DUB ligandability.
biorxiv.org/content/10.1101/…
Thread👇 – with movie!!
Congratulations to our @CRC1430 members from @LabWestermann and their collaborators on their latest preprint @biorxivpreprint! Check out their exciting work! Fantastic job! #Kinetochore #MitoticErrorCorrection #MolecularGenetics
We are excited to share our latest work in context of the colaborative research consortium 1430 @Crc1430. A preprint is available on bioRxiv (doi.org/10.1101/2024.10.01.6…).
We are excited to highlight the new publication from our @CRC1430 members @MusacchioLab @AndreaMusacchi1 in @ScienceMagazine: "Role of protein kinase PLK1 in the epigenetic maintenance of centromeres." Fantastic work! science.org/doi/full/10.1126… #Research #Epigenetics #Centromeres
We are excited to announce the new publication from our @CRC1430 members @hemmo_lab in @PNASNews: #VCPp97 regulates PP1 beyond biogenesis! Fantastic work by the team! #Biochemistry #Research #FRET
Out in PNAS: #VCPp97 regulates PP1 beyond biogenesis! It maintains a steady-state between a thermodynamic sink for PP1 and active holophosphatases. Great work by Anja et al. using FRET and reconstituting PP1 holophosphatase formation. In vitro veritas.
pnas.org/doi/10.1073/pnas.24…
Congratulations to our @CRC1430 members @GatsogiannisLab on their new lab preprint @biorxiv! This work reveals unprecedented aspects of the elevator-type transport mechanisms of the UapA purine transporter. #HighResolution #CryoEM #Research
📢New lab preprint: 2.05 A #cryoEM structure of UapA: unprecedented aspects of the elevator-type transport (incl. water, lipids) and regulatory roles of the N-tail. With Diallinas, Mikros labs. Kudos @broutzakis and all co-authors. @uni_muenster #SoN
biorxiv.org/content/10.1101/…
We're thrilled to announce a new preprint from our @CRC1430 member @MalteGersch and the @GerschLab on two novel active DUBs and a unique type of DUB activity! Check it out! #Deubiquitinases #ChemicalBiology #Research
For all ubiquitin, deubiquitinase and chemical biology aficionados:
Here's a preprint from the lab introducing 2 new active DUBs in humans & a unique type of DUB activity one would miss with the widely used panels of free ubiquitin chains.
t.ly/GnRVv
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Congratulations to our @CRC1430 member @MartinPSchwalm and colleagues from the Knapp Lab on the publication of tracerDB in @NatureComms! #Research #FluorescentTracers #DisplacementAssays #Science
Authors including @MartinPSchwalm announce tracerDB, a curated database of fluorescent tracers- protein ligands required for various displacement assays.
nature.com/articles/s41467-0…
We’re excited to highlight the work of @MartinPSchwalm, our @CRC1430 member from the Knapp Lab, and colleagues on the functional characterization of pathway inhibitors for the ubiquitin-proteasome system (UPS) as tool compounds for CRBN! #Ubiquitin #Proteasome #Biochemistry
Functional characterization of pathway inhibitors for the ubiquitin-proteasome system (UPS) as tool compounds for CRBN and ... biorxiv.org/cgi/content/shor… #biorxiv_biochem
Proud of our @crc1430 PhD students for their exciting talks and the engaging scientific discussions at this year's PhD symposium. Thank you to everyone who made this event a tremendous success! #PhDResearch #ScienceInAction
On September 18th, our @crc1430 Female Scientists Get-Together returns! 💬✨ Every six weeks, this #WomenInScience event provides a valuable platform for our female members to exchange strategies and discuss career development. #Networking #WomenInSTEM
