An allosteric cyclin E-CDK2 site mapped by paralog hopping with covalent probes dlvr.it/TDdBNg

Selective Covalent Inhibiting JNK3 by Small Molecules for Parkinson's Diseases dlvr.it/TDQ5zm

Development of ketalized unsaturated saccharides as multifunctional cysteine-targeting covalent warheads dlvr.it/TDDqbG

From Mechanism-Based Retaining Glycosidase Inhibitors to Activity-Based Glycosidase Profiling dlvr.it/TCpjGx

SuFEx Chemistry Enables Covalent Assembly of a 280-kDa 18-Subunit Pore-Forming Complex dlvr.it/TCglxQ

Targeted Protein Localization by Covalent 14–3–3 Recruitment dlvr.it/TCVVQX

Aminomethyl Salicylaldehydes Lock onto a Surface Lysine by Forming an Extended Intramolecular Hydrogen Bond Network dlvr.it/TCP1hT

Discovery of a Covalent Inhibitor of Pro-Caspase-1 Zymogen Blocking NLRP3 Inflammasome Activation and Pyroptosis dlvr.it/TCCVwB

Discovering Covalent Cyclic Peptide Inhibitors of 2 Peptidyl Arginine Deiminase 4 (PADI4) Using mRNA3 Display with a Genetically Encoded Electrophilic 4 Warhead dlvr.it/TC6Xvf

Electrophilic proximity-inducing synthetic adapters enhance universal T cell function by covalently enforcing immune receptor signaling [@RulloLab] dlvr.it/TBwHWd

Multi-tiered chemical proteomic maps of tryptoline acrylamide–protein interactions in cancer cells [@EvertNjomen] dlvr.it/TBtTfc

Exploring 2-Sulfonylpyrimidine Warheads as Acrylamide Surrogates for Targeted Covalent Inhibition: A BTK Story dlvr.it/TBtTch

Discovery of Thioether-Cyclized Macrocyclic Covalent Inhibitors by mRNA Display dlvr.it/TBsdHB

Predicting the Intravenous Pharmacokinetics of Covalent Drugs in Animals and Humans dlvr.it/TBVMv1

Graph neural networks for identifying protein-reactive compounds dlvr.it/TBQ5VL

Sophisticated natural products as antibiotics dlvr.it/TBN0rk

Identifying pharmacological probes for human proteins represents a key opportunity to accelerate the discovery of new therapeutics. High-content screening approaches to expand the ligandable proteome offer the potential to expedite the discovery of novel… dlvr.it/TBMH5v