Supported by @NIH, the NIH Pragmatic Trials Collaboratory is advancing the design, conduct, and dissemination of pragmatic clinical trials.
Joined October 2012
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🎙️ NOW AVAILABLE: Episode 1 of our 4-part podcast series. Drawing on experience from the NIH Collaboratory Trials, experts share the latest wisdom in designing pragmatic trials that are feasible and capable of producing actionable evidence.
🔗 duke.is/pctpod
📣 In this week's PCT Grand Rounds, @texhern of @DCRINews and @DukeMedSchool will present “Catalyzing Change: How First-in-Patient Trials Can Fix U.S. Clinical Trials.” Join us! #pctgr
🔗 du.ke/pctnews20261013
An analysis of data from the GRACE trial found a mediating role of pain catastrophizing between depression and pain outcomes in adults with sickle cell disease and chronic pain. #nihHEALinitiative
Learn more ➡️ duke.is/pctnews20261012
“EHR-enabled strategies that emphasize patient-centered decision-making and education may reduce opioid exposure while maintaining patient-centered outcomes, reinforcing the ongoing need for patient education to address opioid-related harms,” said Dr. Andrea Cheville.
In the NOHARM trial, published online in @JAMANetworkOpen, a strategy to promote nondrug pain management after surgery reduced exposure to opioids without worsening pain interference, physical function, and other patient-reported outcomes.
Learn more ➡️ duke.is/pctnews20260928
ALT The graphic shows the title page of the JAMA Network Open article alongside headshots of the NOHARM trial's co–principal investigators, Dr. Andrea Cheville and Dr. Jon Tilburt.
In the OPTIMUM study, patients' prior experience with virtual doctor visits influenced their willingness to participate in a telehealth-delivered mindfulness program for chronic low back pain.
Learn more ➡️ duke.is/pctnews20261008.
📣 In this week's PCT Grand Rounds, Christoph Hornik of @DCRINews and Moulik Shah of @MaxisAIInc will present “An End-to-End Agentic AI Platform to Automate Clinical Trials: A Proof-of-Concept and Evaluation Study.” Join us! #pctgr
🔗 du.ke/pctnews20261007
In an article in Frontiers in Pain Research, the APA-SM team describes their approach to engaging patients, clinicians, and healthcare system administrators in codesigning a feasible, culturally relevant pain management program in rural settings. duke.is/pctnews20261006
📣 In this week's PCT Grand Rounds, Diana Higgins and Alicia Heapy of @YaleMed will present “Self-Directed Versus Clinician-Delivered Cognitive Behavioral Therapy for Chronic Pain: Results From the COPES ExTRA Pragmatic Trial.” Join us! #pctgr
🔗 du.ke/pctnews20261002
Join experienced investigators from the NIH Pragmatic Trials Collaboratory to learn essentials of dissemination and implementation in #pragmatictrials in our full-day workshop at @academyhealth's 19th Annual D&I Conference. #DIScience26
Register today! duke.is/pctnews20260929
ALT Register today - Dissemination and Implementation in Embedded Pragmatic Trials: Tools and Strategies for Enhancing Public Health Impact - A workshop at the 19th Annual Conference on Dissemination and Implementation in Health - National Harbor, MD - December 13, 2026
In the NOHARM trial, published online in @JAMANetworkOpen, a strategy to promote nondrug pain management after surgery reduced exposure to opioids without worsening pain interference, physical function, and other patient-reported outcomes.
Learn more ➡️ duke.is/pctnews20260928
ALT The graphic shows the title page of the JAMA Network Open article alongside headshots of the NOHARM trial's co–principal investigators, Dr. Andrea Cheville and Dr. Jon Tilburt.
NIH Pragmatic Trials Collaboratory retweeted
📣 In this week's PCT Grand Rounds, Corey Bills of @CUMedicalSchool will discuss the PACT-ARROW study, which uses a master protocol for trials of prevention and treatment of infected traumatic wounds in hospitalized patients in Ukraine. Join us! #pctGR
🔗 duke.is/pctnews20260921
ALT NIH Pragmatic Trials Collaboratory - Rethinking Clinical Trials Grand Rounds - "Research During Active War in Ukraine: Experiences From the PACT-ARROW Study" - Corey Bills, MD, MPH; University of Colorado
📣 Don’t miss the new 4-part educational podcast series demystifying embedded pragmatic trial design from @Collaboratory1. Episode 1 sets the stage with NCCIH Director Wendy Weber and NIH Collaboratory co-PIs @texhern and Lesley Curtis.
🔗 Listen now: duke.is/pctpod
📣 In this week's PCT Grand Rounds, Corey Bills of @CUMedicalSchool will discuss the PACT-ARROW study, which uses a master protocol for trials of prevention and treatment of infected traumatic wounds in hospitalized patients in Ukraine. Join us! #pctGR
🔗 duke.is/pctnews20260921
ALT NIH Pragmatic Trials Collaboratory - Rethinking Clinical Trials Grand Rounds - "Research During Active War in Ukraine: Experiences From the PACT-ARROW Study" - Corey Bills, MD, MPH; University of Colorado
The NIA IMPACT Collaboratory, a program advancing pragmatic trials of interventions for people living with #dementia, is seeking applicants for its 2027 Health Care Systems Scholars Program.
9/25: Info webinar 🧑🏽💻
11/5: Letter of intent 📩
Learn more ➡️ duke.is/pctnews20260917
📣 In this week's PCT Grand Rounds, @ErikaRangelMD of @harvardmed will present “The 4th Trimester Initiative: A Randomized Controlled Trial of Support for Childbearing Medical Trainees.” Join us! #pctgr
🔗 du.ke/pctnews20260916
📣 In this week's PCT Grand Rounds, @RZarychanski of @umanitoba will present “Embedded Trials in a Learning Health System: A Hospital Policy of Tranexamic Acid to Reduce Transfusion in Major Noncardiac Surgery.” Join us! #pctgr
🔗 du.ke/pctnews20260909
Access our complete collection of pragmatic trials learning modules, videos, tools, workshop materials, and the Rethinking Clinical Trials Grand Rounds archive through our training resources portal.
Learn more ➡️ duke.is/training
In an analysis from the Nudge study, the per-patient cost of text message reminders suggests that medication adherence support via mobile messaging may be a low-cost solution for healthcare systems.
Learn more ➡️ du.ke/pctnews20260903
📣 In this week's PCT Grand Rounds, Haider Warraich of @ARPA_H will present “Evaluating Clinical Agentic AI.” Join us! #pctgr
🔗 duke.is/pctnews20260826
A new article from NOHARM, an NIH Collaboratory Trial, describes strategies and challenges for posttrial sustainment of pragmatic trial interventions. duke.is/pctnews20260825
ALT Headshot of lead author Shrithra Gayathri alongside a screenshot of the article