@ColinYCLee

MB-PhD candidate • Bioinformatics and immunology • @Cambridge_Uni • @Kings_college • @Gates_Cambridge alumnus 🇸🇬🏃🏻⚽️

Joined November 2020
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  • Followers489
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Interested in tumour immunity, dendritic cells and immunotherapy? Excited to share our study on CCR7+ dendritic cells (DCs) in cancer out today, a joint effort between @LabWithers and @ClatworthyLab. (🧵 1/8) nature.com/articles/s41467-0…

Tumour-retained activated CCR7+ dendritic cells are heterogeneous and regulate local anti-tumour...

Nature Communications - Recognition of tumour antigen induces dendritic cell activation and migration to the lymph node. Here, the authors use photoconvertible mice to demonstrate that some...

nature.com
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Colin Lee retweeted
Ines Marin@Ines_Marin_GOct 14
We usually think of #LymphoidStructures as signs of chronic inflammation. But what if some actually protect tissues? 🛡️ Our new preprint reveals how tissue-retained mature dendritic cells (#mDCs) organize regulatory lymphoid niches with age! biorxiv.org/content/10.64898… 🧵 1/6

Tissue retention of dendritic cells drives age-associated protective tolerogenic lymphoid structures

Ectopic lymphoid structures are typically associated with chronic tissue inflammation in autoimmunity and cancer, where they can amplify local immune responses. Similar structures arise spontaneously...

biorxiv.org
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Check out our Opinion paper in @Nature, where we write about: i) The decline in physician-scientist numbers worldwide ii) Why this might be, based on our own data and others’ iii) Steps to reverse the decline nature.com/articles/d41586-0… @rezamotallebov @CharlesSwanton @bealelab

Keep medical doctors in academia — without them, health-care research will suffer

Nature - Better career support and more funding stability is needed to retain this invaluable group of scientists.

nature.com
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THIS IS THE BEST PAPER OF 2026 SO FAR, A MONUMENTAL BREAKTHROUGH, A REVOLUTION IN THE FIELD OF INFLAMMATORY CONDITIONS: Interleukin-10 Autoantibodies and HLA-DRB1*01:03 in Inflammatory Bowel Disease | New England Journal of Medicine nejm.org/doi/10.1056/NEJMoa2…

Interleukin-10 Autoantibodies and HLA-DRB1*01:03 in Inflammatory Bowel Disease | NEJM

Neutralizing autoantibodies against interleukin-10 can result in a phenocopy of monogenic defects of interleukin-10 signaling in children and may be associated with inflammatory bowel disease (IBD)...

nejm.org
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Colin Lee retweeted
KelvinTuong@KelvinTuongFeb 9
Sneak peak of upcoming sc-dandelion 1.0.0 release! Read, process and plot 1M single-cell AIRR data e.g. @ParseBio's data in <15min without GPU! #singlecell #bcr #tcr
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Great to see this really cool piece of work now out in @NatureGenet led by superstar @elizabetha_coop. Check it out!!
Elizabeth Cooper@elizabetha_coopFeb 3
I am excited to share our latest research out today @NatureGenet; here we discovered childhood brain tumours instruct cranial hematopoiesis and identify a clinically relevant mechanism to re-educate the skull bone marrow. nature.com/articles/s41588-0…

Childhood brain tumors instruct cranial hematopoiesis and immunotolerance

Nature Genetics - Antigen presentation in skull bone marrow by hematopoietic stem and progenitor cells induces myelopoiesis and generates CD4+ regulatory T cells in a mouse model of ependymoma,...

nature.com
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Very excited to share our latest preprint – We find that childhood brain tumours instruct cranial haematopoiesis allowing immunotolerance of childhood brain tumours and CNS development. A thread 1/11 biorxiv.org/content/10.1101/… @Gilbertson_Lab @CRUK_CI @LPTrustUK @BrainTumourOrg
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PSA: Stop calling macrophages in tissue M1 or M2. These are not states that exist in biology. The only use of M1 is a macrophage cultured ex vivo with LPS and IFNg; and for M2: IL-4/13/10. Macrophages in tissues are highly complex and diverse and do not resemble either of the aforementioned M1/M2 states. M1/M2 language causes confusion and sets the field back. Refer to your macrophages by the molecules they express and the cytokines they make.
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In Vivo Labeling Resolves Distinct Temporal, Spatial, and Functional Properties of Tumor Macrophages and Identifies Subset-Specific Effects of PD-L1 Blockade doi.org/10.1158/2326-6066.CI… @ColinYCLee @ClatworthyLab and @LabWithers
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Our latest study using the photo-convertible Kaede model to track tumour-infiltrating leukocytes and their changes over time is now out in @CIR_AACR! doi.org/10.1158/2326-6066.CI… @ClatworthyLab @LabWithers
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We identify spatially, temporally and functionally distinct tumour-associated macrophage (TAM) populations that undergo rapid changes following tumour infiltration. Immune checkpoint therapy promotes pro-inflammatory IFNγ-driven responses in newly-entered monocyte-derived TAMs.
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If interested, do also check out our previous related work using the Kaede model to study the temporal dynamics of *DCs* (doi.org/10.1038/s41467-024-4…), *NK cells* (doi.org/10.1038/s41467-024-4…) and *T cells* (doi.org/10.1084/jem.20210749); review article (doi.org/10.1111/imcb.12787).
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We have a PhD position opening for Australian domestic students interested to work at the intersection of immunology, data science, and paediatrics! Check out the full description here! linkedin.com/posts/ian-fraze… @YUmmunology

Single cell technology and its application in immune-related diseases in children | Ian Frazer...

🎓 PhD Opportunity with up to $10,000 Ian Frazer Centre Top-Up Scholarship – Paediatric Immunotherapy at the Ian Frazer Centre The University of Queensland is offering a fully funded PhD opportunity...

linkedin.com
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CHOIR is now online @NatureGenet! CHOIR is a new clustering method for single-cell data that evaluates whether clusters represent statistically distinct cell populations. CHOIR scales to millions of cells and works with single-/multi-omic data of any type! nature.com/articles/s41588-0…
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Thank goodness people are waking up to the fact that there is a crisis for clinical research in the UK @FT High on the list are the bureaucratic processes that have become such an obstacle to getting things done
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Review @jacionline @ClatworthyLab @ColinYCLee Profiling immune cell tissue niches in the spatial -omics era jacionline.org/article/S0091…
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Most rigorous ML paper
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Check out our discussion (@ClatworthyLab) on the use of Spatial Transcriptomics for investigating immune niches in this month's issue of @jacionline
Journal of Allergy and Clinical Immunology@jacionline3 Mar 2025
The March issue of JACI is now online! Check it out here: jacionline.org/current This month's theme focuses on Spatial Transcriptomics. Read the Editors' Choice summaries from the March issue here (free to read/download): authors.elsevier.com/a/1khQa…
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Recent developments in high-throughput spatial -omics technologies have facilitated a more comprehensive understanding of tissue immunity. Learn how they have generated new insights in translational immunology and what the future might hold. bit.ly/41tH15E
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Huge! 🎉🎉
KelvinTuong@KelvinTuong24 Feb 2025
Veryy happy to share that I got lucky this round and was successful in my #NHMRC Investigator Grant! Thanks to my past and present mentors @YUmmunology @ClatworthyLab @teichlab who helped shaped my career thus far!
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Veryy happy to share that I got lucky this round and was successful in my #NHMRC Investigator Grant! Thanks to my past and present mentors @YUmmunology @ClatworthyLab @teichlab who helped shaped my career thus far!
Translational Research Institute Australia@TRI_info24 Feb 2025
Congratulations to TRI-based researchers/clinicians sharing in @nhmrc support to advance work in kidney disease, blood cancer and gut health (pictured from right): @DWJohnsonNeph, @KelvinTuong and @AyeshaShah717. @UQ_News, #FrazerInstUQ, @qldhealth
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