@Cogan_Lab

Exploiting chemical factories and sensors in bacteria for humanity @USC #NaturalProductBiosynthesis #StructuralBiology #Enzymes #SyntheticBiology

 USC, Los Angeles
thecoganlab.weebly.com/
Joined August 2023
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Published in #AngewandteChemieNovit: Sacrificial Methionine Residues Protect Active-Site Histidines from Oxidation by Ronald T. Raines and co-workers. Read it here: onlinelibrary.wiley.com/doi/…
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Check out our paper just published in JBC: jbc.org/article/S0021-9258(2…

C-terminal dimerization motifs control asynchronous chain elongation during modular polyketide...

The rifamycin synthetase (RIFS) from the bacterium Amycolatopsis mediterranei is a homodimeric assembly line that catalyzes 40+ chemical reactions to generate a complex precursor of the antitubercu...

jbc.org
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Check out our new preprint: biorxiv.org/content/10.1101/…

Molecular Basis for Asynchronous Chain Elongation During Rifamycin Antibiotic Biosynthesis

The rifamycin synthetase (RIFS) from the bacterium Amycolatopsis mediterranei is a large (3.5 MDa) multienzyme system that catalyzes over 40 chemical reactions to generate a complex precursor to the...

biorxiv.org
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@PKS_papers @NRPS_papers @biorxivpreprint
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