RNA levels in the liver oscillate during the circadian cycle. This study reveals that not only transcription, but splicing, nuclear export, and cytoplasmic mRNA stability also play a role in generating these rhythms. #circadian #liver bit.ly/3PuWuw9 @PLOSGenetics

Chronic high androgen levels in women with PCOS can cause hepatic steatosis by disrupting the hepatic circadian clock. New research shows underlying mechanisms. #PCOS #androgens #circadian bit.ly/3HlKvig

The gut microbiome regulates host metabolism over the circadian cycle! New research shows that OligoMM12-colonized mice have altered energy storage and fat mass compared to germ-free or fully colonized mice. #microbiome #circadian #energystorage bit.ly/3Hpg62o

This study discovers a small molecule that selectively destabilizes Cryptochrome 1 and enhances lifespan in p53 knockout mice. This molecule could be a promising treatment for forms of cancer depending on the p53 mutation. #cryptochrome #cancer #molecule bit.ly/3YezUeU

Did you ever wonder if bats have functional circadian clocks ticking in their liver? New research shows that they do, and that their liver genes exhibit rhythmic changes throughout the day. #bats #circadian #liver #nocturnal bit.ly/3FDNlxS

Did you know that caloric restriction can induce daily rhythms in blood ketone bodies? New findings show that the circadian clock plays a role in regulating this process. #ketogenesis #circadianclock #caloricrestriction bit.ly/3UKBv9A

Disruption of circadian clock component BMAL1 affects insulin sensitivity and liver disease. This study shows that the circadian clock plays a key role in disease development. #circadian #NAFLD bit.ly/3W759Ha

Aligning caloric restriction with circadian rhythm extends lifespan in male mice by 35%. Time-restricted eating may be key to unlocking the benefits of caloric restriction. #caloricrestriction #longevity #circadian. One of the top 10 clock papers of 2022! bit.ly/3iQ0UkW