Dad, husband, brother, son. Scientist studying lipid metabolism @UKYMedicine. Alumnus🎓 of @UCF🛡️⚔️ and @UAB_GBS🐲🔥. Views are my own.
Kentucky, USA
Joined May 2020
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🚨BIG NEWS🚨 Our lab just secured 5 years of #funding from @NIH #NIGMS! 🎉📰
In a tough funding climate, this support means we can keep pushing our #science forward @UKYMedicine @UKyMIMG.🔬🥼
Immensely grateful to #mentors & #colleagues who helped make this happen. 🤝❤️
🦠New in @PNASNews
Our latest study reveals an unexpected #immune evasion strategy used by #StaphylococcusAureus. We found #OhyA lipids suppress an #antiviral immune pathway (TLR3-TRIF-IRF7), allowing #bacteria to persist in host cells. @NIH @UKYMedicine
pnas.org/doi/10.1073/pnas.26…
Grateful to see our recent #PNAS study gaining attention! 🎉
Thanks to @commsbio and @UKYMedicine for featuring our work on how S. aureus uses host-derived #lipids to suppress innate immune defenses. 🛡
research.uky.edu/news/uk-col…
nature.com/articles/s42003-0…
Christopher Radka retweeted
How do lipids shape immunity? 🧬 This review explores oxylipins 🔬—key mediators of host–microbe interactions 🦠 that regulate inflammation 🔥 & infection, with promising potential for therapeutic targeting 💊
🔗 mdpi.com/1467-3045/47/3/190
🚨New in @Virulence12!🚨
#Staphylococcus aureus🦠isn't just an extracellular pathogen---it survives inside #macrophages during #osteomyelitis. Our review explores how it hijacks🥷 macrophage polarization to persist in #bone 🦴and drive chronic infection. tandfonline.com/doi/full/10.…
🎉New paper out in #Biochemistry @ACSPublications! We reveal how #Staphylococcus aureus rewired a classic #enzyme to escape feedback control 🚧, fueling #membrane biosynthesis and opening doors for bioengineering. @AmerChemSociety @StJudeResearch @UKyMIMG
pubs.acs.org/doi/10.1021/acs…
Grateful to @ASBMB for the opportunity to share our team’s research at #ASBMB25! Excited to highlight our work on #lipids, #structuralbiology, #signaling, #evolution, and #microbialphysiology. @UKYMedicine @UKyMIMG
Bon appétit in @chicago #ChinaTown 🍽. An excellent finish to Day 1 of #asbmb25 ✅️! @ASBMB @SantiagoFrangos #Turbot🐠 #MOSAIC
Explore the world of #oxylipins and their key roles in #inflammation. Our review highlights microbial oxylipins crucial to #infection—molecules that mimic host compounds. Evolutionary coincidence or microbial conspiracy?
mdpi.com/1467-3045/47/3/190 @MDPIOpenAccess @CIMB_MDPI @UKyMIMG
The future of academia thrives on building bridges, not walls. Despite uncertainty around funding, we must keep our focus on the bigger picture. True growth comes from uplifting others, not gatekeeping. The best academics aren't competitors -- they're collaborators. #TeamScience
Great #UNITY Breakfast this morning celebrating the life and legacy of Dr. Martin Luther King Jr. Thanks @Ablchapter1906 for organizing this wonderful event. ✊🏻✊🏼✊🏽✊🏾✊🏿#MLKDay #mlkday2025 @LexingtonKyGov
Christopher Radka retweeted
New Research: Dissecting the biophysical mechanisms of oleate hydratase association with membranes frontiersin.org/articles/10.…
🚨Paper in Press🚨 Our latest biophysical study of oleate hydratase binding the #membranebilayer is out!🔬#lipids #phosphorusNMR #spectroscopy #FluorescenceCorrelation #microscopy #singlemolecule #hybridtechniques @UKYMedicine @UKyMIMG @UK_COP
frontiersin.org/journals/mol…
Excited to share our latest work on oleate hydratase #evolutionarybiology, now in Press!📊 🖥 📰 #structuralbiology #phylogenetics #commonfold #sequencediversity @UKYMedicine
New Research: Independent evolution of oleate hydratase clades in Bacillales reflects molecular convergence frontiersin.org/articles/10.…
Great day for a #5K 👟! Happy to run with Team @UKyMIMG 🏃♀️🏃♂️ in the @UKYMedicine #MilesforMedicine 🛣🩺⚕️🏥. #microbiology #Community #Belonging 🤲❤️
Christopher Radka retweeted
Now online! Vaginal Lactobacillus fatty acid response mechanisms reveal a metabolite-targeted strategy for bacterial vaginosis treatment dlvr.it/TC6rHV
🚨NEW PAPER🚨
We use #cryoEM 🔬 to find the next structural level of oleate hydratase #OhyA: the OhyA•membrane complex! #OhyA, a peripheral enzyme, forms an oligomeric assembly on the #membrane #bilayer. @StJudeResearch @UKYMedicine @UKyMIMG @JStructBiol
sciencedirect.com/science/ar…
Thank you @ASBMB for the opportunity to serve as a panelist for: "#Academic #career, is it for me?"
I had a blast with fellow panelists Takita Sumter @winthropu, Pamela Mertz @StMarysMD, & Reinhart Reithmeier @UofT.
#ProfessionalDevelopment @UKYMedicine #sciencejobs #DiscoverBMB
My postdoctoral mentor unexpectedly passed away last fall, and I had an opportunity to write a retrospective piece on him. Check out the story of this #lipid #biochemistry pioneer. @ASBMB
@AsbmbLrd @StJudeResearch #worldexpert
Charles O. Rock (1949 – 2023) asbmb.org/asbmb-today/people…
🚨NEW PAPER🚨
We find PPARα is both target and attenuator of oleate hydratase #OhyA products. Our data indicate an OhyA-PPARα #signaling axis promotes #Staphylococcal #infection. #infectiousdiseases @UKYMedicine @StJudeResearch @FrontInfectDis @FrontiersIn frontiersin.org/articles/10.…