@ChowLab

Harnessing the power of natural variation --- Model organisms --- Disease modifiers --- ER stress --- Rare disease --- Dept. of Human Genetics / @UUtah

 Salt Lake City, UT
ChowLab.org
Joined March 2015
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  • Following538
  • Followers2.2K
64Media
Check out the amazing work of our drug screening team!
Clement Chow@ClementYChow28 Feb 2024
An incredible piece by @JulieCKiefer about our drug screening efforts for rare disease! Just in time for #RareDiseaseDay2024! #RareDiseaseDay uofuhealth.utah.edu/newsroom…

Rare But Not Forgotten

Finding treatments for children with rare diseases has been a significant hurdle in the medical world. An unexpected source, the common fruit fly, is turning up answers.

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Very excited to share our new paper on drug repurposing in a DPAGT1-CDG fly model: journals.plos.org/plosgeneti…. Thank you to everyone in the @ChowLab! More research in rare diseases and essential genes to come as a new Asst Prof in @KUMolBio.

A drug repurposing screen reveals dopamine signaling as a critical pathway underlying potential...

Author summary Some proteins require the attachment of sugars—like mannose and galactose—in order to perform their function. The process that attaches these sugars is called "glycosylation". Genetic...

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The @ChowLab is looking for postdocs! Lots of rare disease projects looking for genetic modifiers and drugs, all focused on translational potential. Opportunities to work in a basic science lab but interface with physicians, foundations, and families. static1.squarespace.com/stat…
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Check out new work from our lab!
Clement Chow@ClementYChow28 Oct 2024
NEW PAPER ALERT! @HansMDalton, former @chowlab postdoc, performed a drug repurposing screen in a fly model of DPAGT1 CDG, a disorder caused by mutations in the first step of N-linked glycosylation. 1/ journals.plos.org/plosgeneti…

A drug repurposing screen reveals dopamine signaling as a critical pathway underlying potential...

Author summary Some proteins require the attachment of sugars—like mannose and galactose—in order to perform their function. The process that attaches these sugars is called "glycosylation". Genetic...

journals.plos.org
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Hey #TAGC24! The @ChowLab is looking to hire everyone. Techs, postdocs, & research scientists! If you want to use or learn to use the fly to help people living with rare disease, find me! Read about how we’re using flies to find new rare disease medicines. uofuhealth.utah.edu/newsroom…

Rare But Not Forgotten

Finding treatments for children with rare diseases has been a significant hurdle in the medical world. An unexpected source, the common fruit fly, is turning up answers.

uofuhealth.utah.edu
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Great job, @HansMDalton!
Clement Chow@ClementYChow5 Jun 2023
Congrats to @ChowLab postdoc @HansMDalton on his successful K99 application! #funded
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Read about our newest partnership with @cureSYNGAP1!
Clement Chow@ClementYChow9 May 2023
A nice write up at @KSLcom about our partnership with @cureSYNGAP1 to try to find a possible therapy for SYNGAP1. Flies to the rescue. ksl.com/article/50638506/eye…

'Eye of the fly': How fruit flies could help find treatment for a rare genetic disease

A University of Utah researcher is using fruit flies — specifically studying their eyes — to screen drugs that could be used to treat patients with SynGAP-1, a rare genetic disease.

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“This is the time for rare diseases. In the next ten years, I think you’ll see therapies rolling out left and right because it’s just been waiting for the technology to be there. I think we have all the tools. What’s lacking is the funding.” – Clement Chow go.nature.com/3JOQ5Jv

Personalized medicine is having its day

Nature Biotechnology - From made-to-order genetic therapies to model organisms engineered to be ‘patient avatars’, the technology exists right now to save patients with rare diseases.

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It's so exciting that our science is having immediate real world impact in the lives of those living with rare diseases! So proud of the @ChowLab for working so hard at this.
Nature Biotechnology
@NatureBiotech20 Apr 2023
“This is the time for rare diseases. In the next ten years, I think you’ll see therapies rolling out left and right because it’s just been waiting for the technology to be there. I think we have all the tools. What’s lacking is the funding.” – Clement Chow go.nature.com/3JOQ5Jv

Personalized medicine is having its day

Nature Biotechnology - From made-to-order genetic therapies to model organisms engineered to be ‘patient avatars’, the technology exists right now to save patients with rare diseases.

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The @ChowLab has at least 2 postdoc positions open right now! DM or email if you’re interested! chowlab.org
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We’re looking a for a postdoc! Check out the ad below
Clement Chow@ClementYChow19 Dec 2022
The @ChowLab is looking for a postdoc to help evaluate potential drug therapies in #NGLY1 deficiency preclinical models. Lots of opportunities to interface with the NGLY1 community, physicians, and patients. #raredisease static1.squarespace.com/stat…
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If you’re a senior grad student and want to do a postdoc that could impact the lives of those living with rare disease, the @chowlab could be a good fit! Previous PDs who’ve worked on our projects get snapped up by industry bc of their rare disease and drug experience. DM me!
Clement Chow@ClementYChow2 Dec 2022
Fly drug screen results to testing an OTC drug in a kid living with a rare disease. Two weeks on the drug and the parents report meaningful changes.
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💥JOB ALERT💥 we are looking for a postdoc to help bring therapies to children living with rare disease. See below or DM me!
Clement Chow@ClementYChow31 Oct 2022
Are you interested in working at the interface of basic biology & translational science? The @ChowLab is looking for a postdoc to help develop precision medicine approaches for rare disease. If you are interested or know someone, please DM me!
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ALT view from the lab

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I'm excited to announce that the @ChowLab just formed a multi year partnership with the Center for Personalized Medicine at Primary Children’s Hospital and the Dept of Pediatrics to perform Drosophila-based, personalized repurposing drug screens for local rare disease patients.
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The @ChowLab is looking for a technician to help run our rare disease drug discovery pipeline. Duties include standard fly maintenance, setting up screens, phenotyping, & analyzing data. There will be opportunities to interact w/ physicians & patients utah.peopleadmin.com/posting…
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Congrats to @ChowLab student @mcalovesdna for getting a competitive spot on our Genetics T32 Training Grant!
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Watch out Duke, here comes our amazing technician @Shay_Scott25 to kick butt in grad school ❤️
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I am very thankful to @ClementYChow, our keynote @UIowaACB retreat, for showing up and singing the praises of my favorite model system, Drosophila melanogaster to discover and treat rare diseases 💛🪰💁🏼‍♀️ (And shout out to the @ChowLab for providing data for such a cool talk!)
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Grad students attending #Dros22, We are looking for postdocs to work on a number of different projects. You can get a flavor for some of them in this thread. Also, opportunities to work with physicians, patients and industry. DM if interested! And this view!
Clement Chow@ClementYChow5 Apr 2022
The @ChowLab is so excited to attend #Dros22! All 11 of us are attending in person! We have 5 posters and 2 talks! For many, it'll be the first meeting in person ever or since joining the lab. #excite
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So excited to be working on this! Our Rising Stars in Genetics and Genomics symposium will be awesome! It'll be 2 fun days of hearing about the science from these 12 up and coming leaders. Please register: docs.google.com/forms/d/1Ran…
U of Utah Human Genetics@UofUGenetics6 Apr 2022
We are excited to announce our first annual Rising Stars in Genetics and Genomics symposium (RiSinGG!) on May 11-12, 2022. We are excited to highlight the awesome science of these really talented postdocs. Please join us for two days of exciting science and food!
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