Excited to share our new paper, now online in OBC!
We report a propargyl uridine-based click chemistry strategy to access site-selectively glycosylated oligonucleotide analogues—useful glycoRNA mimics for structural and functional studies.
doi.org/10.1039/D6OB00597G @rsc_chembio
Can endogenous enzyme help control #CRISPR activity? In our new JOC article, we introduce nitroreductase-responsive oligomeric crRNAs for enzyme-triggered regulation of CRISPR activity, opening a strategy for hypoxia-associated settings. doi.org/10.1021/acs.joc.5c02… @ACSPublications
New in Advanced Materials: we built quinazoline-bridged COFs and show they enable selective photocatalytic sulfoxide synthesis from alkenes + thiols—highlighting how linkage chemistry tunes optoelectronics.
doi.org/10.1002/adma.2025236…
@advancematerial #COF #Photochemistry
Selective, site-specific RNA labeling—without the fuss. 🧬✨
In our new ChemBioChem article, we use tetrazine-based IEDDA to selectively modify allyl-functionalized RNA, with digestion confirming conjugation only at the allyl-modified site.
Read: chemistry-europe.onlinelibra…
Sequence-independent optical regulation of CRISPR/Cas editing using star-shaped crRNA dendrimers — a light-activated strategy enabling precise spatiotemporal control of CRISPR/Cas9 & Cas12a with minimal leakage. 🌟
doi.org/10.1039/D5CC06011G
@RoySocChem #CRISPR #GenomeEditing
🌱New Article in Adv. Agrochem.
“The capability of synthetic cytokinin mimics for in vitro regeneration of plants”
✨Synthetic cytokinin mimetics boost shoot & root growth
✨Potential tools for plant tissue culture & regeneration
📖 doi.org/10.1016/j.aac.2025.0…
🧬 New Review: Recent Advances in the Biological Functions of 5-Methyluridine (m⁵U) RNA Modification
👉 m⁵U: abundant, conserved, yet understudied
👉 Roles in tRNA stability, folding & translation
👉 Links to cancer, neurodegeneration & more
📖 Explore-> doi.org/10.6023/A25050152
Group 210 retweeted
Topology-Engineered Guide RNAs for Programmable Control of CRISPR/Cas Activity (Liang Cheng) #AngewandteReviews • onlinelibrary.wiley.com/doi/…
🌱 Excited to share our article "Harnessing Cytokinins with Chemistry" is provisionally accepted in Front. Plant Sci.!
We highlight chemical tools enabling precise control of plant hormones—paving the way for smarter, sustainable crop growth. 🌾🧪
doi.org/10.3389/fpls.2025.16…
🔥 Excited our paper is now a Hot Paper in @angew_chem ! @Wiley_Chemistry
Star-shaped crRNAs enable precise photo-controlled CRISPR/Cas editing in cells & in vivo. 🌟📸
👉 doi.org/10.1002/anie.2025065…
#CRISPR #GeneEditing #Photocontrol #AngewChem
RNA epigenetics meets chemical biology! Our review just published in Acc. Chem. Res. highlights purely chemical strategies to precisely control RNA modifications, impacting gene regulation and cellular function. Read 👉doi.org/10.1021/acs.accounts… @ACSPublications #RNA #Epigenetics
🚨New in ACS Synthetic Biology!
Our recent work in Light-activated CRISPR/Cas12a detection:
🔒Inactive crRNA during amplification
☀️Light activation enables precise detection
⚡Simple, rapid, versatile for diagnostics
pubs.acs.org/doi/10.1021/acs…
#CRISPR #SyntheticBiology #Diagnostics
Excited to share that our collaborative article with Prof. Mark Helm, "A Direct Chemical Repair of Etheno-Type RNA Damages," has been published in Angewandte Chemie! 🎉 Cheers to the team! @AttheHelm3 @angew_chem @Wiley_Chemistry onlinelibrary.wiley.com/doi/…
Our recent work "A Live-Cell Epigenome Manipulation by Photo-Stimuli-Responsive Histone Methyltransferase Inhibitor" has been published on @AdvSciNews @Wiley_Chemistry onlinelibrary.wiley.com/doi/…
Our invited review "Advances in the Investigation of N6-Isopentenyl Adenosine i6A RNA Modification" has been published online at Bioorganic & Medicinal Chemistry in honor of Professor Chuan He @ELSchemistry @TetrahedronChem doi.org/10.1016/j.bmc.2024.1…
Our invited review "More than just Alkene Construction – Re-using Wittig Reactions/Reagents in Biomacromolecular Labeling, Imaging, Sequencing and Modification" at @AnalysisSensing @Wiley_Chemistry doi.org/10.1002/anse.2023000…
More than just Alkene Construction - Re-using Wittig Reactions/Reagents in Biomacromolecular Labeling, Imaging, Sequencing and Modification (Liang Cheng and co-workers) onlinelibrary.wiley.com/doi/…
Our most recent work "Discovery of Photoexcited 2-Chloro-3,5-Dinitrobenzoic Acid as a Chemical Deprenylase of i6A RNA" at @ChemBioChem as an VIP article!!! @Wiley_Chemistry doi.org/10.1002/cbic.2024003…
Our work "Total synthesis of all stereoisomers of C5-glyceryl-methyl-2'-deoxycytidine 5gmC and their occurrence in green alga Chlamydomonas reinhardtii" has finally been online @CellRepPhysSci #50YearsofCell doi.org/10.1016/j.xcrp.2024.…
Our work "A direct synthesis of 5-azidomethyl pyrimidine nucleosides via dehydroxyazidation" on Tetrahedron Letters @ELSchemistry #TetrahedronLetters doi.org/10.1016/j.tetlet.202…
Our most recent article "Chemical control of CRISPR/Cpf1 editing via orthogonal activation and deactivation of crosslinked crRNA" has just published in @ChemCommun as part of the themed collection: 2024 Pioneering Investigators @RoySocChem #ChemComm60 doi.org/10.1039/D4CC01106F