@ChenLabWustl

Lots of Chen labs at @WUSTLmed, but only one Dave Chen lab! Studying skin aging, premalignancy, cancer, and epigenetics @WashUDerm

 Washington University
sites.wustl.edu/chenlab/
Joined March 2021
  • Tweets103
  • Following192
  • Followers201
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Dave Chen Lab retweeted
Aaron Newman Lab@AaronNewmanLabJul 5
An honor to discuss our recent @Nature paper with @EricTopol on his Ground Truths podcast! See his fantastic thread below and a link to our conversation here: erictopol.substack.com/p/a-b…
Eric Topol
@EricTopolJul 5
For treatment and outcomes for cancer, the tumor microenvironment (TME) is pivotal, but we've never had a non-invasive way to assess it. Until now, a blood test breakthrough! (<-a term I use sparingly) Pictured below, schematically, the TME surrounds the cancer cells and consists of immune cells, blood vessel (endothelial) cells, fibroblasts and matrix
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What a day it has been!!! @AaronNewmanLab and I started this journey years ago back when we were both junior faculty. A difficult question — Can we perform liquid biopsy of the tumor microenvironment? Spoiler alert. We finally did it! In @Nature & on @CNN today w/ @jaketapper!!
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Dave Chen Lab retweeted
Aaron Newman Lab@AaronNewmanLabMay 6
1/ Thrilled to share our new paper, out today in @Nature: "Non-invasive profiling of the tumour microenvironment with spatial ecotypes". Paper (open access): nature.com/articles/s41586-0…

Non-invasive profiling of the tumour microenvironment with spatial ecotypes

Nature - Multimodal machine learning reveals that tumour microenvironments can be decomposed into spatially organized multicellular ecosystems, termed spatial ecotypes, that can be accessed...

nature.com
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Love this collaboration!
Saligrama lab_WUSTL@SaligramaLabMar 15
Here it is Combined talimogene laherparepvec and binimetinib in patients with NRAS-mutated melanoma induces anti-tumor immunity medrxiv.org/content/10.64898…

Combined talimogene laherparepvec and binimetinib in patients with NRAS-mutated melanoma induces...

Immune checkpoint blockade can produce long-lasting responses in patients with metastatic melanoma; notably, combined CTLA-4/PD-1 blockade has been associated with approximately 52% melanoma specific...

medrxiv.org
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Check out our multi-institutional outcomes for advanced melanoma patients treated with intratumoral talimogene laherparepvec. Kudos to our partners at UW Derm Song Park and colleagues for their great work!
Journal for ImmunoTherapy of Cancer
@jitcancerJan 7
New #JITC article: Real-world outcomes of talimogene laherparepvec as salvage therapy for advanced melanoma jitc.bmj.com/content/13/12/e… @PaulNghiem
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New #JITC article: Real-world outcomes of talimogene laherparepvec as salvage therapy for advanced melanoma jitc.bmj.com/content/13/12/e… @PaulNghiem
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Read our latest #research on #extramedullaryAML published with @SpringerNature in @BloodCancerJnl Thanks to the @LeukemiaRF for funding this work! ⬇️⬇️⬇️ rdcu.be/eADE4
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Dave Chen Lab retweeted
NEJM
@NEJM25 Mar 2025
Our partnership with @DGlaucomflecken continues as he summarizes the final, 10-year outcomes of the CheckMate 067 trial, which investigated nivolumab plus ipilimumab in advanced melanoma. Access the article for free: nej.md/42V5Pps
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Congratulations, Elijah! Seniors Darden, Seiler were Rhodes Scholars finalists source.washu.edu/2024/11/sen…
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Team @WashUMedDerm had a great time at the #MontagnaSymposium! Great talks by @leoshmu and @aayushi_uberoi, poster prizes to students Favour and Maysoon, travel awards to @damienabreu, @aayushi_uberoi, and Favour. Already looking forward to next year!
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What did we #learn after #sequencing #5million #Tcells #scRNA and #TCRseq with @lisa_wagar @andimscience @suhaschandra87 and funding agency @WellcomeLeap @STLChildrens -Tissue determinants of the human T cell receptor repertoire. biorxiv.org/content/10.1101/…

Tissue determinants of the human T cell receptor repertoire

98% of T cells reside in tissues, yet nearly all human T cell analyses are performed from peripheral blood. We single-cell sequenced 5.7 million T cells from ten donors’ autologous blood and tonsils...

biorxiv.org
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Congratulations to @LesSutton_ for escaping the lab! Best wishes in graduate school!
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Excited and grateful to be a part of this amazing team!
Aadel Chaudhuri, MD PhD@aadel_chaudhuri10 Jun 2024
This R01 NoA from @theNCI wouldn’t have been possible without strong Multi-PI collaboration with @AaronNewmanLab @StanfordCancer —Equal joint effort between us MPIs + Co-Is @ChenLabWustl @WashUDerm & Ruth Halaban / @MSznol @YaleMed Looking forward to the #TeamScience ahead!
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Nice talk and cool phenotype in your CEP43 KO @christinecy #SID2024Dallas
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Another year, another @WashUDerm @WUSTLmed reunion at the #SID2024Dallas, bringing together @WashUDPS Derm-scientists with compatriots abroad
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Great work Melissa and Smitha! They spent countless hours putting together data for the #SID2024Dallas meeting. Kudos!
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Song Park @DermatologyUW highlighted our collaborative work @WashUDerm on T-VEC at the plenary session for #SID2024Dallas. Proud to have great collaborators!
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A great kickoff to #SID2024Dallas from our Chief of Dermatology @WashUDerm and SID president Dr. Lynn Cornelius
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Congratulations @NoraAlex77 !! Best wishes on your next chapter--can't wait to see your future successes @DermatologyUW !
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Celebrating Marissa's amazing work establishing our skin cancer biobank @WashUDerm and wishing her the best in her next chapter!
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