This account is run by members of the Chaput Lab 🥼 Pioneering the next generation of diagnostic and therapeutic agents 🧬
Irvine, CA
Joined May 2021
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Happy graduate commencement and congratulations to our new Drs. Erica Lee, Victoria Maola-Gross, and Mohammad Hajjar! It’s so easy to celebrate such amazing students! 🎊🙌
Happy belated birthday to our wonderful PI, Dr. Chaput, who the lab celebrated early this week! Cheers to another great year ahead 🥂
We love our undergrads! Our very own Pranav Das (‘26) presented his crystallography research through UCI’s Undergraduate Excellence in Research program yesterday. Keep up the great work! ✨🧬
Congratulations to our incredible Joy Lee on her successful advancement Tuesday! We’re so excited to keep watching you shine 💪🏻✨
Pop the champagne! 🍾 Our very own Victoria successfully defended her thesis on the evolution and structural elucidation of TNA polymerases this week! Congrats, Dr. Maola-Gross—we couldn’t be prouder!! 🎉
The @ChaputLab holds great opportunities for undergraduates at UCI to pursue research in structural biology. Check out this article highlighting one of our star students, Gracie Ko!
pharmsci.uci.edu/2026/02/17/…
Our matching XNA scientists were spotted presenting their research today during the PharmSci PhD prospective student week! ☀️
Newly published in NAR: the @ChaputLab has demonstrated TNA’s utility in gene silencing by enhancing the cellular activity and stability of RNA-targeting DNAzymes. A big step forward towards the future of oligonucleotide therapeutics! ✨🔬 academic.oup.com/nar/article…
How does evolution reshape enzyme activity? In a recent Nature Communications paper, members of the @ChaputLab are helping answer this question through new insight on the forces responsible for shaping enzyme function. Check it out! nature.com/articles/s41467-0…
Our incredible Erica Lee was named one of UCI’s annual Pharmaron Fellows! Congrats to Erica on her hard work and success throughout graduate school!
Major kudos to members of the @ChaputLab for their recent publication in Nature Chemical Biology, pushing the boundaries of enzyme evolution with a robust and highly processive RNA polymerase! Looking forward to more exciting campaigns in 2026 🎊🧬
Inspired by nature, chemists have spent the last 50 years systematically designing and synthesizing a vast array of sugar modified nucleic acids, so-called xenonucleic acids (XNAs). Check out this NAR review on the XNA alphabet! academic.oup.com/nar/article…
Big congratulations to Clark, who recently defended his Masters thesis, titled: “Development of Improved Scalable Synthesis of Nucleoside Triphosphates.”
Well done, Clark! 🎓⭐️
Congrats to our PhD student @MaolaVictoria, recipient of UCI pharmaceutical science’s Henry Wood Elliot Award! 👏
Chaput Lab retweeted
Big congrats to Dr. John Chaput, ranked #24 in the world in Synthetic Biology by @ScholarGPS! This Top Scholar honor puts him in the top 0.5% of researchers worldwide based on impact, citations & productivity. @ChaputLab
John Chaput and Mano Manoharan at the Nucleic Acid Therapies meeting, hosted at Cold Spring Harbor Laboratory! @CSHL
Chaput Lab retweeted
Our PhD students showcased their groundbreaking research at our PhD Campus Visit Poster Session! 📊✨ Prospective students had the opportunity to connect with current PhD candidates and faculty members, gaining insights into our PhD in Pharmacological Sciences program at UCI.
Congrats to Esau Medina for his work on measuring XNA polymerase fidelity in hydrogels -- just accepted into NAR! Starting 2025 off strong!