@CenikLab
 Austin, TX
ceniklab.github.io/
Joined October 2019
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Ribo-ITP enables ribosome occupancy measurements from single cells. Our first application revealed insights into allele-specific ribosome engagement in early development (nature.com/articles/s41586-0…). #RiboITP #singlecell

Single-cell quantification of ribosome occupancy in early mouse development

Nature - A single-cell ribosome profiling method can provide data at the level of allele-specific ribosome engagement in early development.

nature.com
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Replying to @arjunrajlab
Earlier this summer I came across this and recommended to a new student in the lab: courses.ibiology.org/catalog…

Planning Your Scientific Journey

Plan your science career with our FREE course on strategic planning, crafting research questions, and mentorship for students and postdocs.

sciencecommunicationlab.org
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In our new preprint, we integrated three multiplexed assays of variant effect to profile several layers of gene expression for thousands of variants in COMT! biorxiv.org/content/10.1101/…

Integrated multiplexed assays of variant effect reveal cis-regulatory determinants of catechol-O-...

Multiplexed assays of variant effect are powerful methods to profile the consequences of rare variants on gene expression and organismal fitness. Yet, few studies have integrated several multiplexed...

biorxiv.org
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Through collaborations, we're applying Ribo-ITP to diverse areas like early mouse limb development, brain organoids, immune cells, and rare cancer cells. If you are interested in adopting Ribo-ITP, here is our step-by-step protocol with video instructions: ceniklab.github.io/ribo_itp/

Ribo ITP Protocol

Translation Control and Computational Biology

ceniklab.github.io
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Intrigued by the potential of Ribo-ITP in uncovering the intricacies of cellular translation? We're seeking motivated postdocs to join our team, we'd love to connect with you!
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We are happy to unveil our latest published work where we describe how the metabolic enzyme, Pyruvate Kinase (PKM), regulates global mRNA translation in human cells. Here's a short 🧵... academic.oup.com/nar/advance…

Pyruvate Kinase M (PKM) binds ribosomes in a poly-ADP ribosylation dependent manner to induce...

Abstract. In light of the numerous studies identifying post-transcriptional regulators on the surface of the endoplasmic reticulum (ER), we asked whether t

academic.oup.com
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Cenik Lab retweeted
Vokes_Lab@LabVokes
18 Nov 2022
Our study showing that Hedgehog signaling is essential for maintaining the early foregut and larynx by preventing EMT was published: doi.org/10.7554/eLife.77055 @eLife. This was led by recent @UTexasILS graduate Janani Ramachandran with help from Hongkai Ji @jihk99 and @ZornLab.

Hedgehog regulation of epithelial cell state and morphogenesis in the larynx

HH signaling prevents precocious EMT and cell death to maintain epithelial cell states during early stages of larynx development.

elifesciences.org
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Congratulations to the 2022 @UT_iGEM team for winning the the Best Foundational Advance award at the iGEM Grand Jamboree! They were also a top 10 overall undergraduate team, finalists for Best Presentation and Best Part Collection, and awarded a Gold Medal. @ut_mbs @TexasScience
iGEM@iGEM
28 Oct 2022
Replying to @iGEM
Congrats to the teams from Freiburg and Austin!
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Our 1st effort into dissecting the crosstalk between #autophagy & other vacuolar trafficking pathways, now out in @JCellBiol Thx to everyone involved!
GMI Vienna gmivienna.bsky.social@gmivienna
19 Oct 2022
‼️ #JustPublished in @JCellBiol New work from the Dagdas Lab at GMI @PlantoPhagy sheds light on the mechanism of #autophagosome maturation in #plants 🌱🌿 Read more: ➡️ bit.ly/PlantAmphisome #autophagy #plantautophagy #plantorganelle #organelletrafficking #amphisome 1/3
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Hypodermal ribosome synthesis inhibition induces a nutrition-uncoupled organism-wide growth quiescence in C. elegans biorxiv.org/content/10.1101/… @SarinayElif

Hypodermal ribosome synthesis inhibition induces a nutrition-uncoupled organism-wide growth...

Inter-organ communication is a key aspect of multicellular organismal growth, development, and homeostasis. Importantly, cell-non-autonomous inhibitory cues that limit tissue specific growth altera...

biorxiv.org
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🌮BioTACOS tomorrow, Mon Oct 17, 2022 9:30 am- 🌮 "RiboBase: A comprehensive databse of ribosome profiling data" by Hakan Ozadam in @CenikLab Please join in!
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It was great hearing all the wonderful science. Thanks so much for the visit!
Guramrit Singh@1guramritsingh
15 Sep 2022
In person seminar visits are so so much better! Thank you @CenikLab for hosting me @UTAustin. Learned a lot and specially enjoyed talking to the trainees!
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It was our pleasure to host @SarinayElif for a virtual seminar today. Thanks a lot Elif for showing us the wonders of C.elegans and sharing your most recent findings with us.
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The MEF boss himself, @LabVokes , demonstrates the secrets and arts of MEF derivation!
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AGBT Abstract: @CenikLab from @UTAustin discusses single cell quantification of ribosome occupancy in early mouse development at the 2022 @AGBT General Meeting in Orlando. #AGBT22
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We had a great time at #RNA2022. Lots of exciting talks including from @SarinayElif and @Jamie_Yelland. Looking forward to watching the recorded talks that we missed during the meeting.
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Our latest work on HIV-1 translation: Extensive uORF translation from HIV-1 transcripts conditions DDX3 dependency for expression of main ORFs and elicits specific T cell immune responses in infected individuals biorxiv.org/content/10.1101/…

Extensive uORF translation from HIV-1 transcripts conditions DDX3 dependency for expression of main...

Human immunodeficiency virus type-1 (HIV-1) is a complex retrovirus which relies on alternative splicing, translational and post-translational mechanisms to produce more than 15 functional proteins...

biorxiv.org
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Cell autonomous and non-autonomous consequences of deviations in translation machinery on organism growth and the connecting signalling pathways dlvr.it/SPK6Cl
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