@Cell_Tokyo_Tech

Journey of a Cell Biologist

Joined September 2018
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  • Following14
  • Followers253
3Media
Work on knock-in mice expressing a histone modification probe (mintbody) was published. Mouse lines were generated by Jun Ueda and Kazuo Yamagata (> 10 yrs ago) and the analysis were done by Yuko Sato, Maoko Takenoshita, and Miku Ueoka. Congratulations! doi.org/10.1007/s00418-024-0…

Visualizing histone H4K20me1 in knock-in mice expressing the mCherry-tagged modification-specific...

Histochemistry and Cell Biology - During development and differentiation, histone modifications dynamically change locally and globally, associated with transcriptional regulation, DNA replication...

link.springer.com
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A preprint reporting knock-in mice expressing histone H4K20me1-mintbody, by Yuko Sato and former students, in collaboration with Jun Ueda and Kazuo Yamagata. doi.org/10.1101/2024.03.13.5…
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Congratulations Martino and Nadine!
Nadine Vastenhouw@NVastenhouw8 Apr 2024
It’s finally out! The PhD work and first first author paper of @MartinoUgolini: rdcu.be/dD5Vd. Congrats to all co-authors @mkierun, @lanoliin, Hiroshi Kimura, and Haruka Oda for the beautiful work! We also thank @cSabrya @NatureCellBio for the pleasant review process.
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Work by Naoki Goto (@Naoki_Goto_), a PhD student, about histone H3K36me2 on heterochromatin was just published, in collaboration with labs of K. Yamagata, H. Kurumizaka, and H. Nishihara. Congratulations! doi.org/10.1083/jcb.20231008…

ISWI chromatin remodeling complexes recruit NSD2 and H3K36me2 in pericentromeric heterochromatin

The authors discovered histone H3K36me2, which is believed to be enriched in potentially active genomic regions, is also located in transcriptionally inact

rupress.org
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Work by Masaru Nakao, who is getting PhD, was just published. Mode of SUV420H2 heterochromatin localization through multiple HP1 binding motifs in the heterochromatic targeting module - Nakao - Genes to Cells - Wiley Online Library onlinelibrary.wiley.com/doi/…

Mode of SUV420H2 heterochromatin localization through multiple HP1 binding motifs in the heteroch...

SUV420H2 heterochromatic targeting module (HTM) contains three HP1 binding motifs and their cooperative binding to HP1 stabilizes, or locks, HP1 on heterochromatin. An HTM mutant that does not...

onlinelibrary.wiley.com
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A review with Hiroshi Ochiai and colleagues came out. Organization of transcription and 3D genome as revealed by live-cell i... sciencedirect.com/science/ar…
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Our #MidweekMovie shows actin dynamics in a #zebrafish embryo from Haruka Oda, @Cell_Tokyo_Tech, et al. They find that f-actin accumulates in the nucleus of early embryos & forms patches associating with condensing chromosomes. 📖@BiologyOpen: journals.biologists.com/bio/…
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Haruka Oda at the First person interview. doi.org/10.1242/bio.059972

First person – Haruka Oda

ABSTRACT. First Person is a series of interviews with the first authors of a selection of papers published in Biology Open, helping researchers promote themselves alongside their papers. Haruka Oda...

journals.biologists.com
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Nuclear F-actin dynamics in the early embryo, in collaboration with Nadine Vastenhouw, Shige Kawashima, Motomu Kanai, and colleagues. Congratulations Haruka! journals.biologists.com/bio/…

Actin filaments accumulated in the nucleus remain in the vicinity of condensing chromosomes in the...

Summary: Filamentous actin accumulates in the nucleus of zebrafish early embryos and forms patches associating with condensing chromosomes during prophase.

journals.biologists.com
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Collaborative work led by Yoichi Shinkai revealed what happens to chromatin organization when mouse cells lack both H3K9 and H3K27 methylation marks. Congratulations Kei! doi.org/10.1093/nar/gkad387

Epigenetic plasticity safeguards heterochromatin configuration in mammals

Abstract. Heterochromatin is a key architectural feature of eukaryotic chromosomes critical for cell type-specific gene expression and genome stability. In

academic.oup.com
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The formatted version of γ-H2AX dynamics paper by Fern (Watanya) is now available. journals.biologists.com/jcs/…
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Ph.D. work by Fern (Watanya) is now published. Congrats! Watanya Trakarnphornsombat, Hiroshi Kimura; Live-Cell Tracking of γ-H2AX Kinetics Reveals the Distinct Modes of ATM and DNA-PK in Immediate Response to DNA Damage. J Cell Sci 2023; jcs.260698. doi: doi.org/10.1242/jcs.260698

Live-cell tracking of γ-H2AX kinetics reveals the distinct modes of ATM and DNA-PK in the immediate...

Summary: Live-cell imaging reveals that DNA-dependent protein kinase, but not ATM, plays a primary role in the phosphorylation of histone H2AX during the immediate early response to DNA damages.

journals.biologists.com
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STREAMING-tag paper (with RNA polymerase II Ser5ph-specific mintbody) came out. Congratulations Hiroaki, Hiroshi O, and all collaborators! nature.com/articles/s41467-0…

STREAMING-tag system reveals spatiotemporal relationships between transcriptional regulatory...

Nature Communications - Using the newly developed STREAMING-tag system, the authors find that clusters of RNA polymerase II and BRD4 are formed specifically in the transcriptionally active state...

nature.com
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Work by Misako Tanaka, a visiting Ph.D. candidate from Tokyo Medical and Dental University, was published. Congratulations! The role of H3K9me3 in oral squamous cell carcinoma sciencedirect.com/science/ar…
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Satoshi Uchino's paper was selected for one of the Year in Cell Biology 2022 articles. Congratulations!
Journal of Cell Biology@JCellBiol2 Dec 2022
Satoshi Uchino et al. develop a new probe for phosphorylated #RNA polymerase II which enables visualization of the sites of #transcription in living cells. bit.ly/3ryUMj8 From the Year in Cell Biology 2022: bit.ly/3UxePJT #CellBio2022
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Congratulations Nadine, Ksenia, and colleagues!
Nadine Vastenhouw@NVastenhouw6 Dec 2022
Our story about the spark of life now in published form cell.com/current-biology/ful…, so it's time for a shout-out to @currentbiology, @AnneKnowlton1, and our anonymous reviewers for the efficient, pleasant, and constructive review process. Thank you!
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Work by Haruka Oda on nuclear filamentous actin in zebrafish early embryos, in collaboration with groups of Nadine Vastenhouw (Lausanne) and Shigehiro Kawashima and Motomu Kanai (Tokyo). biorxiv.org/content/10.1101/…

Actin filaments accumulate in the nucleus during interphase and remain in the vicinity of condens...

In the cytoplasm, filamentous actin (F-actin) plays a critical role in cell regulation, including cell migration, stress fiber formation, and cytokinesis. Recent studies have shown that actin...

biorxiv.org
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Work of a Ph.D. student, Fern (Watanya Trakarnphornsombat). She monitored γ-H2AX accumulation at DNA damage sites in living cells and found different regulations by ATM and DNA-PK. biorxiv.org/content/10.1101/…

Live-Cell Tracking of γ-H2AX Kinetics Reveals the Distinct Modes of ATM and DNA-PK in Immediate...

DNA double-strand break (DSB) is a serious form of DNA damage that can cause genetic mutation. On the induction of DSBs, histone H2AX becomes phosphorylated by kinases, including ataxia telangiecta...

biorxiv.org
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In-person EMBO Laboratory Leadership Course (12/3; Tokyo) and International Symposium for Female Researchers in Chromatin Symposium (12/5; online).
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Congratulations Yohei, Takeshi, and colleagues!
Y Kono@Yo_Hey_Kono27 Oct 2022
Excited to share that our latest paper is finally out in @JCellBiol. Much data has been added since the bioRxiv version released in January.
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