@CastleLabBYU

Organic synthesis. Radical chemistry. Peptide chemistry. At BYU since 2002.

 Provo, UT
chem.byu.edu/faculty/steven-l-castle/
Joined August 2018
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  • Following312
  • Followers550
30Media
We are excited to announce that Dr. Stephanie Garcia-Morin has successfully defended her dissertation and was granted her PhD in Chemistry last Friday! She will begin teaching at Utah Valley University this fall. Congrats Dr. Garcia-Morin!
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We are pleased to announce our recent publication in the ACS Journal of Organic Chemistry demonstrating our work with dehydroamino acids. Give it a read here! pubs.acs.org/doi/pdf/10.1021…
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This week we celebrated four talented students graduating from our group during this academic year! - Stephanie Garcia-Morin (PhD, August 2026) - Brad Cloward (Molecular Biology, April 2026) - Laura McPhie (Chemistry, April 2026) - Christian Evans (Biochemistry, April 2026)
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The Organic Chemistry Portal has highlighted our recent publication "Microwave-Promoted Synthesis of 1-Tetralones via Iminyl Radical-Mediated 1,5-Hydrogen Atom Transfer" (DOI: 10.1021/acs.joc.4c02887). Check out this webpage: organic-chemistry.org/abstra…
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Grillin' and chillin' at the annual cook out! This year we have many new group members. Welcome! Thank you all, members and family. It was a blast!
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We are very excited to share our most recent publication! Microwave-Promoted Synthesis of 1-Tetralones via Iminyl Radical-Mediated 1,5-Hydrogen Atom Transfer | The Journal of Organic Chemistry pubs.acs.org/doi/10.1021/acs…

Microwave-Promoted Synthesis of 1‑Tetralones via Iminyl Radical-Mediated 1,5-Hydrogen Atom Transfer

Abstract. Microwave irradiation of O-phenyloximes produces 1-tetralones via N–O homolysis, 1,5-hydrogen atom transfer (HAT), and cyclization of a radical i

pubs.acs.org
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Before the year ends, we would like to THANK our former Castle Lab members for their contributions, work and motivation. Good luck in your new projects! 2024 has been a year of learning and we also want to share some of these victories and great moments. Merry Christmas Friends!
Congratulations to Spencer Jones for his graduation this semester 🥳, for 3 years of hard work and dedication in this lab.

ALT Congratulations to Spencer Jones for his graduation this semester 🥳, for 3 years of hard work and dedication in this lab.

A round of applause for Jude Osayawe for having his doctoral proposal approved!

ALT A round of applause for Jude Osayawe for having his doctoral proposal approved!

Welcome to our first year Grad students: Caleb Petersen (picture) and Ethan Downeng. Very excited to work together!

ALT Welcome to our first year Grad students: Caleb Petersen (picture) and Ethan Downeng. Very excited to work together!

Congratulations to Logan Knox, Jared Xia, Elias Griffin, Nathan Engel, and Joseph Watts on their graduation earlier this year. We welcome members who joined this year: Stephen Crawford, Josh Payne, Trevor Murray, and Bradley Coward. Thank you to our members and their families for their support!

ALT Congratulations to Logan Knox, Jared Xia, Elias Griffin, Nathan Engel, and Joseph Watts on their graduation earlier this year. We welcome members who joined this year: Stephen Crawford, Josh Payne, Trevor Murray, and Bradley Coward. Thank you to our members and their families for their support!

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Here are some photos from Steve's recent trip to India. Many thanks to Castle group alumnus Prof. Biplab Banerjee of Central University Punjab for being such an excellent host!
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It is not too late to post our "Grillin' and chillin' 2024." On June 22nd, we held our annual cookout as a lab group. We had a great time with friends and family! WELCOME to the new members of the lab group and a big THANK YOU to those who are leaving us. Success!
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Thrilled to announce Professor Ben List @ListLaboratory as the Plenary Speaker at WIPOS 2024 (December 16-19, 2024 in Honolulu, Hawaii; wipos.org)! Check out the short video that shows all of our invited speakers. Registration is now open: signup.rice.edu/WIPOS2024
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Here are some photos from Steve's recent trip to China. Many thanks to Castle group alumnus Yu Cai for arranging the trip and being such a great host.
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We are very excited to share our most recent publication! Synthesis of the Indolizidine Core of Virosinine A via a Microwave-Promoted Cascade Cyclization Involving Iminyl Radicals | Organic Letters pubs.acs.org/doi/10.1021/acs…

Synthesis of the Indolizidine Core of Virosinine A via a Microwave-Promoted Cascade Cyclization...

Abstract. The indolizidine core of virosinine A was synthesized by means of a microwave-promoted cascade reaction featuring 5-exo-trig iminyl radical cycli

pubs.acs.org
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We would like to thank Dr. Alexander Ramos and Dr. Jatinder Singh for their hard and valuable work at The Castle Lab throughout this time. Success in your current and upcoming projects!
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Castle Group retweeted
Laszlo Kurti@kurtilaszlo8 Aug 2023
Thrilled to announce Prof. Scott J. Miller @MillerGroupYale as the Plenary Speaker at WIPOS 2023 (wipos.org, December 18-21, 2023) in Honolulu, HI. Register at signup.rice.edu/WIPOS2023/ to hear 42 speakers, present posters, network with organic chemists and have fun!
There will be 42 speakers and also a continuous poster session associated with this symposium. One day will be dedicated to lectures from 12 young investigators (i.e. ≤10 years from starting their independent careers, including 11 pre-tenure faculty members). The remaining 3 days will feature a combined 30 speakers from both academia and industry. WIPOS 2023 will be held at the Hilton Hawaiian Village Waikiki Beach Resort in Honolulu, Hawaii. The symposium attendance will be limited to a total of 150 participants.

ALT There will be 42 speakers and also a continuous poster session associated with this symposium. One day will be dedicated to lectures from 12 young investigators (i.e. ≤10 years from starting their independent careers, including 11 pre-tenure faculty members). The remaining 3 days will feature a combined 30 speakers from both academia and industry. WIPOS 2023 will be held at the Hilton Hawaiian Village Waikiki Beach Resort in Honolulu, Hawaii. The symposium attendance will be limited to a total of 150 participants.

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Check out our latest publication: doi.org/10.1021/acs.joc.3c00… Congrats Jatinder Singh and #RadicalTeam!

Formal γ‑C(sp3)–H Activation of Ketones via Microwave-Promoted and Iminyl-Radical-Mediated 1,5-Hy...

Abstract. Microwave irradiation of O-phenyloximes triggers N–O homolysis and 1,5-hydrogen atom transfer (HAT), resulting in formal γ-C–H functionalization

pubs.acs.org
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"Grillin' and chillin'." This Saturday we had our annual cookout as a lab group. It was so funny! We played, we ate and we are ready for whatever comes.
Cookout 2023

ALT Cookout 2023

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It has been a pleasure working with all of you. Thank you for your contribution to this group. We are proud of your achievements! 🎓Congratulations!!!!🎓
From left to right: Samuel Mansfield (B.S Chemistry), Felix Ho (B.S. Biochemistry), Jatinder Singh (PhD Chemistry), Dr Steven Castle (Advisor), Julie Valentina Jimenez (B.S. Biochemistry) and Alexander Ramos (PhD Chemistry)

ALT From left to right: Samuel Mansfield (B.S Chemistry), Felix Ho (B.S. Biochemistry), Jatinder Singh (PhD Chemistry), Dr Steven Castle (Advisor), Julie Valentina Jimenez (B.S. Biochemistry) and Alexander Ramos (PhD Chemistry)

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Excited to see this paper published today. Congrats Jatinder Singh and #RadicalTeam! Microwave- and Thermally Promoted Iminyl Radical Cyclizations: A Versatile Method for the Synthesis of Functionalized Pyrrolines pubs.acs.org/doi/10.1021/acs…

Microwave- and Thermally Promoted Iminyl Radical Cyclizations: A Versatile Method for the Synthesis...

Abstract. A detailed study of iminyl radical cyclizations of O-aryloximes tethered to alkenes is reported. The reactions can be triggered by either microwa

pubs.acs.org
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Castle Group retweeted
Craig Hutton@Hutton_Lab28 Sep 2022
This one brings an exhausted, contented smile. A true pandemic paper, delayed by lab shutdowns, international travel bans, and 'procrastination' in writing due to being head of teaching throughout the pandemic. But it's finally done! Congrats to Ameer and thanks to all.
Angewandte Chemie@angew_chem22 Sep 2022
Site Specific Preparation of N-Glycosylated Peptides: Thioamide-Directed Activation of Aspartate (Hutton) @Hutton_Lab @Bio21Institute #OpenAccess onlinelibrary.wiley.com/doi/…
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Lunch to say goodbye to Tanner and Jaden. It has been a great experience having them at the @CastleLabBYU . Thank you for your contributions, work and enthusiasm. Success in your new projects!
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