
Passionately studying how environmental stressors harm the heart. Environmental cardiologist. š„ š« š§ š« @UofLenvirome
Louisville, KY
Joined November 2017
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New from our lab: repeated e-cigarette exposure transiently evokes arrhythmias via the beta1 adrenoceptor, consistently increases BP, changes the cardiac proteome, and persistently depresses HR and ventricular repolarization. ahajournals.org/doi/full/10.⦠@CIEHS_UofL @CardioMetaboSci
CardioCarll retweeted
Iran has no nuclear weapons and canāt ātake outā L.A. or San Diego. But a U.S. President nevertheless inviting it to do so puts us in 25th Amendment territory. Trump is unfit and must go.
CardioCarll retweeted
Your brain produces somewhere around 60,000 to 80,000 thoughts a day. According to a figure widely cited from the National Science Foundation, up to 80 percent of them are negative, and up to 95 percent are the same ones you had yesterday.
That means the voice in your head is running on a loop, and the loop is biased toward threat, because the brain evolved to keep you alive, not to keep you happy. A thought like "I am not ready for this" fires the amygdala, your brain's alarm centre, which floods you with cortisol, the stress hormone. Cortisol makes you more reactive and more likely to have the same thought again, and the repetition digs the groove deeper each time.
This is why affirmations work as counter-programming. When you repeat a sentence like "I can handle this," you are building a competing pathway. The first few times it feels empty, because the old groove is deeper. But the brain rewires itself based on what it practises, and a 2015 study from the University of Pennsylvania found that a repeated values affirmation activates the prefrontal cortex, the part of the brain that handles reasoning, and quiets the amygdala over time.
The research suggests that the mechanism works the same way whether you write the affirmation, say it out loud, or read it from a card. What matters is repetition and personal relevance, choosing words that connect to something you care about. Generic positivity does not land the same way a sentence about something you care about does. The more specific the statement, the stronger the signal. pubmed.ncbi.nlm.nih.gov/2654ā¦
CardioCarll retweeted
The cortisol spike from exercise suppresses the next cortisol response from a stressor.
Exercise before stressful things.
Are E-Cigarettes Really Safe?
@NEJMClinician Editor-in-Chief Raja-Elie Abdulnour, MD (@BageLeMage), discusses a population-based study investigating the relation between e-cigarette use and lung cancer risk. Read the key results and comment from Sara Turbow, MD, MPH: jwat.ch/4f2rgJF
Visit clinician.nejm.org to discover what else matters this week, including:
š Exercise for Hypertension: What Works Best?
š¬ Colonoscopy vs. FIT for Colorectal Cancer Screening
šØ Oxygen After Cardiac Arrest: Conservative vs. Liberal Strategy
š· Alcohol Consumption Remains Common during Pregnancy
Compelling cardiac risk markers can lurk even in the simplest of places (a single line), overlooked through decades of scientific research.
A very impressive discovery of a new ECG marker for sudden cardiac death validated in 3 different cohorts and linked to benefit of defibrillator, an outgrowth of human research ingenuity and AI deep learning nature.com/articles/s41586-0ā¦
Bad news: strong associations nationwide between cancer risk and living near a nuclear power plant (new work from Petros Koutrakisās lab)
"We get emails from families saying that big percentages of people they know get cancer. But of course, these are anecdotal," says Dr. Yazan Alwadi. His new research on cancer risk and proximity to Nuclear power plants may finally give them an answer.
gsas.harvard.edu/news/does-pā¦
Have standardized tests been demonized for their limitations? UC professors ask for reinstatement of standardized testing in admission due to poor math skills share.google/AKVCb8Q2oL4TdGeā¦
CardioCarll retweeted
@CircRes May 22nd Issue is Out! ahajrnls.org/3wPOBJJ
Cover: Artistic visualization of Fb state transitions, illustrating the shift from homeostatic to activated profibrotic states during HF driven by mineralocorticoid receptor signaling.
CardioCarll retweeted
National Science Foundation. Cut in half.
āThe White House seeks to slash the NSF budget by nearly 55%, to $4 billion.ā nature.com/articles/d41586-0ā¦
Really proud of Dr. Ramalingam for not only generating but also demystifying this very complicated dataset. Wishing he had been able to visit from Hungary to receive this honor at SOT in person himself.
CardioCarll retweeted
Congratulations to Dr. Brittany Reynolds, a former Trainee in the Laboratory of Dr. Alex Carll, who received the Paper of the Year Award from the Cardiovascular Toxicology Specialty Section of the Society of Toxicology at their recent annual meeting.
CardioCarll retweeted
Next, at #SOT2026, on Tuesday afternoon, Dr. Brittany Reynolds, a former PhD student in the Laboratory of Dr. Alex Carll, will present her thesis research showing that beta-blockade prevents e-cigarette-induced arrhythmias during and after pregnancy. #Toxicology
CardioCarll retweeted
The plastic pollution crisis and unanswered questions about the increased risk of
āCancer
jci.org/articles/view/203775
āNeurodegenerative diseases
jci.org/articles/view/204824
@jclinicalinvest
CardioCarll retweeted
New science is in: Intense wildfire š„ smoke during pregnancy is linked to a higher risk of autism. š¤°šØ Itās more than just "bad air"āitās about our children's development.
laist.com/news/climate-envirā¦
CardioCarll retweeted
Omega-3s reduce self-reported aggression.
In a randomized trial, 6 weeks of omega-3 significantly lowered self-reported aggression scores vs. placebo.
Omega 3ās are 20% of the dry weight of the brain, so supplementing may change how the brain is able to respond to provocation.
CardioCarll retweeted
The time of day for cancer immunotherapy is associated with major outcomes. Early is better. Results from a randomized trial of lung cancer, backs up the importance of our circadian rhythm and immune system
nature.com/articles/s41591-0ā¦
CardioCarll retweeted
Discovery of a maladaptive heart-brain-immune system loop after a heart attack, and the ability to modulate it
cell.com/cell/fulltext/S0092ā¦
CardioCarll retweeted
EPA just made its priorities clear.
Instead of valuing the lives saved by limits on deadly air pollution, the agency has stopped counting those benefits altogether. Now it is only counting what pollution rules cost companies. š”š”
When profits matter more than peopleās lives, public health loses.
CardioCarll retweeted
EPA Administrator Lee Zeldin has proposed toāÆdoubleāÆthe amount of formaldehyde acceptable for our families to breathe. š”š”š”
actnow.momscleanairforce.orgā¦..



























