Professional news from the Cancer Evolution Group @cwru.
Cleveland, OH
Joined September 2015
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Chris McFarland retweeted
Our recent @PRX_Life paper was selected as the very first journal cover and it looks great :)
Past thread explaining why we're are just so excited about this result below:
Incredibly excited that our paper examining the role of ecological interactions in preexisting drug resistance is out! We tackle the apparent paradox between the cost of resistance in the absence of treatment, and the ubiquity of preexistence. 1/20
Link: go.aps.org/4c5FmH4
Chris McFarland retweeted
Excited to share new paper led by postdoc @JeffMaltas (on the job market!) out today in @PRX_Life (1/4 🧵)
Frequency-Dependent Ecological Interactions Increase the Prevalence, and Shape the Distribution, of Preexisting Drug Resistance
#cancer #ecology
journals.aps.org/prxlife/abs…
Chris McFarland retweeted
Excited to showcase our poster at #AACR on Tuba-seq and the latest innovation in lung cancer discovery! Visit Section 26 to learn more. #AACR24 #AACR #cancerresearch #lungcancer @AACR @CancerEvoLab
@cwru @CWRUSOM @CWRUPostdocs
Chris McFarland retweeted
Add in some good statistical approaches to fit non-monotone growth rates and you have a nice complete method. Comments welcome!!
Chris McFarland retweeted
Proud of @cwrumstp student Eshan King for publishing 1st thesis paper this week @PLOSCompBiol!
In it, we explore how #FitnessSeascapes encode multple #evolutionary trade-offs during changing drug dosing (either in space or time).
Short thread
journals.plos.org/ploscompbi…
Chris McFarland retweeted
Come check my poster @aacr NCI-EROTIC international conference on Molecular Targets and Cancer Therapeutics A177
#Boston @CancerEvoLab
Chris McFarland retweeted
first time presenting this exciting new work from @colincess! he will have to do a #tweetorial when the paper comes out! #mathonco
Stacey now shows cool just accepted work in @PLOSCompBiol on modeling the tumor-immune ecosystem at the tissue scale. Love the idea of using a feed forward network to make macrophage state decisions facilitating a massive speed up in computational time!
Chris McFarland retweeted
Really happy to participate in #MathOnco23 ! What an exciting community!!
Next we have Nikolaos Dimitriou presenting, Investigating sedimentation in 3D cultures with an integrated experimental-computational framework #MathOnco23
Chris McFarland retweeted
Happy to share our pre-print describing how frequency dependent interactions b/n resistance & sensitive cells affect the prevalence & distribution of pre-existing drug resistant cells. biorxiv.org/content/10.1101/…. @JeffMaltas @durmaz_aa @CancerEvoLab @hinczewskilab @CancerConnector
Chris McFarland retweeted
Christopher McFarland (@CancerEvoLab) is a cancer geneticist at Case Western Reserve University. We discuss tumour evolution, the accumulation of deleterious mutations in cancer, and the landscape of the cancer biology field.
anchor.fm/epistimones/episod…
Chris McFarland retweeted
TWEETORIAL on our new #radonc paper in @TheLancetOncol -- joint work from @CCLRI @MoffittNews @CWRUSOM 1/n
Pan-cancer prediction of radiotherapy benefit using genomic-adjusted radiation dose (GARD): a cohort-based pooled analysis
thelancet.com/journals/lanon…
@OncoAlert
Chris McFarland retweeted
Thrilled to share that I joined @WeizmannScience to start my own lab! We will study how gene regulation shaped human evolution: gokhmanlab.com. I am looking to recruit👩🔬👨🔬, so please RT!
Chris McFarland retweeted
Please consider writing a blog post for the Mathematical Oncology Blog, @mathoncoblog.
We've had 41 posts, with an upper bound of several thousand views.
To submit, reach out to @dbasanta or one of the other editors (blog.mathematical-oncology.o…).
Chris McFarland retweeted
A letter issued by the American Physical Society in support of Professor Gang Chen.
Please kindly retweet.
cdn.fbsbx.com/v/t59.2708-21/…
Chris McFarland retweeted
I'm recruiting! training.vbc.ac.at/phd-progr… imba.oeaw.ac.at/research/ant…
Chris McFarland retweeted
This week in #MathOnco 151: Information theory, clonal expansion, evolutionary dynamics, plasticity, PKPD
thisweekmathonco.substack.co…
Chris McFarland retweeted
Really chuffed to share our latest @CR_AACR cover by @StroblMAR on his paper, Turnover Modulates the Need for a Cost of Resistance in Adaptive Therapy. I believe this is the 1st time a phase-plane has made it onto the cover of Cancer Research! @mathonco cancerres.aacrjournals.org/c…
Chris McFarland retweeted
Today we mourn the loss of Professor Angelika Amon. She was a remarkable person, an incredible and creative scientist, a lively and spirited colleague, and devoted mentor. Her impact and legacy live on, and will be perpetuated through everyone she touched.
Chris McFarland retweeted
Protip: You can use Zoom virtual backgrounds to work in lab while working from home!
Chris McFarland retweeted
Excited to share our latest work investigating why tumours frequently double their genomes and how we can exploit this to identify cancer genes. #TRACERx @Saioa_l @CharlesSwanton @uclcancer @TheCrick
Interplay between whole-genome doubling and the accumulation of deleterious alterations in cancer evolution (López et al.) go.nature.com/3aBqdhf
