🚨 A few things to note about Anagen's topical diazoxide 1. Any claims about past human performance are likely false. We're the first to do this at scale. Several other compounding pharmacies offer this medication, but almost nobody uses it because it's "lazily" solubilized. It uses an extremely high percentage of DMSO. DMSO is extremely irritating at high concentrations and serves as a powerful penetration enhancer (bad if you're trying to avoid systemic effects). 2. The Anagen lab team worked for months and tested 70+ different vehicles to find our final formulation. Our goal was to dissolve the highest % of the drug possible while remaining non-irritating. We found it non-irritating and hope you will too. Our formulation is first in class in this respect. 3. We're very transparent that we haven't yet collected blood data for this product. We hope that will change this week. It will be public the moment we get the results. 4. It's easy/convenient to ignore the model we put up on the site (scroll down on the Diazoxide product page). TL;DR, even if *10%* of the applied diazoxide went straight into your blood (this would be astronomically high), you're 18x below what is seen at the 10,000 ng/mL threshold that typical oral doses of diazoxide reach. This is a MODELED estimate that we released ahead of testing Diazoxide on our own heads. It's not predictive of individual response. But this could be a very different beast (in a good way) than oral diazoxide or topical diazoxide with very high concentrations of penetration enhancers. 5. We lead with "built for Minoxidil non-responders". We made diazoxide for the many patients we see who are frustrated with underwhelming results on Minoxidil. Your genes dictate your SULT1A1 activity. We think MINX could be the best drug in the world to solve this problem. We're *also* releasing our diazoxide to attack this same sult1a1/activation problem from another angle. It's best for: - Minoxidil non-responders (insufficient SULT1A1 activity, affects many) - People who respond to Minoxidil but are looking to maximize the hair growth effects associated with SUR2B/Kir6.1 opening (how minoxidil works). 6. Diazoxide does NOT require sulfation for activation. This is complete nonsense. It's sulfate-conjugated metabolites are inactive and do not contribute to its pharmacological effects. They're relevant to clearance of the drug. SUR subunits (the stuff that grows hair!) is activated directly.

n=3 diazoxide blood data incoming from myself, @andrew_bakst and @VerbinnenAndrew next week. in the meantime, put a model on the site for anyone to explore possible blood levels relative to blood glucose/pressure effects. scroll down for the modeled serum effects