Herdsville stickers are a thing now:
youtu.be/6W-J5Gxu-G0?si=aRbN… via @YouTube
Cameron Crain retweeted
🚨 VANDERBILT WALK-OFF FUMBLE RECOVERY IN THE END ZONE
NC STATE FUMBLED WHILE RUNNING OUT THE CLOCK 😳
Cameron Crain retweeted
Friedberg: New study shows enzyme reverses skin age from 70+ years to 31
Chamath: That’s a $2T market.
Did Scientists Just Discover How to Reverse Skin Aging!?
“CML is kind of the predominant molecule that gets formed in this extracellular matrix that's driving aging, and nothing breaks it down.
So these scientists set out to try and create an enzyme, an enzyme is a protein that breaks something down, that can break down CML.
And so these guys kind of went out and they took the target, which is CML, and tried to figure out, ‘Okay, how do we actually degrade CML, clear that extracellular matrix, and reverse aging?’
They started to test it on the proteins that we would find in our body, casein, collagen, retinal proteins, which are in your eye, hemoglobin, and they were able to get rid of 52 to 97% of the CML, just degrade it away.
And then they found several sites where they were able to degrade over 90%.
And then they took actual human skin from elderly patients that had donated their skin, and they put this enzyme onto that skin, and they were able to eliminate 55% of the CML on the skin, basically reverse the skin's age down to the age of a 31-year-old, this is from greater than 70-year-old patients, just by putting this enzyme on the skin.
And so it's kind of a groundbreaking demonstration of combination of AlphaFold, what's called directed evolution, where you change the order of the DNA that changes the structure of the protein to test different proteins, do high throughput screening, and ultimately make a novel protein that doesn't exist in nature today that can do something pretty profound for human health.”
Chamath:
“It will be a trillion-dollar market. If you can create a cream…”
Friedberg:
“I mean, dude, if you could put this enzyme literally on your skin and have it absorb in…”
Chamath:
“Game over. That alone is $2 trillion.”
A boy of summer. Baseball season in full swing.
10 years old. Facing a pitcher built to terrify Little Leaguers.
I didn't swing. Not once.
'You forfeited your courage. That's the part that stings.'
It was the last time I would go down not swinging.
open.substack.com/pub/camcra…
Bestselling author, happiness researcher Arthur Brooks gives Class of 2026 a special homework assignment news.vanderbilt.edu/2026/05/…
The way of the founder is to obsess on understanding all aspects of the problem while staying open-minded to the solutions that emerge.
The way of the founder is to wake up, take a moment express your gratitude for being alive, remember that the day owes you nothing, and then getting on with building the change you want to see in the world.
Rick Rubin: "Make what you love, not what you think people will like"
"If you want to live in a creative way, which will benefit everything in your life, be a better person in your family, do a better job starting a new business, it's all the same. I don't really know anything about music. It's more a way of looking at the world and wanting it to be the best it could possibly be. And doing whatever it takes to be the best it could possibly be."
Rubin shares how his career happened:
"From the beginning, I never thought any of the things I'm doing were possible or realistic. I just did things out of the love of them, thinking I would have real jobs. That my passion would be my hobby, and I'd have a job to support my hobby. And it just magically turned out different than that without me knowing it was possible."
On why some things connect and others don't:
"The stars line up at certain times for certain things to happen. Sometimes you can make something great, and it doesn't connect for whatever reason. Sometimes you make two things you think are the two best things you've ever made. One of them connects with the world. One of them doesn't.
And it might not have anything to do with what's in the art. It might be that it came out the same day as something else. Or there was a bigger story at the time. There's so much to it that we don't understand."
He continues:
"All we can do is make something good and put it out and hope for the best. That's all there is. We never know why things work. Even if you make a piece of art and it works, you may not know why."
On talent versus work ethic:
"There are a lot of talented people who never make it because they don't have the work ethic. It's not just talent, talent's a piece. And you could argue for some people, the work ethic trumps the talent."
Rubin explains what real collaboration is:
"Having worked with a lot of bands, I see there's often this friction where people are trying to get their idea in. That's not a collaboration. A real collaboration is when everyone who's there is working together towards whatever is the best thing for the whole.
Whether it's your idea or someone else's idea, it doesn't matter. If you're invested in the collaboration, you want the best idea to win. You don't want your idea to win."
On what makes art great:
"What makes it great is the personal. With all of its imperfections. With all of its quirkiness. That's what makes it great. How you see the world that's different from how everyone else sees the world. That's why you're an artist. That's your purpose in sharing your work with the world."
He warns against being derivative:
"There are these derivative voices where they're finding what they think other people want to hear, and they start saying it because they've heard other people say similar things that are now successful. Even if they have some short-term success doing that, it's not revolutionary. It doesn't change the world. It doesn't last.
The people who you first see and you might not like that you come to like because you don't understand them at first, those are the ones that change the world. Those are the ones you dedicate your fandom to for life."
Rubin shares his philosophy on taste:
"You can't second-guess your own taste for what someone else is going to like. We're not smart enough to know what someone else is going to like. To make something thinking, 'Well, I don't really like it, but I think this group of people will like it,' it's a bad way to play the game of music or art. You have to do what's personal to you. Take it as far as you can go. Really push the boundaries. And people will resonate with it if they're supposed to resonate with it."
He describes creativity as catching waves:
"We're really talking about magic. The universe conspiring on our behalf if we let it. Being in this flow of catching these waves that anyone can catch. If you're trying to catch it, you're open to it, you see it coming, you take off on every chance you get. And sometimes the ride happens. It's remarkable how it happens. It doesn't come from preconception. It's not an idea. It's through the doing."
Rubin explains how ideas exist in the universe:
"Have you ever had that experience where you have an idea for something, you don't do it, and then six months later you see someone else has done it? It's not because they took your idea. It's that it's time for that, and you can act on it or not. The best artists are the ones who have the best antenna for this material that's available. It's coming through. The best comedians see the best jokes. They see them coming. We all live in the same world; the way you see it, you have the best joke because you see it best."
He closes with how to stay open:
"If we listen to what's going on around us, you can overhear a conversation in a coffee shop, and it is the setup for an idea you're working on. You hear a phrase you don't commonly use. My experience is: when you are open and looking for these clues in the world, they're happening all the time. And they're happening often right when you need them."
I didn’t just recognize the kids in that basement.
I was one of them.
Dice. Maps. Alignment.
Choosing who you want to be.
New piece on Stages:
What the Opening Scene of Stranger Things Taught Me.
open.substack.com/pub/camcra…
#strangerthings #substack
Imagine using solar in space for powering data centers, and, well, space to cool it…
Gavin Baker: "the most important thing that’s going to happen in the world in the next three to four years is data centers in space."
If this ever happens, SpaceX is the only company that can actually build this.
They're possibly going public in mid 2026 at a $1.5 trillion valuation, the largest IPO ever.
SpaceX expects to use some of the funds raised in the IPO to develop space based data centers, including purchasing the chips required to run them.
Elon Musk has publicly confirmed that "SpaceX will be doing" orbital data centers, and the company is already testing NVIDIA H100 GPUs in space.
SpaceX is currently seeking a valuation of $800 billion in private markets.
A $1.5 trillion IPO represents roughly an 1.9x jump from that valuation.
But here's the thing, if Gavin's right and space data centers become the foundational infrastructure layer for AI compute, that valuation could still look cheap down the road.
Think about it this way, every AI company that wants unlimited, low cost compute at scale would need SpaceX's launch capacity and Starlink infrastructure.
You're not just buying a rocket company, you're buying the pipe for the next era of AI infrastructure.
What the Mitochondria Wanted
Turns out that my cells had notes on healing:
substack.com/home/post/p-179…
And if you really want to know how Mitochondria work, check out @ChrisMasterjohn chrismasterjohnphd.substack.…













