Probing the unknowns of translation and mRNA biology using -omics methods. PI: @translatomics Starting September 2021 @humantechnopole https://xitter.cf/t.co/oqve1Ff0na
Joined June 2021
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RNA goes up, translation goes down...🤔
Here we investigate this phenomenon when depleting DDX3X, and we find that those are stabilized mRNAs.
GC content in CDS seems to drive this phenomenon, in cell lines as well as in vivo and in many other datasets.
Monitoring mRNA dynamics after DDX3X depletion indicates translation suppression followed by mRNA stabilization, with GC content in the CDS being a strong predictor of mRNA stabilization ➡️ embopress.org/doi/full/10.10… @translatomics @CalvielloLab @humantechnopole #RNAbiology
Calviello Lab retweeted
Job alert 🖥️🖥️🖥️:
Bionformatician in Functional Transcriptomics
careers.humantechnopole.it/o…
Join my interdisciplinary lab @CalvielloLab @humantechnopole to marry machine learning, signal processing and genomic data science, and push the limits of high resolution transcriptomics!
A pleasure to contribute to this study, big congrats to all!
1/ This @biorxivpreprint (biorxiv.org/content/10.1101/…) is now out cell.com/cell-reports/fullte…
This was a labor of love, and I am grateful to all the authors for sticking with the project and seeing it through (especially Amy Campbell, @RobertoAlbane14, and @translatomics)
Go Roberto, go!
👏Congratulations to our Roberto Albanese (@CalvielloLab) who presented his poster at the Biological Data Science meeting @cshlmeetings in NY about "De novo functional transcriptomics with RNA-seq and Ribo-seq".
Calviello Lab retweeted
Academia is this, academia is that...you know what academia is for us? Fun, Multidisciplinary, Transparent, Innovative and fundamentally Important.
Do you agree with this and want to merge integrative -omics approaches in #mRNA research and top-notch #AI methods? Come meet us!!!
🚨 Postdoc position 🚨 @humantechnopole
🤖 Transformers and #AI to give biology a good push... It’s time to take analysis methods to the next level!
Join us (@jug_lab) and and #mRNA master @translatomics to make this dream become reality!
bit.ly/3IeL36l
New Postdoctoral position available! Let's use the power of computing and -omics technologies to dissect life after transcription.
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Technician position available @CalvielloLab @humantechnopole in Milan, to probe translation regulation at -omics scale. If the last couple of years have convinced you that what happens to RNA matters, come join us! Spread it like wildfire 🔥🔥🔥: careers.humantechnopole.it/o…
Sometimes you express a transcription factor and you get translated NMD targets!
A little contribution from @translatomics (using #ORFquant & #RiboseQC) in this study led by @JagannathanLab about dynamics of DUX4 functions in human cells, as a model for #FSHD. Congrats to all!
Super excited to share our latest work!! 🎉
The myopathic transcription factor DUX4 induces the production of truncated RNA-binding proteins in human muscle cells biorxiv.org/content/10.1101/…
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Come work with us! Projects available in the lab will deal with quantifying different modes of gene regulation, heterogeneity of translating ribosomes, transcript isoform specific functions and proteogenomics applications!
We are offering 18 fully funded #PhD fellowships to young scientists who wish to undertake a doctoral degree in #ComputationalBiology, #Genomics, #Neurogenomics & #StructuralBiology.
Full details here: bit.ly/3pO2aEy
Apply via @semm_it website bit.ly/3gy5ijw
