Very proud of Dr. @JLinaresA, oncologist in our lab, for winning the Young Talent Award from @ufvmadrid and @merck_es!! @hospitaldelmar @HMar_research @the_prbb

7/9 🔬🩺POSTN expression is increased before and/or after treatment in non-responsive #FOLFOX treated #CRC patients. Therefore POSTN could be used as biomarker of resistance to #oxaliplatin in #colorectalcancer.

6/9 🧪In particular, we found that POSTN isoform 4 (POSTNi4) is the splicing variant most upregulated after treatment. In vivo, #CRC tumors engineered to enhance secretion of POSTNi4 turned resistant to treatment with #oxaliplatin.

5/9 🏩🩺Remarkably, our team discovered in a #colorectalcancer patient cohort that POSTN is enriched in CMS4 tumors and its presence in the stroma associates with decreased disease-free survival.

4/9 🧬The gene encoding for the extracellular matrix protein Periostin (POSTN) is robustly upregulated within aFIB-RS and correlates with #TGFbeta activity in #CRC patients. This implies that POSTN expression could detect tumors with elevated TGFbeta activity.

3/9 🧬🧬Platinum uptake induces a pro-tumorigenic genetic program (aFIB-RS) in CAFs through the autocrine activation of #TGFbeta pathway. Interestingly, aFIB-RS is enriched in #CRC patients that do not respond and relapse after adjuvant platinum-based #chemotherapy.

2/9 🔬Using a technique for metals detection in geological samples (LA-ICPMS), we realized that CAFs in tumors from #colorectalcancer (CRC) patients retain a substantial amount of platinum for more than 2 years after #chemotherapy. @uniovi_info @JorgePisonero

7/9 🏩💊POSTN expression is increased before and/or after treatment in non-responsive #FOLFOX treated #CRC patients. Therefore POSTN could be used as biomarker of resistance to #oxaliplatin in #colorectalcancer.

6/9 In particular, we found that POSTN isoform 4 (POSTNi4) is the splicing variant most upregulated after treatment. In vivo, #CRC tumors engineered to enhance secretion of POSTNi4 turned resistant to treatment with #oxaliplatin.

5/9 🏩Remarkably, our team discovered in a #colorectalcancer patient cohort that POSTN is enriched in CMS4 tumors and its presence in the stroma associates with decreased disease-free survival.

4/9 The gene encoding for the extracellular matrix protein Periostin (POSTN) is robustly upregulated within aFIB-RS and correlates with #TGFbeta activity in #CRC patients. This implies that POSTN expression could detect tumors with elevated TGFbeta activity.