@CaloLabMIT

@MITBiology studying #RNA, assembly and function of the #Ribosome, and RNA involvement in #Development and disease.

 Cambridge, MA
calolab.mit.edu
Joined January 2018
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  • Following15
  • Followers341
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Excited to share our latest work in collaboration with @PauliGroup: A dual ribosomal system in the zebrafish soma and germline. Check it out! biorxiv.org/content/10.1101/…

A dual ribosomal system in the zebrafish soma and germline

Protein synthesis during vertebrate embryogenesis is driven by ribosomes of two distinct origins: maternal ribosomes synthesized during oogenesis and stored in the egg, and somatic ribosomes,...

biorxiv.org
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Targeted Degradation of CDK9 Potently Disrupts the MYC Transcriptional Network biorxiv.org/cgi/content/shor… #biorxiv_cancer
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Check out our latest preprint (papers.ssrn.com/sol3/papers.…). We established a connection between defects in tRNA splicing and non-syndromic orofacial clefts. This research was a multi-team collaborative effort led by Michaela Bartusel (@MichiBar2Cell).
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Check out our latest story. A groundbreaking study by PhD student Jade Varineau offers insights into the mechanisms underlying splicing stress response. journals.biologists.com/dmm/… Thanks, @MITBiology for the News Brief biology.mit.edu/news-brief-c…
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Proud of Fardin and @DiegoDetres for their accomplishments. Thanks, @MolecularCell for highlighting their work and scientific journey. Meet the Authors: cell.com/molecular-cell/full…

Meet the Authors: Fardin Aryan, Diego Detrés, and Eliezer Calo

We talk to co-first authors Fardin Aryan and Diego Detrés along with lead contact Eliezer Calo about their paper “Nucleolus activity-dependent recruitment and biomolecular condensation by pH sensing”...

cell.com
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Online Now: Nucleolus activity-dependent recruitment and biomolecular condensation by pH sensing dlvr.it/Sz70T0
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Check out our latest story on the nucleolus. A terrific work by Fardin Aryan and @DiegoDetres @MolecularCell @MITBiology Nucleolus activity-dependent recruitment and biomolecular condensation by pH sensing: Molecular Cell cell.com/molecular-cell/full…
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Thanks to @MIT News for highlighting our work! news.mit.edu/2023/study-expl…

Study explains how part of the nucleolus evolved

MIT biologists discovered that a scaffolding protein called TCOF1 is responsible for the formation of a biomolecular condensate called the fibrillar center, which forms within the cell nucleolus.

news.mit.edu
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A new study from the lab identified the scaffold of the nucleolar fibrillar center and provided a compelling model for how condensates might evolve. This is the work of @nimajaberi_ and @iambyronic Cell Reports cell.com/cell-reports/fullte…

An evolutionarily nascent architecture underlying the formation and emergence of biomolecular...

Jaberi-Lashkari et al. present a model for the evolution of biomolecular condensates by showing that a recently emerged condensate relies on a self-assembling scaffold rather than on many co-intera...

cell.com
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Check out our latest preprint. A super interesting story about the structure and evolution of the nucleolus. kudos to @nimajaberi_ and @iambyronic for this work. TCOF1 is a single-component scaffold of the nucleolar fibrillar center biorxiv.org/content/10.1101/…

TCOF1 is a single-component scaffold of the nucleolar fibrillar center

Many of the biological structures that exist across the tree of life are built on self-interacting scaffolds, from the actin cytoskeleton to the collagen extracellular matrix. Intracellular membran...

biorxiv.org
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Thank you @MIT News for featuring our work! news.mit.edu/2022/low-comple…. @MITBiology @nimajaberi_ @iambyronic

Biologists glean insight into repetitive protein sequences

MIT biologists found a way to identify and study low-complexity regions of proteins. The technique allows them to analyze similarities and differences between LCRs from different species, and helps...

news.mit.edu
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Our lab manuscript on LCRs has been published @eLife A unified view of low complexity regions (LCRs) across species doi.org/10.7554/eLife.77058. Kudos to @nimajaberi_ and @iambyronic for such amazing work! @MITBiology

A unified view of low complexity regions (LCRs) across species

Disparate functions of low complexity regions of proteins can be understood through a global view of their sequences, features, and relationships across different organisms and biological contexts.

elifesciences.org
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Check out our lab's newest preprint. A holistic approach to understanding the LCR sequence space within and between species. This is the works of two incredibly talented graduate students @nimajaberi_ & @iambyronic. @MITBiology biorxiv.org/content/10.1101/…

A unified view of LCRs across species

Low complexity regions (LCRs) in proteins play a major role in the higher order assemblies of organisms, such as the nucleolus and extracellular matrix. Despite recent focus on how certain features...

biorxiv.org
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Very excited to share our work on DNA-PKcs' role in rRNA processing and haematopoiesis! Collaborations with @Zha_Lab and @raflynn5 really made this story great. nature.com/articles/s41586-0…
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Happy Halloween!! Look at our FACE SEPARATION pumpkin complete with liquid droplet and FRAP assays! @MITBiology
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@MITBiology
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Loving this piece by John Wallingford about how #DevBio is "fundamental to the human experience" @___SDB___ cell.com/developmental-cell/…

We Are All Developmental Biologists

Humans have sought to understand the embryo for millennia. Paradoxically, even as technical and intellectual innovations bring us ever closer to a transformative understanding of developmental...

cell.com
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The Calo Lab knows how to dance the night away! Had a blast partying with the @MITBiology community!
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Good results? Bad results? No results? Doesn't matter. Our answer is ice cream. #PhDLife #PhDChat #Research @MITBiology @benandjerrys What's your snack of choice on Friday? – at Cambridge, MA
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Congrats @Arish__Shah for well communicated 3 minute talk about the importance of maternally deposited material!
MIT Biology@MITBiology23 Apr 2019
Grad student @Arish__Shah  uses zebrafish to investigate maternally-contributed molecules as a member of the @CaloLabMIT. He’s our final contestant in today’s Science Slam, so if you’re sitting in the audience, don’t forget to vote for your favorite talk!
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