@calico

Calico is a research and development company tackling one of life's greatest mysteries, the biology that controls human aging.

calicolabs.com
Joined June 2016
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As a Principal Data Scientist at Calico, Alejandro Granados builds computational methods that help move promising discoveries from our labs into Calico's translational programs. We asked Alejandro what he enjoys most about working at Calico. calicolabs.com/life-at-calic…
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We look forward to connecting with pediatric neurologists and discussing research on Vanishing White Matter at the @ChildNeuroSoc Annual Meeting in Montréal, October 14-17. Stop by Booth 1319 to meet our team and pick up educational materials.
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We're thrilled to see Carmela Sidrauski, Ph.D., Distinguished Principal Investigator at Calico, recognized as one of @endpts 20 Women Changing Biopharma! This honor highlights her scientific leadership in reshaping our understanding of how cells respond to stress. (1/6)
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As Carmela noted when reflecting on the science, “We’re just getting started with this mechanism.” Read Carmela’s profile in Endpoints: endpoints.news/special-repor… (5/6)

Meet 20 women changing the biopharma industry, from oncology to rare disease

20 women leading biopharma breakthroughs: gene therapy, record IPOs, pancreatic caner drugs and MASH launches.

endpoints.news
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Fosigotifator is an investigational drug. It has not been approved by the FDA or any other regulatory authority. Its safety and effectiveness have not been established. (6/6)
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Thank you to our early-career scientists for bringing your energy, fresh perspectives, and spirit of curiosity. We're grateful you're here! Here are some moments from our recent Postdoc Summit. #NationalPostdocAppreciationWeek
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September is #LeukodystrophyAwarenessMonth. Vanishing White Matter is a rare, progressive leukodystrophy that usually appears in early childhood. There's currently no approved treatment.
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Together with our partners at @ULFUnited and the Vanishing White Matter Families Foundation, we’re working to increase awareness and understanding of the disease and support the needs of this community. #VanishingWhiteMatter #Leukodystrophy #LeukoAware
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This month marks 13 years since Calico’s start. While our mission hasn't changed – to understand the biology of aging and use what we learn to help people live longer, healthier lives – our team has grown a lot since then.
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Our work now spans clinical- and early-stage programs across several aging and age-related disease areas, all of it building on the fundamental research that comes first. Thank you to our team, our collaborators, and everyone else who helped us get here.
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Read more about our story and where we’re headed next: calicolabs.com/story/our-sto…

Our Story: Taking a long-term view on tackling aging and increasing healthspan - Calico

Aging is the greatest risk factor for the world’s most common health problems, yet understanding its biology remains limited by its immense complexity. ...

calicolabs.com
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A new method for tracking protein-protein interactions in real time in living cells could open unexplored possibilities for understanding how cellular processes change with age. (1/9)
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Additional contributors include Alfred Millett-Sikking, Magdalena Preciado Lopez, Aaron Nile, Prashant Rao, Zena Jensvold, and Hannah Baddock. Lachlan Whitehead created this animation of TTM in action. (8/9)
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Read the preprint: biorxiv.org/content/10.64898… (9/9)

Triplet tumbling microscopy enables in situ quantification of protein complex assembly and dynamics

Protein-protein interactions (PPIs) mediate diverse cellular processes, but PPIs are typically characterized using reconstituted in vitro biochemical and biophysical approaches. Current approaches...

biorxiv.org
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