@CalgaryCobb

Developmental Biologist

 Calgary, Alberta
people.ucalgary.ca/~jacobb/Welcome.html
Joined May 2014
  • Tweets338
  • Following327
  • Followers208
50Media
Hard to believe this is finally out, made possible by the leadership of @m_osterwalder and wonderful collaboration with Marco and 26 other colleagues. Thanks to @LenPennacchio and @AxelVisel for being so supportive of the collaboration since 2017 (!).
Marco Osterwalder@m_osterwalder11 Oct 2024
It's a great pleasure that our study about the regulatory role of the Shox2 gene desert – a non-coding genomic region with multiple critical functions in embryogenesis - is finally out! #unibern #UCalgary #BerkeleyLab nature.com/articles/s41467-0… #devbio #enhancers #Shox2 #GeneDeserts

A gene desert required for regulatory control of pleiotropic Shox2 expression and embryonic survival

Nature Communications - Approximately a quarter of the human genome consists of gene deserts. Here, Abassah-Oppong et al. reveal the biological relevance, embryonic functions and underlying...

nature.com
1
2
9
656
Our part of this story began in 2011 when @AbassahOppong agreed to delete the LHB enhancer near the Shox2 gene as part of his PhD project. In those naive days, we thought this would explain how Shox2 expression is controlled in limbs. It turned out to be more complicated. . .
1
4
176
Big thanks to @carlyssullivan, Tabitha Festa-Daroux and Anja Itum for important contributions from our lab on the limb part of the story!
3
137
It's a great pleasure that our study about the regulatory role of the Shox2 gene desert – a non-coding genomic region with multiple critical functions in embryogenesis - is finally out! #unibern #UCalgary #BerkeleyLab nature.com/articles/s41467-0… #devbio #enhancers #Shox2 #GeneDeserts

A gene desert required for regulatory control of pleiotropic Shox2 expression and embryonic survival

Nature Communications - Approximately a quarter of the human genome consists of gene deserts. Here, Abassah-Oppong et al. reveal the biological relevance, embryonic functions and underlying...

nature.com
6
23
1
104
9,184
It’s been 13 years, so Brood XIX having a bit of a party near Elberton Georgia
1
235
Replying to @CNN
Tell me more!
2
1
1
2,414
Moving the lab to Paris in 2024, the following frozen (sperms) lines will soon be thrown away. Black, blue and red are different #InHoxWeTrust alleles. Anyone interested can contact Benedicte.Mascrez@unige.ch #NoFlowersByRequest 🙏RT genev.unige.ch/system/Duboul…
8
35
58
22,916
Cold October night in Calgary, and the demon dogs are out.
1
268
Midnight surprise appearance of aurora borealis from Christiansen Point on the North Coast Trail, Cape Scott Provincial Park, Vancouver Island.
1
5
600
Christensen Point
155
Looking Glass Rock, North Carolina. Still discovering Appalachian beauty spots after all these years.
1
7
494
13th edition of Barresi and Gilbert's Developmental Biology looks very nice, but still missing a Hox gene . . . #RespectforHoxb13 #InHoxWeTrust
1
1
1
12
862
Very nice to get the latest edition of Barresi and Gilbert's Developmental Biology textbook with the beautiful image of a human embryo from @BrivanlouLab on the cover. Also feeling a little old since I started teaching from the 8th edition.
5
409
Nice to have all these stories in one enjoyable read!
Denis Duboule@Duboule30 Mar 2023
Dedicated to all friends geneticists having fun 🙏🤘@GenesDev @the_Node #Shh #Hox #Gremlin #Pitx
2
404
Wow, thanks for the joy @Wilco. Such a great show in Calgary tonight after a 30 month Covid delay.
7
Yesterday’s sunset from Fording River Pass on the BC/Alberta border.
1
10
So excited to be at the joint #SDB2022 #PASED2022 meeting with the Cobb lab talking gene regulation in embryonic limb development. #yayscience #ashoxloadoffun @CalgaryCobb
2
11
John Cobb retweeted
U Calgary
@UCalgary27 Jun 2022
Remarkably complete mummified baby woolly mammoth, complete with skin and hair, discovered in Yukon permafrost -- named ‘Nun cho ga’ by Elders ow.ly/YQgc50JIq1t @UofC_Science
3
1
5
Excellent opportunity for research in stem cell biology and genetics. Positions in master and doctoral programs are currently available. If interested, please follow the instructions below
6
15
3
34
Great seeing the data on SHOX and SHOX2 in your study! Especially, since you can't get the former from a mouse!
Teichlab@teichlab3 May 2022
We are excited to announce our preprint on the spatial cell atlas of the entire human embryonic limb💪🦵biorxiv.org/content/10.1101/… We reveal the orchestral of genes during limb development in space and time, which also yields disease implication and mouse-human evolutionary insight

A human embryonic limb cell atlas resolved in space and time

Human limbs emerge during the fourth post-conception week as mesenchymal buds which develop into fully-formed limbs over the subsequent months. Limb development is orchestrated by numerous temporally...

biorxiv.org
2
Load more