@CJinLab

Medicinal chemistry lab focused on addiction and mental health disorders | Center for Drug Discovery | Research Triangle Institute

 RTI International, Durham, NC
rti.org/expert/chunyang-jin
Joined March 2015
  • Tweets60
  • Following84
  • Followers44
5Media
A generative deep learning approach to de novo antibiotic design - ScienceDirect sciencedirect.com/science/ar…
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The GPR88 Agonist RTI‐122 Reduces Alcohol‐Related Motivation and Consumption - Lovelock - 2025 - Addiction Biology - Wiley Online Library onlinelibrary.wiley.com/doi/…

The GPR88 Agonist RTI‐122 Reduces Alcohol‐Related Motivation and Consumption

In mice, RTI-122, a GPR88 agonist, reduced alcohol consumption in a two-bottle choice paradigm, which was prevented by Gpr88 knockout. In rats, RTI-122 decreased alcohol self-administration, reduced...

onlinelibrary.wiley.com
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Development of RXFP3 negative allosteric modulators which reduce alcohol intake in rats. A great collaboration with ⁦@BesheerLab⁩ . pubs.acs.org/doi/10.1021/acs…

Development of Diphenyl-1,2,4-Oxadiazole Analogues as Allosteric Modulators of the RXFP3 Receptor:...

Abstract. Relaxin-3/RXFP3 antagonism is a novel strategy for drug development to treat alcohol use disorder (AUD). We recently discovered the first-in-clas

pubs.acs.org
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Discovery of a novel series of GPR88 agonists based on the ‘reversed amide’ strategy. pubs.acs.org/doi/10.1021/acs…

Design, Synthesis, and Structure–Activity Relationship Studies of Novel GPR88 Agonists (4-Substit...

Abstract. The development of synthetic agonists for the orphan receptor GPR88 has recently attracted significant interest, given the promise of GPR88 as a

pubs.acs.org
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Our latest collaboration with @CJinLab @RTI_Intl. Targeting the relaxin system and implications for AUD treatment.
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Are APO structures with G proteins are all active-like structures? An inverse agonist of orphan receptor GPR61 acts by a G protein-competitive allosteric mechanism. nature.com/articles/s41467-0…

An inverse agonist of orphan receptor GPR61 acts by a G protein-competitive allosteric mechanism

Nature Communications - GPR61 is an orphan GPCR of interest for treatment of appetite disorders, such as obesity and cachexia. Here, the authors report structures of GPR61 in its active and...

nature.com
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I’m happy to share our recent development of GPR88 agonist RTI-122 with high potency and brain bioavailability. pubs.acs.org/doi/10.1021/acs…
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A first radioligand for GPR88 is available now. sciencedirect.com/science/ar…
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Jin’s lab retweeted
BryanRoth
@zenbrainest8 Sep 2022
Cool paper #GPCR nature.com/articles/s41380-0…
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I’m happy to share our recent results of GPR88 agonist in alcohol drinking behaviors. onlinelibrary.wiley.com/doi/…

The GPR88 agonist RTI‐13951‐33 reduces alcohol drinking and seeking in mice

GPR88 is an orphan G-protein-coupled receptor considered a potential target to treat brain diseases, but pharmacological tools in vivo are still lacking. We show that the novel brain penetrant...

onlinelibrary.wiley.com
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Jin’s lab retweeted
BryanRoth
@zenbrainest1 Aug 2022
New #gpcr structures--RXFP4 biorxiv.org/content/10.1101/…

A unique peptide recognition mechanism by the human relaxin family peptide receptor 4 (RXFP4)

Members of the insulin superfamily regulate a variety of biological processes through two types of target-specific but structurally conserved peptides, insulin/insulin-like growth factors and...

biorxiv.org
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The First Nonpeptide Antagonists for the Relaxin-3/RXFP3 System pubs.acs.org/doi/10.1021/acs…

Discovery and Characterization of the First Nonpeptide Antagonists for the Relaxin-3/RXFP3 System

Abstract. The neuropeptide relaxin-3/RXFP3 system is involved in many important physiological processes such as stress responses, appetite control, and mot

pubs.acs.org
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wpln.org/post/st-jude-making…

St. Jude making room for Ukrainian cancer patients in Memphis while helping place children across...

St. Jude's global arm is helping connect childhood cancer patients evacuating Ukraine with hospitals across Europe. Soon they may also come to the U.S.

wpln.org
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Drugs with halogens.
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Jin’s lab retweeted
Elon Musk
@elonmusk26 Feb 2022
Replying to @FedorovMykhailo
Starlink service is now active in Ukraine. More terminals en route.
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Excited to share that our RSA '22 symposium, AT THE CROSSROADS OF AFFECTIVE DISORDERS AND ALCOHOL USE DISORDERS: NEURAL TRANSMISSION, SUBJECTIVE AND NEURAL RESPONSE TO ALCOHOL, AND ROLE(S) OF STRESS, has been accepted. Ft. Beth Lippard, Andrea King, @BesheerLab, @drrajitastress
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Check this out! biospace.com/article/septern…
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Check out this job at RTI International: Postdoctoral Fellow - Medicinal Chemistry linkedin.com/jobs/view/28616…
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Jin’s lab retweeted
M. S. AtKisson@iGrrrl9 Jan 2022
A reminder: In a grant proposal, don't tell reviewers what you could perhaps do. Tell them exactly what you plan to do. If you don't know what you plan to do before writing, you have violated the first rule: No one should write a grant proposal without thinking first.
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