Passionate about genomics, tech dev, climate change, & social justice. Avid diver. Works in urchins; dreams of corals. 🏳️🌈
Durham, NC
Joined April 2020
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- Following247
- Followers77
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Carl Manner retweeted
People say science twitter has lost its mojo, but we just main-character'd a guy for being insufficiently committed to mentoring, and it was the one guy who has a public, standing offer to be an informal advisor to literally any scientist in the world
Carl Manner retweeted
The 7 hottest days on Earth in the last 100,000+ years all happened in the last week:
July 6 ~ 17.23°C / 63.01°F
July 7 ~ 17.20°C / 62.96°F
July 4 ~ 17.18°C / 62.93°F
July 5 ~ 17.18°C / 62.92°F
July 8 ~ 17.17°C / 62.90°F
July 10 ~ 17.12°C / 62.81°F
July 9 ~ 17.11°C / 62.79°F
Carl Manner retweeted
Three of the more costly and frequently used reagents in molecular biology are rolling circle amplification (RCA) mix, chemically competent MachOne (or other E. coli) cells, and Gibson assembly mix. Postdoc Julian Willis—who is starting his own lab in the UK soon—developed homemade recipes for each that reduce costs ~3x (or more at large-scale). Links to each recipe:
RCA mix:
docs.google.com/spreadsheets…
Chemically competent MachOne cells:
docs.google.com/spreadsheets…
Gibson assembly mix:
docs.google.com/spreadsheets…
Carl Manner retweeted
This recent talk features ChromBPNet, our upcoming flagship predictive sequence model of base-resolution chromatin accessibility profiles (ATAC-seq, DNase-seq, scATAC-seq cluster pseudobulks) with built-in de-novo enzyme bias correction. 1/
Can’t recommend this talk by @anshulkundaje enough. Also thanks to @broadinstitute for sharing on YouTube youtu.be/4zg5CuCPopU
Carl Manner retweeted
this was not at all depressing to write prospect.org/culture/books/2…
Carl Manner retweeted
Prime editors can tweak DNA in ways that Cas9 -- and even base editors -- cannot.
Clinical trials are expected to begin by 2025.
In the last few days, three papers have pushed the method forward.🧵
A friend gifted my partner a pez dispenser shaped like a poop emoji for their lactaid.
I’d this what it feels like to get old?
(Ab)Using the @plasmidsaurus sequencing service is sort of amazing. For $30!!!, I was able to rule out the presence of XX/X0, ZZ/ZW, and ZZ/Z0 chromosomal sex determination in the sea urchin I work with, and was able to generate some hypotheses to follow up on.
Carl Manner retweeted
Excited to share our latest coral paper nature.com/articles/s43705-0…
that looks into the link between lipid stores and symbiotic state in corals
#Symbiosis #corals @UTS_Science @UTSResearch
Carl Manner retweeted
I am BEGGING you to turn off any bots you created and have them stop voting at 12 p.m. ET. As it stands right now, I can't get into the form to turn it off. 😅
We'd love to give you another #MBLMarchMadness vote update, but we literally can not get into the form.
Who is winning? WE HAVE NO IDEA!
It's ROTIFER VS AXOLOTL — TAKE NO CHANCES! VOTE VOTE VOTE!!! go.mbl.edu/MarchMadnessVote
Carl Manner retweeted
We will win recognition in the end, but this transparent delay tactic is keeping us from the fair contract we deserve. Adequate childcare, int’l student protections, and COLA cannot wait: we call on Duke to live up to their DEI commitments and listen to their workers.
Carl Manner retweeted
No peer institution has taken such a hardline anti-union stance. With grad workers around the country (e.g. @gradworkersofBU, @33unitehere) winning elections by historic margins, Duke's tactic threatens to reverse the immense progress won by the grad union movement since 2016.
Carl Manner retweeted
BREAKING: Duke attys have indicated they intend to challenge the legal standing of grad workers as employees, aiming to reverse the NLRB’s 2016 Columbia decision. @DukeU: stop these reprehensible union-busting tactics, recognize our majority, and meet us at the bargaining table.
Carl Manner retweeted
told a joke on a zoom meeting and no one laughed so I said “wow everyone’s microphones must be muted because I didn’t hear any laughs” and someone goes “none of us are muted”
Carl Manner retweeted
I love this adorable little incubator. It heats and cools, can go from around ~4°C to 60°C and is very very quiet. Temp guage is off by half a degree so keep a wireless thermometer in there to adjust your setpoint, but pretty good for the money and so smol
a.co/d/dzpU9Ql
