@CESNE4

Study Center for Neurodegeneration (CESNE), University of Padua.

 Padova, Italy
cesne.biologia.unipd.it
Joined July 2022
  • Tweets140
  • Following156
  • Followers133
7Media
Call for Content: Don't forget to submit to Biology Direct's Collection 'Evolution of prokaryote virus defense'! Guest Edited by Nash Rochman, Tito Calì and Daniele Marcoccia @lab_cali biomedcentral.com/collection…
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Reminder: the plasmid to monitor simultaneously ER-MITO contacts and Ca²⁺ transfer at those contacts (developed with @NasuLab_IBC) is available on Addgene! 🔬✨Link: addgene.org/247995/…the list of additional organelle contacts to be monitored keeps growing… stay tuned! 🧬

SPLICa:ER-MT (High Affinity)

Plasmid SPLICa:ER-MT (High Affinity) from Dr. Tito Calì's lab contains the insert SPLICa ER-MT (h) and is published in Anal Chem. 2025 Sep 16;97(36):19848-19861. doi: 10.1021/acs.analchem.5c03831....

addgene.org
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Amazing Work (and application of SPLICS reporter) from Pernas Lab…plus reversibility and no artificial tethering🙌 nature.com/articles/s41564-0…

Toxoplasma effector TgROP1 establishes membrane contact sites with the endoplasmic reticulum during...

Nature Microbiology - The Toxoplasma gondii effector TgROP1 mimics host factors to bind VAPA/B, thereby establishing parasite–host ER contact sites.

nature.com
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Take a look at our last review on PMCAs and cerebellar Ataxia! @BioMedCentral Biology Direct! link.springer.com/10.1186/s1…

Plasma membrane calcium ATPases and cerebellar pathology: what’s the role in the ataxia?

Biology Direct - Ca²⁺ signaling is essential for neuronal development, migration, synaptic activity, spine plasticity, neurotransmitter release, membrane excitability, and long-term...

link.springer.com
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Replying to @NatMetabolism
👆👆👆A Must Read! Congratulations @AgostinisLab and team for the outstanding work! An elegant and highly relevant study uncovering disease mechanisms through lysosome–mitochondria contacts, a major step forward for the field. 👏
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BDH2-driven lysosome-to-mitochondria iron transfer shapes ferroptosis vulnerability of the melanoma cell states go.nature.com/4pIe8hF

BDH2-driven lysosome-to-mitochondria iron transfer shapes ferroptosis vulnerability of the melanoma...

Nature Metabolism - Rizzollo et al. show that BDH2 participates in iron distribution between cellular compartments, which sets the threshold for the ferroptosis vulnerability of the melanoma cell...

nature.com
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Call for Content: Don't forget to submit to Biology Direct's new Collection 'Evolution of prokaryote virus defense'! Guest Edited by Nash Rochman, Tito Calì and Daniele Marcoccia @lab_cali biomedcentral.com/collection…
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🚨 New Review Alert! 🚨
Our latest in CSH Perspectives in Biology explores when, where, and how calcium ions flow between organelles—and why this matters for cellular signaling & health. Read more 👉 #CellBiology #Calcium @cshperspectives google.com/url?q=http://cshp…
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Proud to share the collaborative work with @NasuLab_IBC & @Campbell_FPs (Robert E. Campbell)! Split biosensors have been developed to intrinsically monitor membrane contact & Ca²⁺ exchange simultaneously—no chemical fluorophores required! 👉 pubs.acs.org/doi/10.1021/acs…"

Bipartite Genetically Encoded Biosensors to Sense Calcium Ion Dynamics at Membrane–Membrane Contact...

Abstract. Self-complementing bipartite fluorescent proteins (FPs) are useful tools for the detection of protein–protein proximity and for localizing fluoro

pubs.acs.org
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🧠💤 Mitochondrial origins of the pressure to sleep. This is so cool—sleep deprivation increases ER–mito contacts (thanks SPLICS! 🙏➡️🔆⬅️). Congrats to the team! Turns out your organelles need rest too. 😴 Mind your contacts if you want to count sheep. 📄 nature.com/articles/s41586-0…

Mitochondrial origins of the pressure to sleep

Nature - Research on Drosophila neurons shows links between the need to sleep and aerobic metabolism, indicating that the pressure to sleep may have a mitochondrial origin.

nature.com
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🧪 We have a new publication out in @NatureComms. 🧪Great collaborative work involving @KclRandallMol, @dsb_unipd, @PhD_DSB_UniPD, @cnr_scitec, @humantechnopole. Here's the link nature.com/articles/s41467-0…

Microtubule association induces a Mg-free apo-like ADP pre-release conformation in kinesin-1 that...

Nature Communications - Kinesin-1 utilizes ATP-driven conformational changes to transport vital intracellular cargoes along microtubules. The authors use cryo-EM to reveal a missing structural...

nature.com
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New Online! Key challenges and recommendations for defining organelle membrane contact sites bit.ly/4lnIBP1
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🚨 New review out in Nature Reviews Molecular Cell Biology! Expert recommendations for studying organelle contact sites and introduce the concept of organelle contactome 🧬nature.com/articles/s41580-0… Huge thanks to editor Lisa Heinke for the support and guidance! 🙏@NatRevMCB

Key challenges and recommendations for defining organelle membrane contact sites

Nature Reviews Molecular Cell Biology - Membrane contact sites between organelles facilitate the exchange of ions, lipids and metabolites. This Expert Recommendation highlights recent advances in...

nature.com
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Call for Content: Don't forget to submit to Biology Direct's new Collection 'Evolution of prokaryote virus defense'! Guest Edited by Nash Rochman, Tito Calì and Daniele Marcoccia @lab_cali biomedcentral.com/collection…
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nature.com/articles/s41586-0…

PLA2G15 is a BMP hydrolase and its targeting ameliorates lysosomal disease

Nature - Lysosomal phospholipase PLA2G15 was identified as a physiological BMP hydrolase whose activity depends on unique esterification and stereochemistry of BMP and offers a potential...

nature.com
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nature.com/articles/s41580-0…

Recommendations for robust and reproducible research on ferroptosis

Nature Reviews Molecular Cell Biology - Ferroptosis is a non-apoptotic type of cell death that is induced by uncontrolled iron-dependent phospholipid peroxidation and has important roles in...

nature.com
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Being able to contribute in a very small part to @ccp4_mx has been one of the highlights of my career so far. So happy that this paper received enough views to be a Top Viewed Article. Read it here onlinelibrary.wiley.com/doi/… #TopViewedArticle @wileyinresearch

The CCP4 suite: integrative software for macromolecular crystallography

This article describes the Collaborative Computational Project No. 4 (CCP4). It is intended as a general literature citation for the use of the CCP4 software suite in structure determination.

onlinelibrary.wiley.com
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Join us for this wonderful international practical school. Great speakers and tutors. Register now school2025.cristallografia.o… #cryoEM #structural_biology #crystallography @AICryst @UniPadova
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🚀 New paper! 🧬✨Thrilled to share our latest work @cddpress, pushing the boundaries of imaging inter-organelle contacts in vivo! Incredible effort by our talented postdoc Lucia Barazzuol, in collaboration with @alessio_vagnoni and the Marisa Brini Lab. rdcu.be/efkYK🚀
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Dear old aspirin…. A new study shows it prevents metastasis by limiting platelet TXA2–mediated suppression of T cell immunity. From heart attacks to cancer... is there anything it can’t do? nature.com/articles/s41586-0…

Aspirin prevents metastasis by limiting platelet TXA2 suppression of T cell immunity

Nature - Inhibition of cyclooxygenase 1 releases T cells from immunosuppression by platelet-derived thromboxane A2, thereby enhancing the immune response against metastasis.

nature.com
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