Organoid co-culture and organ-on-chip systems are transforming how we study immune–epithelial interactions, enabling more precise, patient-relevant models of disease 🧬 🔗 doi.org/10.1093/cei/uxae004 #Immunology #Organoids #Microfluidics #PrecisionMedicine

Research in Crohn’s disease shows peripheral blood T cells are already less prone to apoptosis before reaching the gut, with reduced catalase activity contributing to this effect 🧬 🔗 vist.ly/5jhn5 #Immunology #CrohnsDisease #Tcells

📢 This open‑access study identifies PSMB8 as a biomarker predicting proton pump inhibitor response in paediatric eosinophilic esophagitis, supporting more personalized treatment decisions. 🔗 vist.ly/5ixam

🧬 How does ageing with frailty reshape immune responses? This open‑access study links altered neutrophil signalling to impaired chemotaxis and increased ROS/NET production, highlighting key features of inflammageing. 👉 vist.ly/5ihau #ImmuneAgeing26

Join us in celebrating 60 years of pioneering clinical and translational immunology research! Explore our special collection showcasing the most-cited and widely-read articles that shaped our legacy: vist.ly/5hjvm #CEIat60

This open‑access study shows the β‑blocker nebivolol prevents T‑cell exhaustion and boosts cytotoxicity against breast cancer cells via β₂‑adrenergic receptor–dependent signalling, highlighting a potential new immunomodulatory strategy. vist.ly/5h4ta

In this review, Mansi Patel and colleagues explore how long non-coding RNAs influence neuroimmune interaction in oral squamous cell carcinoma. 📖 doi.org/10.1093/cei/uxag007 #Immunology #CancerResearch #Neuroimmunology

Early splenectomy delays inflammation and reduces joint damage in a mouse model of autoimmune arthritis, highlighting a surprising protective role when done at early stages. 🧬 doi.org/10.1093/cei/uxae013 #Immunology #Autoimmunity #Arthritis

In Sjögren’s syndrome, salivary gland epithelial cells act not just as targets but as drivers of autoimmune inflammation. Their altered signalling and antigen‑presenting features can shape and sustain immune dysregulation. 🔗 doi.org/10.1093/cei/uxaf078

Could antibodies help prevent TB disease? A new study reports higher TB-specific IgA and IgG responses in exposed, healthy individuals than in patients with active TB. 🔗 doi.org/10.1093/cei/uxaf001 #TBResearch #Immunology #GlobalHealth

What does living past 105 look like immunologically? Increased Vδ1 TEMRA, CD8+ T and NK cells suggest a resilient immune system shaped by lifelong adaptation. 🧬 doi.org/10.1093/cei/uxad132

🧬 Could extracellular microvesicles help track rheumatoid arthritis activity? Anti-TNFα therapy reduced EMVs carrying disease-associated protein modifications, alongside improvements in disease activity, highlighting their potential as biomarkers. 🔬 🔗 doi.org/10.1093/cei/uxag044

IFNγ from activated CD4⁺ T cells is a key driver of B‑cell differentiation and autoantibody production in IMQ‑induced lupus mice. IFNγ deficiency dramatically reduced disease features, a promising immune pathway for future SLE therapies. doi.org/10.1093/cei/uxaf079

Altered B-cell homeostasis and elevated IL10/TNFA expression in #CIDP suggest chronic humoral immune activation. Immune markers also correlated with nerve fiber loss and disability, highlighting potential biomarkers of disease activity. doi.org/10.1093/cei/uxad103 #Neurology

Targeting T-cell integrins has become an important therapeutic strategy for autoimmune and inflammatory diseases. This review covers the biology of integrins and the latest advances in integrin-targeting treatments. 🔗 doi.org/10.1093/cei/uxad093

🔬 New research suggests that stronger IgA and IgG antibody responses may help protect against active TB. Elevated salivary IgA also highlights the potential importance of mucosal immunity. doi.org/10.1093/cei/uxaf001

🔬 New evidence suggests β-tubulin 5 (TBB5) is unlikely to be the pANCA target in primary sclerosing cholangitis (PSC), narrowing the search for the underlying autoantigen. 📖 doi.org/10.1093/cei/uxae053 #Immunology #Autoimmunity