@CDProteomics

Creative Proteomics has gradually developed into an integrated company that provides proteomics, metabolomics, glycomics, and bioinformatics services.

 Shirley, NY
creative-proteomics.com/
Joined September 2014
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Gut microbes may shape heart & kidney health years before symptoms. Microbial tyrosine/phenylalanine metabolites predicted future MI and death in 8,669 people (Nat Commun, 2026). doi.org/10.1038/s41467-026-6… #GutMicrobiome

A gut microbiome-kidney-heart axis predictive of future cardiovascular diseases

Nature Communications - The gut microbiome-kidney crosstalk has been previously linked with metabolic and kidney diseases. Here, the authors show that microbial amino acid metabolism interacts with...

nature.com
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A 4-week pomegranate intervention raised plasma propionate 162% (p=0.02). SCFA quantification (GC-MS) for this RCT was provided by Creative Proteomics. doi.org/10.3390/foods1301001… #GutMicrobiome #SCFA

Prospective Randomized, Double-Blind, Placebo-Controlled Study of a Standardized Oral Pomegranate...

Punica granatum L., commonly known as the pomegranate, is an abundant source of polyphenols, including hydrolyzable ellagitannins, ellagic acid, anthocyanins, and other bioactive phytochemicals shown...

mdpi.com
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Sequencing shows who's in the gut. Metabolomics shows what they're doing. SCFAs, bile acids, indoles, TMAO — untargeted discovery + targeted absolute quantification. metabolomics.creative-proteo… #Metabolomics
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Static levels show what's there. Turnover ratios show what's happening. 30+ neurotransmitters across 5 pathways by LC-MS/MS — incl. HVA/DA and 5-HIAA/5-HT flux ratios. metabolomics.creative-proteo… #Neuroscience

Neurotransmitter Analysis Panel | 30+ Dopamine, Serotonin, GABA, Glutamate LC-MS/MS Quantification...

Targeted LC-MS/MS quantification of 30+ neurotransmitters and metabolites across catecholamine, serotonin, GABA/glutamate, acetylcholine, and histamine pathways. Absolute quantification with stable...

metabolomics.creative-proteomics.com
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New in Nature Communications: a microfluidic electrochemical sensor captures breast cancer EVs via homotypic membrane interfaces. Blinded 141-subject study distinguished ER+/HER2+/triple-negative subtypes. doi.org/10.1038/s41467-026-6… #LiquidBiopsy #EVs

Homotypic membrane-powered electrochemical microfluidic analysis of extracellular vesicles for...

Nature Communications - The cancer cell membrane replicates the characteristic molecular profile of its parental cells. Here, authors construct a homotypic membrane-powered biomimetic interface for...

nature.com
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NK-cell EVs carry anti-tumor protein cargo. Cochran & Kornbluth profiled NK3.3 EVs and their effects on K562 leukemia cells, with proteomic analysis provided by Creative Proteomics. doi.org/10.3389/fcell.2021.6… #EVs #Proteomics

Frontiers | Extracellular Vesicles From the Human Natural Killer Cell Line NK3.3 Have Broad and...

Natural killer (NK) cells are critical mediators of immune function, responsible for rapid destruction of tumor cells. They kill primarily through the relea...

frontiersin.org
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Mitochondrial dysfunction is rarely a single-protein problem. End-to-end organelle proteomics: enrichment, LC-MS/MS quantification, PTM localization. creative-proteomics.com/subc… #MitochondrialProteomics
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EV counts tell you concentration. The cargo proteome tells you function. We isolate exosomes, confirm by NTA/TRPS, and profile proteins & PTMs by LC-MS/MS. creative-proteomics.com/subc… #ExosomeProteomics

Exosome Proteomics Services - Creative Proteomics Subcell

Creative Proteomics can provide you with a one-stop exosome proteomics CRO service, including exosome isolation, exosome identification, qualitative and quantitative analysis of exosome proteome,...

creative-proteomics.com
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A unified Prosit model predicts CID/HCD/UVPD/EID/ECD spectra, raising protein IDs by ~10% in FragPipe workflows. doi.org/10.1038/s41592-026-0…

Integration of alternative fragmentation techniques into standard LC-MS workflows using a single...

Nature Methods - An integrated mass spectrometry platform enabling automated collision-, electron- and photon-based fragmentation techniques is presented. A deep learning-based model trained to...

nature.com
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FASN proteolytic activation marks stress recovery in a 2024 Nature Metabolism study. The authors used untargeted metabolomics (LC-MS) from Creative Proteomics: doi.org/10.1038/s42255-023-0…
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Large-scale LC-MS/MS screens immune peptide candidates in one run and maps PTMs that shape recognition. Creative Proteomics: creative-proteomics.com/pept…

Immune Peptide Mass Spectrometry Analysis - Creative Proteomics Peptidomics

Creative Proteomics staff has many years of experience in large-scale immune peptide mass spectrometry analysis service. Our laboratories focus on science, compliance, and customer service.

creative-proteomics.com
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Direct HLA peptidomics captures the peptides cells actually present on HLA-I/II — including PTMs and cryptic epitopes prediction tools miss. Creative Proteomics: creative-proteomics.com/pept… #HLA
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AI is shifting proteomics from protein ID toward virtual-cell modeling. A new Nature Methods Perspective maps six areas of impact and the infrastructure still needed for reproducibility. doi.org/10.1038/s41592-026-0… #Proteomics #AI #MassSpectrometry
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Espino-Vázquez et al. mapped SPB/septal protein interactors in Neurospora crassa. For nano LC-MS/MS protein identification, the authors used Creative Proteomics. Published in Data in Brief (CC BY). DOI: 10.1016/j.dib.2023.109980 #Proteomics #CreativeProteomics
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No database? De novo protein sequencing builds the sequence from MS/MS spectra. Creative Proteomics uses 6 proteases + HCD/ETD w-ion evidence to resolve Leu/Ile. creative-proteomics.com/prot… #Proteomics #CreativeProteomics
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Top-down MS analyzes intact proteins, preserving co-occurring PTMs, terminal truncations, and sequence variants. Creative Proteomics covers 5 kDa to >150 kDa with Orbitrap/FT-ICR accuracy. creative-proteomics.com/prot… #Proteomics #MassSpectrometry #CreativeProteomics
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Full-DIA uses deep learning to recover missing diaPASEF spectra — substantial boost in proteins per single cell. Su, Xie et al., Genome Biology 2026. doi.org/10.1186/s13059-026-0… #SingleCellProteomics #diaPASEF

Full-DIA enables complete single-cell proteomics from diaPASEF using deep learning

Genome Biology - diaPASEF improves ion utilization and sensitivity by synchronizing quadrupole isolation with trapped ion mobility separation, making it suitable for single-cell proteomics. We...

link.springer.com
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Resting NK cell numbers depends on tryptophan catabolism via HIF-1α — Pelletier et al., EMBO Rep 2023. Untargeted + targeted metabolomics by Creative Proteomics. doi.org/10.15252/embr.202256… #Metabolomics #NKCell

Resting natural killer cell homeostasis relies on tryptophan/NAD+ metabolism and HIF‐1α

EMBO Reports - Natural killer (NK) cells are forced to cope with different oxygen environments even under resting conditions. The adaptation to low oxygen is regulated by oxygen‐sensitive...

link.springer.com
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Most cancer immunotherapy targets are MHC-bound peptides — invisible to standard proteomics. Immunopeptidome profiling reveals actual neoantigen presentation. creative-proteomics.com/ngpr… #Immunopeptidomics #Neoantigen
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DDA misses 20-30% of the proteome per run. 4D-DIA adds ion mobility — every peptide fragmented, no missing values. creative-proteomics.com/ngpr… #DIA #Proteomics
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