Cerebrovascular health enthusiast. BWH/Harvard/Broad Institute. My expressed opinions are solely my own.
Boston, MA
Joined September 2017
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Chris Anderson retweeted
Among the things hospitals teach you is a deep respect for disease. It is really hard to move the needle. We won't "cure all disease in 10 years". And there's a good change that medicine will still look much the same a decade from now.
https://xitter.cf/t.co/KWc3DRv7B7
Demis Hassabis: We can probably cure all diseases in the next 10 years
But investor Masayoshi Son said the same thing recently when $500 billion was invested in Project Stargate.
All we need is scale. More computing power, better algorithms.
Chris Anderson retweeted
#STROKE: In patients with acute ischemic stroke, admission NT-proBNP may predict the in-hospital development of atrial fibrillation detected after stroke (AFDAS), and a threshold of 505 pg/ml confers good discriminatory value. #AHAJournals ahajournals.org/doi/10.1161/…
ALT Graphic abstract in Hatab and Kneihsl et al.
Chris Anderson retweeted
Our study in @NephrologyJourn explores the interplay between #CKD and ischemic #stroke. Findings highlight the need for integrated care strategies to improve outcomes and reduce stroke risk in CKD patients. @leonardyeo1 @ClaraNgoh @CDAndersonMD
onlinelibrary.wiley.com/doi/…
Chris Anderson retweeted
Spatial proteomics in human carotid atherosclerotic plaques (N=118). A great weekend read❗️
👉subregions isolated with microdissection (lipid core, fibrous cap, tunica media)
👉mass-spec proteomics
👉proteome-defined subclusters across subregions
👉biological enrichment across subclusters
👉associations with instability features
👉predictions of unstable vs. stable plaque
👉correlations with plasma proteome
Thanks Tom. You’ve done so much for the field that I appreciate this tremendously.
New review article by Chris Anderson @CDAndersonMD on Genetics of intracerebral hemorrhage
journals.sagepub.com/doi/ful…
Chris Anderson retweeted
Another key resource for CNS genomic and drug target discovery research❗️
👉pQTLs for 6,361 CSF proteins (SomaScan aptamers)
👉N=3,506 samples
👉3,885 associations for 1,883 proteins
📜paper: nature.com/articles/s41588-0…
📊summ stats: wustl.app.box.com/s/3kms8fjz…
Chris Anderson retweeted
We made a lot of effort to put all summary statistics available. There are in four different places: 1) NIAGADS: dss.niagads.org/collections/…, 2) GWAS catalog, GCST90317902–GCST903193033, 3) Pheweb browser ontime.wustl.edu/, and 4) our website: neurogenomics.wustl.edu/open…
📰🔓Free early preprint version: researchsquare.com/article/r…
📊Browsable results: ontime.wustl.edu/
The data could be really valuable for downstream analyses of cerebrovascular, neurodegenerative, psychiatric, or other CNS traits.
Thanks @ccrugom and team🙏
You're never behind the genetic 8-ball. Making healthy lifestyle choices reduces your risk of age-related brain disease even if you have a genetic predilection. neurology.org/doi/10.1212/WN…. @BWHNeurology @MGHNeurology @CGM_MGH @broadinstitute
Chris Anderson retweeted
Comprehensive proteome-wide Mendelian randomization for 355 phenotypes in 3 ancestries
👉N=35,559 European, 1,871 African, 1,823 East Asian
👉SomaScan & Olink
👉extensive sensitivity analyses
📊Results browsable here: broad.io/protein_mr_atlas
📰Preprint: medrxiv.org/content/10.1101/…
Chris Anderson retweeted
I extend my deepest gratitude to my co-authors @rainermpg, @sdorodgar, @VineetRaghu2, @pnatarajanmd, @BellomoTiffany, and @CDAndersonMD for their invaluable contributions, and especially to my PI @MariosGeorgakis for making this possible and for his immense support
Chris Anderson retweeted
Many cool findings & a great resource for future research in atherosclerosis
📊GWAS summ stats to be posted on @GWASCatalog
Phenomenal work by star @Murad__Omarov⭐️
Great collaboration with @CDAndersonMD @rainermpg
@sdorodgar @VineetRaghu2 @pnatarajanmd @BellomoTiffany
Chris Anderson retweeted
🚨Postdoc Opening🚨
We're seeking a skilled scientist to lead research in multiomics❗️
Join our excellent interdisciplinary team👇in our efforts to tackle pressing challenges in cardiovascular disease
Lab: georgakis-lab.isd-muc.de
Position: findapostdoc.com/search/Job-…
Please RT!
Chris Anderson retweeted
- While the protective role of GFAT on CVD risk is mediated predominantly by common vascular risk factor modification (SBP, T2DM, LDL), residual mediatory effect may be exerted by adipose-specific factors, suggesting that targeting those may provide additional vascular benefit
Chris Anderson retweeted
The effects of a polygenic risk score for BMI on obesity and obesity-related morbidities are offset by a healthy lifestyle 🧬🍲🏃♀️
👉evidence of additive & multiplicative interaction
👉high PRS ⬆️ the effect of unhealthy lifestyle on obesity risk
sciencedirect.com/science/ar…
Honored to have you join the faculty Priya. Great things now and ahead.
#NewFaculty Dr. Priya Srikanth will join the Divisions of @BWHNeuroICU and Neurorecovery at @MassGenBrigham on July 1. Welcome, Priya!
Chris Anderson retweeted
GWAS of 2024 AI-derived (mainly imaging) human disease endophenotypes, including genetic correlations and Mendelian randomization associations with disease endpoints🧬
Summary stats to be made available upon publication
medrxiv.org/content/10.1101/…
Chris Anderson retweeted
Excited to share our study investigating the genetics of combined lipid patterns led by @tgillilandmd @jsdron! ahajournals.org/doi/10.1161/… @CircRes
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Chris Anderson retweeted
#HappeningNow BWH Neuroscience Day 2024 continues with poster presentations from across the department. 👩🔬 🧠
