@ButlerLabUCSB

Genome mining for unwinding iron binding. #BioInorganic #Chemistry, #Bioinformatics, #Biosynthesis Student run, opinions our own. IG: butlerlabucsb

 Santa Barbara, CA
labs.chem.ucsb.edu/butler/alison/
Joined April 2018
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Butler Lab @ UCSB retweeted
ACS Central Science@ACSCentSci24 Mar 2020
Grab ‘n go: siderophore-binding proteins provide pathogens a quick fix to satisfy their hunger for iron! Read #FirstRxns bit.ly/2UjsDKR by @ADGallo56 & Katherine Franz @FranzLabDuke on the research by the Wencewicz Lab @WashUChem bit.ly/3df202b
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Butler Lab @ UCSB retweeted
Jen Heemstra@jenheemstra24 Nov 2019
Bragging about huge numbers of hours worked each week misses two important truths: -time at work doesn’t necessarily equal productivity -there is no prize for suffering the most
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Butler Lab @ UCSB retweeted
UC Santa Barbara@ucsantabarbara9 Oct 2019
.@UCSB_chemistry’s graduate students recently discovered a technique to decipher siderophore's 3D structure. A better understanding this compound potentially means thwarting bacterial growth and treating certain illnesses. Findings appear in @PNASNews. ow.ly/ukWz50wGRxz

Seeing in Stereo

Chemists develop technique to predict siderophore structures from the genes that code for them

news.ucsb.edu
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"Mentoring: Reflections and Suggestions" -- Don't miss this editorial by Harry Gray, pioneer of #bioinorganic chemistry. Alison is a proud member of Gray Nation!
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We're lucky to have Rich in our department!
UC Santa Barbara@ucsantabarbara30 Sep 2019
Working with just his hand and a very hot flame, #UCSB's in-house glassblower Richard Bock shares his expertise on this niche profession. ow.ly/Iq2p50wtMyE

Master of Glass

UC Santa Barbara’s in-house glassblower combines scientific precision with ancient art

news.ucsb.edu
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Cool! Drosophila melanogaster has a nonribosomal peptide synthetase! pnas.org/node/850115.full
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#UCSB colleagues, sign ups are open for the 2019 Out List! Please consider coming out as member of the LGBTQIA community, or even as a supporter. Visibility matters! @ucsantabarbara @ucsb_rcsgd docs.google.com/forms/d/e/1F…

UCSB Out List 2019 Sign-up

Please enter information that you would like to share on the Out List, which will be published for public viewing at rcsgd.sa.ucsb.edu/out-list on October 11, 2019. All information you enter in this...

docs.google.com
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Butler Lab @ UCSB retweeted
Chemjobber@Chemjobber19 Sep 2019
When you finish a PhD in chemistry they take you in a special room and tell you that tenure-track professorships aren't real and all professors are just really old postdocs. I am posting this at great physical risk to myself and my family. xitter.cf/ButlerLabUCSB/status/1…
Butler Lab @ UCSB@ButlerLabUCSB19 Sep 2019
When you finish a PhD in chemistry they take you in a special room and tell you that the periodic table isn't real and all matter is just made of the elements earth, air, fire, and water. I am posting this at great physical risk to myself and my family.
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When you finish a PhD in chemistry they take you in a special room and tell you that the periodic table isn't real and all matter is just made of the elements earth, air, fire, and water. I am posting this at great physical risk to myself and my family.
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🚨 NEW PAPER ALERT 🚨 Our latest work on amino acid β-hydroxylation in #siderophores is online! pnas.org/content/early/2019/…

Genomic analysis of siderophore β-hydroxylases reveals divergent stereocontrol and expands the...

Genome mining of biosynthetic pathways streamlines discovery of secondary metabolites but can leave ambiguities in the predicted structures, which ...

pnas.org
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To confirm that we could actually use these trees to predict siderophore structures, Cliff, Jae, and Jean isolated four siderophores and stereochemically characterized the OHAsp residues. Each matched the subtype-based prediction! (10/11)
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To sum up, we can now predict the residue selectivity and stereospecificity of any siderophore β-hydroxylase. Although mechanistic questions remain, structures can now quickly be predicted just by looking at the gene cluster, or better yet, by using the pHMMs provided. (11/11)
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