@BurnettLabUSU

Professor of Neuroscience and Cell and Molecular Biology. Uniformed Services University Cellular Proteolysis and Neurodegeneration Lab

 Bethesda, MD
burnettlab.com/
Joined April 2016
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  • Following252
  • Followers216
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Excited to share our recent collaborative effort led by former graduate student @GKhayrullina and a star-studded team including @KotharyLab and @modeguise. Comments welcomed! Survival motor neuron protein deficiency alters microglia reactivity onlinelibrary.wiley.com/doi/…

Survival motor neuron protein deficiency alters microglia reactivity

SMA microglia adopt a reactive morphology. Complement gene expression, migration velocity and phagocytosis are increased in SMA microglia. SMA microglia release factors that alter the morphology...

onlinelibrary.wiley.com
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Microglia-astrocyte crosstalk in the amyloid plaque niche of an Alzheimer’s disease mouse model, as revealed by spatial transcriptomics sciencedirect.com/science/ar…
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I am happy to share our latest work on the discovery and studies of the neuronal membrane proteasome in somatosensory neurons is now online in @CellPressNews at @CellReports cell.com/cell-reports/fullte…

The nociceptive activity of peripheral sensory neurons is modulated by the neuronal membrane...

Proteasomes are critical for sensory neuron function. Villalón Landeros et al. uncover a specialized proteasome in somatosensory neurons called the neuronal membrane proteasome (NMP). The NMP...

cell.com
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BurnettLab retweeted
M W@Michael_E_Ward_6 Apr 2024
TDP43 proteinopathy exhibits disease, tissue, and context-specific cryptic splicing signatures | bioRxiv biorxiv.org/content/10.1101/…

TDP43 proteinopathy exhibits disease, tissue, and context-specific cryptic splicing signatures

Mislocalization of the nuclear protein TAR DNA-binding protein 43 (TDP43) is a hallmark of ALS and FTD which leads to de-repression and inclusion of cryptic exons. These cryptic exons represent...

biorxiv.org
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Generation of Human Induced Pluripotent Stem Cell (hiPSC)-Derived Astrocytes for Amyotrophic Lateral Sclerosis and Other Neurodegenerative Disease Studies bio-protocol.org/en/bpdetail…
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Just updated: Download our massive database of postdoctoral fellowships (316!) For each fellowship, we provide a description, link, $ amount, eligibility criteria, and deadline. download this database here: research.jhu.edu/rdt/funding…
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New @CellReports paper: Efficient exon skipping by base-editor-mediated abrogation of exonic splicing enhancers. tinyurl.com/4y6dyu4s
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Postdoctoral Fellow, Stevens Lab | ALZFORUM Stevens lab is looking for a talented postdoc to lead a project to understand how aging and genetic risk impact cell specific vulnerability and resilience using human iPSC-derived microglia & in vivo models alzforum.org/jobs/postdoctor…
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New @NatureComms paper: Reprogramming of cis-regulatory networks during skeletal muscle atrophy in male mice. tinyurl.com/mrxrcexw
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#myotwitter Muscle develops as multinucleated cells and can add more nuclei to adapt to stimuli. What are these newly fused myonuclei doing? You be the judge by checking out the lab's latest work by Chengyi Sun and @swoboda_casey @CincyKidsHeart biorxiv.org/content/10.1101/…

Lineage tracing of newly accrued nuclei in skeletal myofibers uncovers distinct transcripts and...

Multinucleated skeletal muscle cells have an obligatory need to acquire additional nuclei through fusion with activated skeletal muscle stem cells when responding to both developmental and adaptive...

biorxiv.org
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BurnettLab retweeted
ShorterLab@ShorterLab2 Aug 2023
Timing matters: A protective role of astrocyte reactivity in neurodegeneration: cell.com/neuron/fulltext/S08…

Timing matters: A protective role of astrocyte reactivity in neurodegeneration

Sheehan and Nadarajah et al. identified that Bmal1 loss from astrocytes induces the expression of BAG3, a macroautophagy chaperone enriched in Alzheimer’s disease patients and in disease-associated...

cell.com
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The Millay lab @CincyChildrens @CincyKidsHeart is delighted to participate in this consortium that aims to discover and innovate new therapies for genetic muscle diseases
MAGIC@MAGIC_horizon11 Jul 2023
We are thrilled to announce the launch of the groundbreaking MAGIC project. This ambitious 4-year initiative aims to transform the treatment landscape for muscular dystrophies. → Full press release: magic-horizon.eu/ #innnovation #research #neuromuscular #genetherapy
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BurnettLab retweeted
M W@Michael_E_Ward_28 Jun 2023
sciencedirect.com/science/ar…
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Our @USUhealthsci grad students are publishing research, winning awards and fellowships, and advancing military medicine and public health. Learn more - attend our open house on June 21. medschool.usuhs.edu/academic…
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I’m biased of course, but a great place to teach and, even better, to always be learning! @USUhealthsci @WRBethesda
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Are you looking for a Postdoctoral position? We have an NIH funded position just for you!! See: lnkd.in/eHja8rdd

LinkedIn

This link will take you to a page that’s not on LinkedIn

lnkd.in
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BurnettLab retweeted
Sumner Lab@SumnerLab3 Apr 2023
Check out our new paper in Acta Neuropathologica Communications, co-authored by Lingling Kong and Cera Hassinan! Congrats to them both! rdcu.be/c83Jx
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DNA sensing via the cGAS/STING pathway regulates immunoproteasome function and MHC class I antigen presentation to promote T-cell activation - with implications for the pathology of idiopathic pulmonary fibrosis @MeinersLab @FZBorstel embopress.org/doi/10.15252/e…
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BurnettLab retweeted
Sumner Lab@SumnerLab12 Mar 2023
Submissions are open for the new research collection, “Sensory Systems of Aquatic Animals” @FrontPhysiol, edited by Laure Bonnaud-Ponticelli, Anna Di Cosmo, and Jeremy Sullivan (@SumnerLab). For further details see: frontiersin.org/research-top…
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Come join Uniformed Services University at our Brain Awareness Day event on Saturday, March 18th from 10 a.m. to 2p.m. @USUhealthsci will help participants will learn about the structural and functional components of a neuron through an interactive build-a-neuron station.
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Pleased to announce that the PDF file of our article on DG9-conjugated #morpholino and rescue in #SMA mice is now available @JCI_insight. This promising delivery strategy reached the CNS via an SC administration. insight.jci.org/articles/vie… @UAlberta_FoMD supported by @WCHRIUofA
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