Exploring and Exploiting the Functional Capabilities of Nucleic Acids
Joined May 2014
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BurkeLab retweeted
BREAKING NEWS
The 2023 #NobelPrize in Physiology or Medicine has been awarded to Katalin Karikó and Drew Weissman for their discoveries concerning nucleoside base modifications that enabled the development of effective mRNA vaccines against COVID-19.
BurkeLab retweeted
If you’re into DNA, go to minute 13-14. This is so cool!
we made a DNA replica of a NERF blaster with @MarkRober! currently the #1 trending video on @YouTube with more than 3M views in less than 12h 🤯check it out! 🧬youtu.be/9c2NqlUWZfo?si=h0dB…
Almost all our pubs are collaborations...
We just submitted a great piece yesterday. Collaborator wrote to me:
"It's a productive collaboration between your lab and mine. Neither lab alone would have achieved what we got."
... and that's why. 😃
Structural mechanisms of HIV-1 capsid lattice stabilization
Oooff! This one tested our limits (7 Xray structs, molec-dynamics simulations, cryoEM, timeresolved imaging, biophys/biochem to elucidate how mutations enhance/reduce HIV core stability, thus impairing infectivity & how 2ndsite mutations rescue infection. nature.com/articles/s41467-0…
Keeping my distance from 'X' these days. Hence the silence.
What alternative social media platforms are ppl using these days?
What makes it 'better' (apart from absence of the distasteful parts of 'X')?
BurkeLab retweeted
#SAMURI is a new #ribozyme for RNA-catalyzed labeling of RNA. It uses a new cell-permeable SAM analogue and generates a novel propargylated nucleotide in RNA. Check out the full story doi.org/10.1038/s41557-023-0…
rclcu.be/dlcxN
New #ribozyme #SAMURI uses a new synthetic cofactor to make #RNA in living cells accessible for #ClickChemistry: Congrats on this publication @NatureChemistry to @HoebartnerLab @JoergLab @Helmholtz_HIRI! ➡️ go.uniwue.de/ribozyme-samuri
ALT SAMURI is a new ribozyme that attaches a targeted modification to cellular RNA for click chemistry. (Picture: Working group Claudia Höbartner / University of Würzburg)
BurkeLab retweeted
Happy pi approximation day!
Today's date, 22 July, can also be written as the fraction 22/7, which is equal to 3.14285714, an approximation of π, correct to two decimal places.
ALT A golden brown apple pie with the 'pi' symbol cut into it.
BurkeLab retweeted
A Biochemist and a Geologist walk into a bar and try to solve the origins of life problem.
Bartender to them: how on earth did life begin?
Them: Exactly!
BurkeLab retweeted
Very cool work. Reminds me of a paper from @ProfTomEllis lab that I believe was the first to use a fluorescent aptamer + protein (doi.org/10.1021/sb400089c) and inspired some of my own work with @BurkeLabRNA doi.org/10.1021/acssynbio.7b….
Great idea! @eternagame teaches humility, since designs can easily get tangled up in alternate folds!
Excited to share how I use @eternagame to teach students about #RNA folding & function in my @NSF CAREER funded, CURE-style Chemical Biology lab course!
This was a fun test for detecting real/fake news. I scored 18/20 on MIST, better than 81% of the US population.
Thanks @JosephYesselman !
What is #YourMIST? 🧐 yourmist.streamlit.app #misinformation #fakenews
BurkeLab retweeted
Expanding the scope of RNA-catalyzed reactions @Uni_WUE. This work ow.ly/qXAX50OXTr3 #AngewandteVIPs shows how to install a formyl group in RNA using the methyltransferase ribozyme MTR1. exciting applications for site-specific fluorogenic labeling of RNA and more.
Ribozyme-Catalyzed Late-Stage Functionalization and Fluorogenic Labeling of RNA (Claudia Hoebartner and co-workers) @Uni_WUE @HoebartnerLab #AngewandteVIP #openaccess thanks to #projektDEAL ow.ly/qXAX50OXTr3
Diagonal bike lane.
There’s an innovation I could do without.
I’m a proud SF cyclist. Always will be.
But this new diagonal bike lane on 23rd & Valencia is a failure and dangerous.
I was recording because I have a genuine question for @sfmta: what do you expect to happen when the light turns green?
‘Organometallic Pillarplex’
In February it was a preprint, now our collaborative work with @HannonGroup is out - and even published in JACS! Thanks to all the collaborators who contributed to this marvelous work!
pubs.acs.org/doi/10.1021/jac…
