@Bryson_Choy

PhD @UCSF with @yimmieg | Prev @USC

 San Francisco, CA
Joined April 2018
  • Tweets27
  • Following172
  • Followers207
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Bryson Choy retweeted
Jimmie Ye@yimmieg24 Oct 2024
1/🧵Excited to re-introduce Memento in (cell.com/cell/fulltext/S0092…), a scalable method for differential analysis of scRNA-seq data. It provides first-in-class performance in statistical power and calibration for comparing differences in mean, variability, and gene correlation.👇

Method of moments framework for differential expression analysis of single-cell RNA sequencing data

Memento implements a statistical model and a fast resampling procedure to estimate and compare the mean, variability, and correlation of gene expression, allowing for the study of transcription in a...

cell.com
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Bryson Choy retweeted
Jimmie Ye@yimmieg11 Aug 2023
New joint work with @vntranos using ESM, an LLM trained by Meta to predict the effect of all coding mutations in the genome: nature.com/articles/s41588-0…. Full tweetorial coming from @BrandesNadav. Will just reflect briefly. 1/n.

Genome-wide prediction of disease variant effects with a deep protein language model

Nature Genetics - A modified framework leveraging a protein language model (ESM1b) is used to predict all possible 450 million missense variant effects in the human genome and shows potential for...

nature.com
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🎉 Huge Congrats to Katie Pollard! 🎉 bit.ly/3SdoqEi
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If you are interested in developing computational approaches to understand 3D genome organization, get in touch!
jobRxiv
@jobRxiv10 Jul 2022
Computational 3D Genome Biology at USC with @gfudenberg University of Southern California, Department of Quantitative and Computational Biology, Los Angeles, USA jobrxiv.org/job/university-o… #ScienceJobs

Computational 3D Genome Biology at USC

Post a job in 3min, or find thousands of job offers like this one at jobRxiv!

jobrxiv.org
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Bryson Choy retweeted
USC
@USC20 May 2022
USC University Professor Emeritus Michael Waterman is the ' father of quantitative and computational biology'. Learn more about how Waterman pioneered this research and movement! #ComputationalBiology #ComputerResearch news.usc.edu/199827/human-ge…
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Congratulations, Class of 2022! You did it! Wishing you the best on your next adventure! #USCGrad #FightOn #USCDornsifeGrad #USCViterbiGrad #KSOMGrad #2022Trojan #USCMichelsonCenter ✌️🎓
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Bryson Choy retweeted
nature
@Nature18 Dec 2021
A virtual drug-screening approach to conquer huge chemical libraries nature.com/articles/d41586-0…
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Bryson Choy retweeted
Seva Katritch@sevakat115 Dec 2021
Fitting molecular puzzle piece by piece by V-SYNTHES. Our new fast Giga-scale virtual screening is out in Nature. Kudos to V-SYNTHES developers @ASadybekov and @SadybekovArman, and folks at @zenbrainest and Makriyannis labs, @Chem_space and @EnamineLtd nature.com/articles/s41586-0…
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What drives organization of RNA, DNA, and proteins in the nucleus? In our new paper out @CellCellPress, we show that non-coding RNAs play a central role through a unique RNA-based mechanism. authors.elsevier.com/c/1e132…
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