Bioinorganic chemistry lab at Montana State University. Totally radical. Also, we ski. And fish. And hike. And camp. Lab-run account.
Joined January 2019
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Broderick Lab retweeted
The [4Fe-4S] Cluster of HydF Is Essential for [FeFe]-Hydrogenase Maturation | Journal of the American Chemical Society pubs.acs.org/doi/10.1021/jac…
Broderick Lab retweeted
Fantastic research group camping outing last weekend: two nights of a northern lights show, a beautiful float and card games. Perfect weather only a few days after an 8” snow storm. @BroderickLabFeS
Broderick Lab retweeted
Check out our #potw! Thanks Alina for presenting this cool work about a radical SAM epimerase by the Broderick lab. Read to learn how a conserved Cys to Ser mutation helped trap and characterize the α-C • intermediate of OspA using rapid quench & EPR
pubs.acs.org/doi/10.1021/jac…
Broderick Lab retweeted
Congrats to @AnnaVagstad bringing this amazing story to the finish line! Thank you to everyone involved from @BroderickLabFeS for the fantastic collaboration! If you are interested in the enzymatic mechanism of peptide epimerization by rSAM, make sure to read it.👇
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Detection of the α-Carbon Radical Intermediate Formed by OspD: Mechanistic Insights into Radical S-Adenosyl-l-methionine Peptide Epimerization |Journal of the American Chemical Society @montanastate #Radical #Detection #OspD #SAM #Peptide #Epimerization pubs.acs.org/doi/10.1021/jac…
Broderick Lab retweeted
Kudos to grad student Will Walls @BroderickLabFeS on outstanding work that led to his first @J_A_C_S paper! Congrats also to undergrad Tyler Delridge, Will Broderick, and collaborators @AnnaVagstad and @piel_lab. Radical epimerization in RiPP maturation.
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Detection of the α-Carbon Radical Intermediate Formed by OspD: Mechanistic Insights into Radical S-Adenosyl-l-methionine Peptide Epimerization |Journal of the American Chemical Society @montanastate #Radical #Detection #OspD #SAM #Peptide #Epimerization pubs.acs.org/doi/10.1021/jac…
Broderick Lab retweeted
We showed that upon reductive SAM cleavage, the 5’-dAdo radical moves *towards* the [4Fe4S] cluster, on its way to forming the omega organometallic intermediate. The once elusive radical, triangulated! @BroderickLabFeS @MartinMosqueraT
ENDOR Spectroscopy Reveals 5′-Deoxyadenosyl Radical in a Radical SAM Enzyme Active Site is Chaperoned by Interaction with Methionine-Bound [4Fe–4S]2+ Cluster JACS @montanastate @NUChemistry @Northwestern #ENDOR #Adenosyl #Radical #Methionine #Chaperone pubs.acs.org/doi/10.1021/jac…
Broderick Lab retweeted
ENDOR Spectroscopy Reveals 5′-Deoxyadenosyl Radical in a Radical SAM Enzyme Active Site is Chaperoned by Interaction with Methionine-Bound [4Fe–4S]2+ Cluster JACS @montanastate @NUChemistry @Northwestern #ENDOR #Adenosyl #Radical #Methionine #Chaperone pubs.acs.org/doi/10.1021/jac…
Broderick Lab retweeted
New in ChemComm:
@joanbroderick and colleagues report the semisynthetic maturation of [FeFe]-hydrogenase, revealing new insights into the nature of H-cluster biosynthesis.
@BroderickLabFeS
bit.ly/46W7lHy
Broderick Lab retweeted
Computational Description of Alkylated Iron–Sulfur Organometallic Clusters | Journal of the American Chemical Society @montanastate @msuchembiochem @ResearchNU @NorthwesternU @NUChemistry #Computational #Alkylated #IronSulfur #Organometallic #Clusters pubs.acs.org/doi/10.1021/jac…
A new mini review from our lab focusing on in vitro [FeFe]-hydrogenase maturation. Interesting chemistry & biochemistry with still so much to learn!
[FeFe]-Hydrogenase In Vitro Maturation (Broderick) @BroderickLabFeS @joanbroderick onlinelibrary.wiley.com/doi/…
Happy to share our most recent review on radical SAM enzymes:
FEBS Press febs.onlinelibrary.wiley.com…
Broderick Lab retweeted
We have a fantastic department with so many amazing young faculty - come work in this stimulating and collegial community! Bozeman is not bad either!
Organic chemistry assistant professor opening at Montana State:
chemistryjobs.acs.org/job/37…
Broderick Lab retweeted
.@joanbroderick & gang review [FeFe]-hydrogenase in vitro maturation. Out now with @angew_chem! doi.org/10.1002/anie.2022120…
Congrats to Katherine on graduating today with a B.S. in Chemistry/Biochemistry. She has been an awesome research student and lab mate and we will miss her!
Broderick Lab retweeted
Dana Longcope of @montanastate has been elected to the National Academy of Sciences for research on the nature of solar magnetism, and magnetic topology. #NAS159
Read more: ow.ly/n3sV50IYEuX #physics
Broderick Lab retweeted
Congratulations to Joan B. Broderick of @montanastate who joins the National Academy of Sciences for her outstanding contributions to biochemistry. #NAS159
Read more: ow.ly/jMFs50IYzho #biochemistry
Congratulations to Joan on election to the American Academy of Arts & Sciences! @americanacad @joanbroderick @msuchembiochem @montanastate
Congratulations to the newly elected members of the American Academy! Today we are honored to welcome 261 exceptional individuals - including artists, scholars, scientists, and leaders in the public, non-profit, and private sectors - into the Academy.
amacad.org/news/2022-member-…
Broderick Lab retweeted
A grad student interested in teaching positions? A post-doc looking to diversify? The @BUChemistry PAL program has been a successful way for training toward a PUI position! We are looking for 3 new PALs. You'll have a research and a teaching mentor! academicjobsonline.org/ajo/j…
Broderick Lab retweeted
[FeFe]-Hydrogenase: Defined Lysate-Free Maturation Reveals a Key Role for Lipoyl-H-Protein in DTMA Ligand Biosynthesis (Broderick) @BroderickLabFeS onlinelibrary.wiley.com/doi/…
