Longevity hacker. Longevity solutions client. DunedinPace under 1, but not by enough. Donations to @LongevityEVF @impetusgrants @dogaginginst
USA
Joined July 2026
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Brain Vat retweeted
Every compound the ITP has ever tested. Doses, sex-specific results, starting ages, primary sources. Updated with 20 new entries:
docs.google.com/spreadsheets…
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Source: NIA Interventions Testing Program, March 2026 results.
The ITP has been running since 2004 at three independent sites (Jackson Laboratory, University of Michigan, UT Health San Antonio). All compounds tested in genetically heterogeneous UM-HET3 mice (both sexes). This batch: 11 compounds, 0 positive results.
Rapamycin remains the single most consistent lifespan extender in ITP history.
Rapamycin + acarbose holds the record (34% male, 28% female median lifespan increase).
Of 65+ compounds tested over 20 years, only a handful worked; all are cheap, off-patent drugs.
ITP negative results published in @GeroScienceAGE: link.springer.com/article/10…
Brain Vat retweeted
11 compounds tested across three independent sites in 30,000+ mice. Zero extended lifespan.
The @NIHAging's Interventions Testing Program just released its March 2026 results. I've updated the ITP master spreadsheet with 20 new entries since my deep dive last week.
Alpha-ketoglutarate (longevity community favorite) didn't work. Astaxanthin (in every health food store) didn't work.
Meclizine, mitoglitazone, mifepristone, methotrexate, atorvastatin+telmisartan combo: all zero.
Pioglitazone shortened female lifespan by 6.2%.
After 20 years and 80+ compound tests, the pattern holds. The drugs that actually extend lifespan (rapamycin, acarbose, canagliflozin, 17-alpha estradiol) are cheap generics. Every single one.
If your stack costs $200/month, check the spreadsheet. The ITP has tested most of what's in it.
Brain Vat retweeted
Reanalysis of data from the Interventions Testing Program using an alternative statistical test identifies additional life‑extending compounds.
lifespan.io/news/a-re-analys…
by @DrangowskaWay
#aging #lifespan #longevity #rejuvenation #ITP #InterventionsTestingProgram #metformin
Brain Vat retweeted
ARPA-H's AIR program will mobilize our nation’s most advanced technological and clinical expertise to revolutionize robotic surgery, helping millions of Americans by filling critical gaps in surgical care and stroke treatment.
Our new AIR program aims to benefit the millions of Americans who will suffer a stroke in their lifetime – and where timely clot removal matters for quality of life.
Learn about our autonomous robotic surgery program targeting stroke treatment. arpa-h.gov/explore-funding/p…
Brain Vat retweeted
Recently, I joined @SecretaryKennedy in launching a first-of-its-kind initiative to measure and remove microplastics.
@ARPA_H’s $144 million STOMP program will help us understand how microplastics impact our health and guide affordable treatments solutions for all Americans.
Brain Vat retweeted
Thank you, @SecKennedy, for this Extraordinary Achievement Award.
I am proud to accept it on behalf of the @ARPA_H team and our work to accelerate breakthroughs for patients.
That urgency is at the heart of our mission and the Make America Healthy Again agenda.
Brain Vat retweeted
Grateful to @FLOTUS and @POTUS for leading the Women’s Health Executive Order and creating the White House Women’s Health Task Force.
I’m proud to work alongside fellow members to move women’s health faster and turn this momentum into breakthroughs.
President Trump and the First Lady Sign an Executive Order xitter.cf/i/broadcasts/1vJpPNvEA…
Brain Vat retweeted
Tinnitus symptoms can include hearing ringing or buzzing in one or both ears. There are many possible causes, such as a head or neck injury that can damage areas of the brain that process sound. Learn more: go.nih.gov/PwBfn0H #BrainAwarenessWeek #BrainWeek
ALT Man holding ear while wincing.
Brain Vat retweeted
During #MarchMadness, cheer on your team and protect your ears from noise-induced hearing loss. Hearing protectors help lower the intensity of sound that enters your ears. Learn more: go.nih.gov/JiVoXvg @MarchMadnessMBB @MarchMadnessWBB
ALT pre-molded, high fidelity earplugs
Brain Vat retweeted
The pharmaceutical industry has largely ignored peptides because they're difficult to patent and don't fit the traditional drug model.
But that's changing. The peptide therapeutics market has grown to over $42 billion, and it's projected to more than double by 2033. (Straits Research 2024; Market. us 2024)
The success of GLP-1 agonists like semaglutide has proven what's possible when we take peptides seriously as medicine.
And here's what most people don't know: David Sinclair recently stated that GLP-1 receptor agonists "are looking like longevity drugs." His research shows these peptides work through SIRT1, the same sirtuin pathway his lab has studied for decades. In a 2024 review co-authored with MIT's Leonard Guarente, Sinclair identified GLP-1 agonists as one of eight compounds with proven anti-aging effects in humans. (Guarente, Sinclair & Kroemer, Cell Metabolism 2024)
We went from dismissing peptides to watching semaglutide become a $13.89 billion drug that reduces cardiovascular death, reverses fatty liver disease, and may even protect against Alzheimer's.
The molecules pharma once ignored are becoming the future of medicine.
Brain Vat retweeted
The whole peptide game changes when they are certified USA made and are verified by agreed upon standards. The question is, which peptides will land in that class besides GLPs?
Brain Vat retweeted
Source: jamanetwork.com/journals/jam…
Brain Vat retweeted
.@SecKennedy on peptides: "The Trump Administration believes in freedom of choice... Americans ought to be able to get them, but they should be able to get ones where they know what the purity is and they know that they have come from a safe environment."
Brain Vat retweeted
映像から見えない筋肉の動きを推定する「SOMA v2」公開🩻
🔹RGB映像から皮膚の下にある筋肉の変形を推定
🔹SKIM v2でデータセットや骨格リグを改善
🔹従来のLBSと比べマーカー誤差58%減。筋肉と皮膚の衝突率は0.06%と報告
開発者：Eduardo Alvarado氏ら
コード・データ公開中。
情報元はリプ欄。
Brain Vat retweeted
The encouraging detail is that 82.2% of patients receiving the vaccine plus Keytruda were alive without melanoma returning at two years, versus 70% on Keytruda alone. That’s roughly 12 more people in every 100. I’m keen to see how that gap holds up with longer follow up.
