@BobtheSpindle

My name is Bob, and I am a mitotic spindle. I have never mis-segregated a chromosome. I speak for spindles everywhere.

 Within cells, here and there
Joined April 2023
  • Tweets109
  • Following97
  • Followers124
7Media
A Saudi football club is offering Mbappe a $776 million salary for ONE year. If that one-year salary money was given to me, I would put it in a bank, collect 5% interest ($40 million per year)...and then use that to fund the research programs of 100 mitosis labs in full FOREVER
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People with mitotic spindle pics as their twitter handle get funded first
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Bob the Mitotic Spindle retweeted
Elif Nur Firat-Karalar@CytoLabKoc27 Jun 2023
Please RT! The abstract submission deadline for the EMBO Centrosome in Development, Disease and Evolution meeting is 1st of July. Below is the link for abstract submissions and registrations. meetings.embo.org/event/23-c…

Centrosomes in development, disease and evolution

Centrosomes are microtubule-organizing centers (MTOC) that function in conserved and diverse cellular and organismal processes. Their deregulation causes various human diseases including cancer and d…

meetings.embo.org
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MCAK is a good little kinesin that helps me segregate chromosomes accurately. It seems almost unconscionable to want to intentionally inhibit this protein...yet, this paper makes a good argument for it!
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Need a chromosome moved a mile away? I can do it. Just give me a thousand years or so.
Bob the Mitotic Spindle@BobtheSpindle23 Jun 2023
Well, maybe its because I'm cautious, but I only move chromosomes at 0.000000111 mph during anaphase. Slow and steady wins the race.
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Well, maybe its because I'm cautious, but I only move chromosomes at 0.000000111 mph during anaphase. Slow and steady wins the race.
Niko McCarty.
@NikoMcCarty22 Jun 2023
Cells are very fast and crowded places. A molecule of glucose flies through a cell at 250 mph. A protein tumbles 60 million times per minute. These numbers seem made up. How did we figure this stuff out?
Acknowledgement: Martina Maritan, Ludovic Autin, David S. Goodsell, Scripps Research and RCSB Protein Data Bank. doi: 10.2210/rcsb_pdb/goodsell-gallery-040

ALT Acknowledgement: Martina Maritan, Ludovic Autin, David S. Goodsell, Scripps Research and RCSB Protein Data Bank. doi: 10.2210/rcsb_pdb/goodsell-gallery-040

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A conference all about me! ☺️ FWIW, I'm much better at executing mitosis than the poor spindle in this cartoon, which doesn't appear to have formed a single amphitelic attachment yet. Rookie.
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How data is presented in Boston research labs
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Just be honest @StearnsLab, you're scolding this poor plant for not having centrosomes.
Tim Stearns@StearnsLab13 Jun 2023
In La Jolla, thinking of scale and morphology.
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NPG should just start a new journal: Nature Micronuclei Two new papers show that chromosomes in MN are epigenetically reprogrammed, and that the changes are heritable nature.com/articles/s41586-0…

Epigenetic dysregulation from chromosomal transit in micronuclei

Nature - Missegregated chromosomes that are sequestrated in micronuclei are subject to changes in histone modifications leading to abnormalities in chromatin accessibility that remain long after...

nature.com
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nature.com/articles/s41586-0…

Heritable transcriptional defects from aberrations of nuclear architecture

Nature - Micronuclei, which are common features of nuclei in cancer cells, can generate heritable sources of transcriptional suppression, a finding that establishes an inherent relationship between...

nature.com
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Bob the Mitotic Spindle retweeted
Oliveira Lab@CHR_lab1 Jun 2023
Please RT: *JOB ALERT* We have an open post-doc position in our lab to study sister chromatid resolution during mitosis. PM for more info. chromosomedynamicslab.com/po…
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TIM STEARNS!! HOW DARE YOU
Tim Stearns@StearnsLab31 May 2023
The most beautiful and impressive machine nature has built. The latest from @alanbrownhms and colleagues on the axoneme of motile cilia. nature.com/articles/s41586-0…
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MDM2, cyclin B, truncated cdc20....so many mitotic timers I'm getting anxiety! biorxiv.org/content/10.1101/…

MDM2 acts as a timer reporting the length of mitosis

Delays in mitosis trigger a p53-dependent arrest in G1 of the following cell cycle, enabling cells to react to changes promoting aneuploidy [[1][1]-[10][2]]. How delays in mitosis are sensed and...

biorxiv.org
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"Mitotic catastrophe" People use the term in so many different ways. The only consistent thing about the term "mitotic castastrophe" is that it hurts my feelings every time I see it.
Dmitri Petrov@PetrovADmitri25 May 2023
A question for the hivemind. Which terms in biology (especially evolution, ecology, genetics) do you find slippery and confusing? Where you often feel that people use the same word but mean different things? E.g for me it’s fitness, epigenetics, niche, gene. Others?
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I assume this is about mitosis in osteoprogenitor cells.
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😨On behalf of all microscopic structures everywhere, please accept our condolences. And to the microscopes, please get well soon
Kay M Tye PhD
@kaymtye17 May 2023
In case you like horror and are the type that just cant stop watching: (No this is not a GIF from the internet, this is real footage from my lab yesterday and our most active 2P in a room holding two 2Ps). Courtesy of 1st responder @science_is_hard
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Sorry England, I only acknowledge one king. Randy King. Because he studies mitosis and doesn't wear funny clothes. @rwkhms
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Walther Flemming, the minute he laid eyes on a mitotic spindle for the first time
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Lateral versus end-on KT-MT attachment
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