@BlueBrainPjt

The aim of the EPFL Blue Brain Project is to build biologically detailed digital reconstructions and simulations of the mouse brain.

epfl.ch/research/domains/bluebrain/
Joined September 2012
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This Dec, @BlueBrainPjt celebrates the completion of its 20-yr mission to establish #simulation #neuroscience as a complementary approach. Thank you for your support!🎉 Our models, data, algorithms, and platform stay open at portal.bluebrain.epfl.ch/
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📢Happy to share our latest #connectomics work published in @iScience_CP. We explore the effect of the higher order structure on neuronal function in our biologically detailed model & @AllenInstitute's MICrONS EM data set. cell.com/iscience/fulltext/S… #simulation #neuroscience
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Simplified models of #neural #networks reveal the need of a tradeoff in brain coding: more redundancy in neuronal activity enhances fault tolerance but reduces memory capacity. The severity of the tradeoff is mediated by the level of neuronal variability.
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The diverse architecture of biological #neural #networks helps regulate the tradeoff, letting subpopulations optimize for different goals. We develop a metric based on simplicial complexes that captures connectivity complexity & distinguishes between subpopulations.
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Two decades of groundbreaking work at @BlueBrainPjt !As the project concludes, dive into a digest of key scientific milestones and notable publications. epfl.ch/research/domains/blu… Want to try #simulation #neuroscience ? Check our platform & its developments: openbluebrain.com
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📢 Publication Alert! Our latest #connectomics work has been published in @netneurosci ! This methods paper presents a novel Python framework for rapid #connectome manipulations of detailed, biologically realistic network models in SONATA format 👉doi.org/10.1162/netn_a_00429
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We modified a detailed rat SSCx model in two ways 1.Increasing VIP+ interneuron connectivity based on @AllenInstitute MICrONS data 2.Removing higher-order E-to-E connectivity features. Simulations showed specific activity changes from these manipulations. doi.org/10.7554/eLife.99693.…
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Interested in using our framework? Check out our code repositories here: github.com/BlueBrain/connect… and advanced use case examples here: github.com/BlueBrain/sscx-co…

GitHub - BlueBrain/connectome-manipulator: A connectome manipulation framework for SONATA circuits

A connectome manipulation framework for SONATA circuits - BlueBrain/connectome-manipulator

github.com
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📢Preprint alert! Discover the 1st comprehensive mouse #brain #atlas using @AllenInstitute 's CCFv 3 ! Precisely aligned Nissl-based ref. data enables accurate, automated mapping of histological slices & volumes. A game-changer for brain research 🔬 📰biorxiv.org/content/10.1101/…
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We've added spinal cord layers, barrel columns, extended olfactory bulb & granular/molecular layers in the cerebellum creating an enhanced cell atlas. Every cell in the mouse brain is now mapped by location, region, and type, unlocking new insights! 📰biorxiv.org/content/10.1101/…
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📌 From this data, properties such as neuron soma and morphology can be derived, paving the way for increasingly accurate #simulation #neuroscience models. Let us know what it will change for you! Get all the details here biorxiv.org/content/10.1101/…

An extended and improved CCFv3 annotation and Nissl atlas of the entire mouse brain

Brain atlases are essential for quantifying cellular composition in mouse brain regions. The Allen Institute’s Common Coordinate Framework version 3 (CCFv3) is widely used, delineating over 600...

biorxiv.org
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📢Publication Alert! Our latest #connectomics work is out in Cerebral Cortex. We have analyzed one of our favorite open datasets: @AllenInstitute 's MICrONS cortical mm^3. In this EM dataset we found new rules for neuronal connectivity & describe them doi.org/10.1093/cercor/bhae4…
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We found the higher-order structure of excitation contains specific motifs that form a backbone of connectivity in a fan-out structure. Inhibitory connectivity is structured by this, providing specific competition between the motifs. Disinhibition in turn targets these neurons
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Our SSCx model (linktr.ee/BlueBrainPjt) provided a valuable null model to compare findings against: It has the excitatory “fan-out tracks”, but not the specific inhibition. Clearly: Inhibition is computationally powerful and should be studied more!

Brain region models and papers Official: X | Linktree

Models of rodent hippocampus and somatosensory regions - and papers using them

linktr.ee
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Studying the #hippocampus? Our latest model is now hosted on hippocampushub.eu A versatile platform with extensive analysis tools and an interface to facilitate further research. Let us know your feedback! See also👉 lnkd.in/eQ6jaRjZ for papers, downloads etc.
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Our Somatosensory cortex and Hippocampus models are out! Why does it matter? Check out this brief article 👇 actu.epfl.ch/news/empowering… #Simulation #Neuroscience

Empowering Neuroscience: Large Open Brain Models Released

Scientists at EPFL’s Blue Brain Project, together with collaborators and contributors all over the world have developed the largest and most detailed computational models of rat hippocampal and...

actu.epfl.ch
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Delighted our general atlas-based open model of the somatosensory cortex inc. plasticity & EM connectivity is out in 3 @eLife papers. We used it to study emergent network-level plasticity, spike sorting, intra/inter-area coding, EEG/LFP and struc./function linktr.ee/BlueBrainPjt
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Want to know what the model is useful for? Check out the plasticity paper or any other publication using the model: LFP, EEG, assembly formation, structure-function… 👉 linktr.ee/BlueBrainPjt

Brain region models and papers Official: X | Linktree

Models of rodent hippocampus and somatosensory regions - and papers using them

linktr.ee
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...and this video on the impact of connectome complexity on activity. Let us know your feedback!
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