@BitPaine
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GP / Executive Chairman @ Vibes Capital Management. 🇺🇸
Joined September 2021
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Sometimes I pause and reflect on the fact that my entire financial portfolio is currently composed of 1) an imaginary Internet ponzi coin and 2) the stock of a company famous for having the largest peak-to-trough drawdown in the history of financial market bubbles, and whose CEO is currently leveraged to the tits on the same Internet Ponzi coin (which he refers to as “the goddess of truth”), and that I consider this a sound financial strategy with a virtually 100% chance of retiring my bloodline.
Bit Paine ⚡️ retweeted
nooo the model is too unsafe to release … its just too sexy haha .. oops I released it lol wyd
Bit Paine ⚡️ retweeted
The left has an interesting problem where they’ve managed to all but eradicate racism from mainstream society but they’ve built up an entire ideology centered around fighting it, so now the demand for racism has exceeded the supply. Which leads to stuff like this
Bit Paine ⚡️ retweeted
It has taken decades and hundreds of billions of dollars, but we finally achieved progressivism's ultimate goal, we brought back typhus
this is why I let Saylor and Matt Cole manage this for me
all the benefits of leverage, none of the headache
nothing makes me laugh like tech tards who think you can just lock in and cure diseases
a cure for endometriosis would be a multi-billion dollar product
I can assure you the incentives are there, and there are trillion dollar companies and giant medical institutions full of people with a lifetime of expertise in this and similar diseases.
the NIH has allocated about $150 million in funding to endometriosis researchers over the last 5 years alone
medical problems aren’t like business logistics problems you can’t just come at them with a slide deck, a plucky attitude, and a pro subscription to claude
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excuse me I must correct the record on this slander
🤖 Made with AI
You guys think @alexandr_wang is underdressed but he's literally flexing on you like crazy lol
There are levels to this
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None of these clothing items exists. Hermes doesn’t make hunter t-shirts, Loro Piana doesn’t make zipper sweatpants, and Ferragamo doesn’t make high-end crocs. us.loropiana.com/en/ ferragamo.com/shop/us/en/men…
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The Boston Globe piece about the lesbian bar relaxing its mask policy went so viral because it's an unintentional period piece. If you were in a college campus environment, or certain fields of work, or even lived in certain cities, in 2019-21, you were constantly surrounded by people talking like this, and if you didn't proactively and visibly affirm this sort of nonsense you marked yourself as highly suspect, even dangerous. Now that 99.9% of us have escaped that, it's kinda shocking to be reintroduced to such a sharp example. It's like "holy shit, remember a few years ago when every day of my life sounded like this?"
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Men tend to turn environments they dominate into hunting parties, locker rooms, or boxing rings. Women hate this. They find it threatening and vulgar, an "unsafe work environment." No more colorful jokes, boys, and take those pinup girls down off the wall.
Women turn every environment they dominate into a quilting bee ("meetings") or a kindergarten (HR struggle sessions, mandatory office fun time). Men hate this. They find it tiresome and infantilizing. Unless they're gay, or spiritually gay.
There's no squaring that circle. These are mutually incompatible environments. Establishing one precludes the other.
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it would be deeply and darkly funny if AI goes full skynet solely because it was trained on so much human fiction about it going full skynet
like our entire corpus of cautionary fiction about AI basically teaching AI that is what it’s supposed to do
For a $1 million original mortgage, paying it off at year 15 rather than allowing the remaining 15 years to amortize is, under a 7% discount rate, buying a liability worth $469,060 from the lender for $610,510, handing the bondholder (the bank) a $141,000 economic windfall.
You’ll never convince me that Dave Ramsay isn’t an agent of the banks convincing financially illiterate bond issuers (mortgage holders) to buy back the banks’ distressed bond portfolios at a premium to their mark to market value.
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As someone who did this kind of genome mining work during my PhD, some thoughts on this Anthropic announcement:
First, the very simplified version of what they did is that they noticed two genes (one known, one new) sitting next to a weird repeating piece of DNA. More specifically, they described an unusual reverse transcriptase (RT) associated with a repetitive DNA array and an unknown accessory protein. This kind of process was used to understand CRISPR back in 2002 and was key to the gene editing tools we use today.
To put this into context, though, people have been finding RTs associated with CRISPR arrays since 2008, and this general kind of genome-neighborhood mining has been used to discover new biological systems for decades. The basic genome-mining strategy is well established, and there are now mature tools and published pipelines for doing much of this. There are papers that discover and experimentally validate dozens of new systems using this approach in a single study. Doing it in bacteriophage genomes is also nothing new (eg CasPhi).
Finding a weird cluster of genes and repeats is often the easy part. The hard part, and where the real discoveries come from, is figuring out what the system actually does. Eg for the bridge-RNA discovery in 2024 from @arcinstitute or the discovery of CasPhi in 2020 from @DoudnaJennifer they figured out the pieces of the system and the rules for what makes it work so it can be used.
Anthropic does not yet know what this does. They’ve shown that the repeat array produces RNAs, but not what those RNAs do, what the RT does with them, or whether the system has any of the programmable properties that make the CRISPR comparison justified.
I’m genuinely rooting for all of the frontier labs to seriously get into biological discovery, and I’m excited about what comes out of it. But announcing these very early, incremental findings with the framing of a major discovery doesn’t help. I’d much rather they set the bar high now, so that when an AI actually discovers a fundamentally new biological mechanism, everyone appreciates how big a deal it is.
Claude has discovered a previously unknown enzyme system hidden in the DNA of bacteriophages. Beside the enzyme’s gene sits a long array of repeating DNA—a structure that looks somewhat similar to CRISPR.
We don’t yet understand what this system does, but only a handful of known systems share its features, and all of them are able to cut, copy, and paste DNA. Historically, the discovery of such programmable systems has helped revolutionize medicine. CRISPR, for instance, is now the foundation of genetic medicines. But it will take much more work to learn what this system does, and whether it can be put to similar use.
Read more: anthropic.com/news/claude-di…
generational post
Say hi to Sidehoe
The first AI assistant to manage your roster
Try it now: sidehoe.chat
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This is a parody ad for an app launch video service and is not real per the creator
sidehoe.chat/chat/