@BiocatTUD
Joined November 2018
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DERA-Catalyzed Chemoenzymatic Access to Nucleobase-Substituted Candidate Statin Precursors; R. Fernández Varela, E. Abdelraheem, L. Giaimo, L. Cortés, L. Lafuente, A. Laura Valino, P. Hagedoorn, U. Hanefeld, A. Iribarren & E. Lewkowicz
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#deoxyribose5phosphate #aldolase #DERA #Pectobacterium #atrosepticum #aldoladdition #statins #nucleobases doi.org/10.3390/biom16020321

DERA-Catalyzed Chemoenzymatic Access to Nucleobase-Substituted Candidate Statin Precursors

Aldolases are powerful biocatalysts for the stereoselective formation of carbon–carbon bonds and are widely used in the synthesis of chiral intermediates for pharmaceutical applications. Among them,...

mdpi.com
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Hydrated CO2-mediated redox chemistry for biophotoelectrocatalytic oxyfunctionalization of C–H bonds; . Hyun Kim, C. Hyeon Lee, M. Lee, D. Oh, Y. Hong, H. Yu, W. Jung, F. Hollmann & C. Beum Park #Biophotoelectrocatalysis #photoelectrocatalysis. nature.com/articles/s44160-0…
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Fallen-leaf-sensitized biosolar oxygenation of hydrocarbons; M. Lee, J. Jang, J. Cha, S. Hyun Lee, F. Hollmann, K. Won & C. Beum Park #Lignocellulose #solarpower #biocatalysis #peroxygenase doi.org/10.1039/D5GC04630K
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tudelft.nl/en/2026/tnw/resea…

Researchers discover new property of enzymes

tudelft.nl
Biocatalysis@TUDelft@BiocatTUDFeb 11
Engineered alcohol oxidases catalyse transesterification in aqueous media without competing hydrolysis; B. Wu, Y. Ma, C. Feng, L.i Ren, @cdomestici Y. Wang, T. Hilberath, U. Hanefeld @EPidko F. Hollmann & Y. Wang
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Engineered alcohol oxidases catalyse transesterification in aqueous media without competing hydrolysis; B. Wu, Y. Ma, C. Feng, L.i Ren, @cdomestici Y. Wang, T. Hilberath, U. Hanefeld @EPidko F. Hollmann & Y. Wang
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#Transesterification #organicchemistry,#alcoholoxidase #biocatalysis doi.org/10.1038/s41467-026-6…

Engineered alcohol oxidases catalyse transesterification in aqueous media without competing...

Nature Communications - Transesterification reactions are essential in organic chemistry, however, performing these reactions in aqueous media is challenging due to the competing hydrolysis...

nature.com
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Computational rational design of unspecific peroxygenase for C-H oxidation; R. Gao, X. Fu, Z. Li, Z. Wang, G. Li, J. Ge, F. Hollman, Z. Wang, W-Y, Lou, X. Wu #rationaldesign #enzymes #oxidation #peroxygenases #biocatalysts doi.org/10.1126/sciadv.aeb63…

Computational rational design of unspecific peroxygenase for C-H oxidation

Computational design delivers CviUPO with 13-fold higher C–H oxidation activity and >99% ee.

science.org
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Updated group picture 27.01.2026
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MOF-constrained Rh enables stable in situ H2O2 supply for peroxide-dependent enzymes; Y. Wang, C. Huang, J. Albertsma @MAvanderVeen @MiguelAlcaldeG F. Hollmann #H2O2generation #Rhodium #FMN #reduction #Peroxygenase doi.org/10.1016/j.mcat.2026.…
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Maximized lipase-catalysed production of a monoester of ferulic acid derivatives and ethylene glycol: a key step toward intrinsically antioxidant biosourced polymers; F. D. Blanco, M. P. M. Geevers, U. Hanefeld, L. Chebil, C. Humeaua & Y. Guiavarc’h
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#Ferulicacid #biopolymers #lipase #dihydroferulicacid doi.org/10.1039/D5GC02821C
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Today we said goodbye to our group secretary @Irmazomerdijk you will be missed! You always had a kind word to say to everyone! Dankjewel en succes 🍀
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Enzymatic Synthesis of Enantiopure (R)-Citronellal from Geraniol via a Short-Chain Dehydrogenase and Ene Reductase; C. Ferrer-Carbonell, R. Villa, I. Viskaal, D. J. Opperman & @Caroline_E_Paul #biocatalysis #citral #OldYellowEnzymes doi.org/10.1002/adsc.2025000…
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Enantioselective synthesis of (R)-citronellal from geraniol with an immobilised copper alcohol oxidase and ene reductase; B. Tagliabue, C. M. Heckmann, R. Villa, S. Grisel @jgberrin M. Lafond, D. Ribeaucourt & @Caroline_E_Paul
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#Citronellal #chiral #menthol #terpenoid #cascade #enzyme doi.org/10.1039/D5RE00034C
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Asymmetric Enantio-complementary Synthesis of Thioethers via Ene-Reductase-Catalyzed C–C Bond Formation; C. M. Heckmann, D. J. Heyes @Martinpabst E. Otten, N. S. Scrutton @Caroline_E_Paul #EnantioselectiveSynthesis #Proteins #flavins #bindingmodes pubs.acs.org/doi/10.1021/jac…

Asymmetric Enantio-complementary Synthesis of Thioethers via Ene-Reductase-Catalyzed C–C Bond...

Abstract. Enzymes are attractive catalysts due to their high chemo-, regio-, and enantioselectivity. In recent years, the application of enzymes in organic

pubs.acs.org
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A. Pothuizen, R. I. Wouters, H. Brasselet, T. Hilberath, Y. Wu & F. Hollmann; From characterization to biocatalytic application of two peroxygenases from Collariella virescens and Daldinia caldariorum #Peroxygenase #Oxidation #Epoxidation doi.org/10.5802/crchim.375
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Biocatalysis@TUDelft retweeted
J. Am. Chem. Soc.@J_A_C_S4 Jun 2025
On the cover of this week's issue: "Asymmetric Enantio-complementary Synthesis of Thioethers via Ene-Reductase-Catalyzed C–C Bond Formation" Read it here 🔗 go.acs.org/cGe
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Congratulations to @allisonwolder on her successful PhD defense. Also congrats to promoter Prof. Frank Hollman and co-promoter @Caroline_E_Paul . Congratulations also to her husband and two sons and family from Canada!
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