I do benchformatics (bad at the bench, bad at the bioinformatics) at Evodynamics Lab (IRYCIS) - Madrid
Joined May 2023
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What if multireplicon plasmids are not an oddity, but an evolutionary strategy?
We found that they are common, more mobile, broader-host-range, and enriched in AMR.
Even more interesting: their assembly doesn’t look random. 👀
Preprint: biorxiv.org/content/10.64898…
See below!🧵👇
5/5. The molecular scars are still visible. Fusion breakpoints show signatures of homologous recombination and insertion sequences, especially IS6-family elements. Many duplicated ISs are inverted, which may help lock fused plasmids in place! ⛓️
Big shoutout to my coauthors and everyone involved in this work! Thank you!🥳
@Jero_RB @paula_micro @valflanza @Cris_Herencias @JGamma3
Ignacio (Nacho) de Quinto retweeted
New paper out in PNAS!!! 🎉
Do more plasmid copies mean faster evolution?
🧵 Dive into the story
pnas.org/doi/10.1073/pnas.25…
Ignacio (Nacho) de Quinto retweeted
🚨🚨New paper out!!!
Come for the first large-scale analysis of plasmid copy number across species,
stay for one of the most intriguing results of my lab: universal scaling laws in plasmid biology! 📈🧬
👉nature.com/articles/s41467-0…
Do you use 96 (or 384) well plates in your lab?🔬
I've put up a super simple (and free) to use APP to streamline experiment design and result analysis of these experiments for my lab pals.
You can try it here: rosettier.streamlit.app/
Feedback is very welcome 😁!
Ignacio (Nacho) de Quinto retweeted
Orgulloso y feliz de recibir el Premio de Investigación Margarita Salas de la CAM.
Es el segundo premio en dos semanas ¡un verdadero reconocimiento al trabajo que hacemos en el labo!
Gracias a mis mentores, compañeros y colaboradores ¡este premio es de todos!
¡Seguimos! 🍾🥂🎉
🔬 La @comunidadmadrid ha concedido los Premios de Investigación Margarita Salas, Miguel Catalán y Julián Marías 2024, que reconocen las trayectorias profesionales de los investigadores de la región
📚 La relación de ganadores se ha publicado en el BOCM
c.madrid/1ztu31
Ignacio (Nacho) de Quinto retweeted
Profundamente emocionado, orgulloso y contento de recibir el Premio Nacional de Investigación en Biología “Margarita Salas” de @CienciaGob.
A lo largo de estos años he tenido el privilegio de aprender, trabajar y disfrutar con los mejores. El premio es tan suyo como mío.
✅ El Ministerio de @CienciaGob concede los Premios Nacionales de Investigación 2024.
🗣️@DianaMorantR: "Son el reconocimiento más importante de España en el ámbito de la investigación científica y es la edición con mayor número de mujeres premiadas".
👉🏻ciencia.gob.es/Noticias/2024…
Ignacio (Nacho) de Quinto retweeted
Humbled and honoured to receive the “Margarita Salas” National Research Award from @CienciaGob.
The award belongs to my stellar mentors, collaborators, coworkers, and lab members. They are the giants' shoulders on which I stand every day.
Now, let's open the champagne!! 🍾🕺
✅ El Ministerio de @CienciaGob concede los Premios Nacionales de Investigación 2024.
🗣️@DianaMorantR: "Son el reconocimiento más importante de España en el ámbito de la investigación científica y es la edición con mayor número de mujeres premiadas".
👉🏻ciencia.gob.es/Noticias/2024…
Ignacio (Nacho) de Quinto retweeted
Quite excited about the latest "Universal rules govern plasmid copy number", with my new group: @paula_micro @BioNacho & @Jero_RB !
Have you given it a look yet?
Check also the supporting work by @lingchongyou & Co.
Ignacio (Nacho) de Quinto retweeted
Fantastic work by @paula_micro ! Don't miss her findings on how plasmids keep count'! Congrats to all the co-authors @BioNacho, @JGamma3, and @Jero_RB !!
Ignacio (Nacho) de Quinto retweeted
Check out our new work to read about one of the most surprising (and amazing) results of my career:
Plasmids are governed by a universal scaling law that links copy number and size across phylogenetic boundaries.
A real tour de force by @paula_micro, @BioNacho and @JGamma3!
👇
Ignacio (Nacho) de Quinto retweeted
Universal rules govern plasmid copy number biorxiv.org/cgi/content/shor… #biorxiv_micrbio
Ignacio (Nacho) de Quinto retweeted
Interested in plasmid biology? Our new preprint is now available!!! 🚨
In this work, we analyzed thousands of diverse bacterial plasmids to characterize for the first time one of the most fundamental aspects of plasmid biology: Plasmid copy number. 1/7 👇
Universal rules govern plasmid copy number biorxiv.org/cgi/content/shor… #biorxiv_micrbio
Ignacio (Nacho) de Quinto retweeted
Todo listo para la #NocheEuropeaInvestigadores 🧪🌚
Os esperamos mañana 27/09 de 17:30 a 21:00 en nuestro stand "luchando contra la resistencia a antibióticos" y el taller "siendo microbiólog@ por un día" (18:30)✋🏼🦠
📍CaixaForum Madrid
No os lo podéis perder!🧬✨
It's almost impossible to write in these few words how amazing of an experience this has been. My first oral presentation at my first international congress, all this in Japan and surrounded by incredible people.
Truly thankful to everyone that made this possible. 🌸
#ISPB2024 – at Hamamatsu-shi Naka-ku, Shizuoka
