@BioIntelligeNet

Postdoc at Caltech; UCSD, U-DUB (UW) alumni

 Pasadena, CA
Joined November 2021
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Our paper is out in Nature, congrats to Qiyu, An et al! By stimulating ~20 motor cortex neurons carefully selected based on their activity, we could induce learned population activity and, sometimes, the movement itself, depending on the brain's state. nature.com/articles/s41586-0…

Targeted stimulation of motor cortex ensembles drives learned movements

Nature - Optogenetic stimulation of motor-cortex neuron ensembles shows that precisely timed activity in the primary motor cortex can generate learned neural patterns and movements, demonstrating...

nature.com
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1. CRISPR came from basic research on bacteria. 2. Optogenetics started with a discovery in algae. 3. The GFP protein comes from jellyfish. The biggest breakthroughs all trace to scientists follow their curiosity. This is one huge reason why we must keep funding basic research!
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Our new paper is out in Nature, congrats to Sonja et al.! An excellent collab with Irina Dudanova's group. We promoted neuroplasticity to improve behavior in a mouse model of a neurodegenerative disease. nature.com/articles/s41586-0…

Restoring cortical disinhibition improves Huntington’s disease phenotypes

Nature - In a mouse model of Huntington’s disease, targeted modulation of neuronal activity restores network function and improves motor deficits.

nature.com
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Our new paper is out in Current Biology! We learn many things in parallel, and brain circuits are constantly rewiring across brain areas. It is notoriously difficult to understand which rewiring events are responsible for which type of learning. sciencedirect.com/science/ar…
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Our new paper is out in Neuron! cell.com/neuron/fulltext/S08… How does the brain decide how much of the past to use when making decisions? In rapidly changing environments, recent experiences matter more; in stable environments, longer histories are useful.
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Online now: Adaptive reorganization of history encoding in the retrosplenial cortex supports flexible decision-making strategies dlvr.it/TSdfV9
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Our new work is out in Science Advances. We show that neural activity in the striatum reflects not just cortical inputs, but also often-underappreciated thalamic inputs. science.org/doi/10.1126/scia…

Complementary cortical and thalamic contributions to cell type–specific striatal activity dynamics...

Cell type–specific striatal activity during movement is shaped by cortical and thalamic inputs with complementary roles.

science.org
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Excited to share our new preprint on olfactory bulb dynamics 🎉! Huge thanks to @AlexKoulakov @navlakha_lab and to our collaborator Bin @BioIntelligeNet 👉🏼 biorxiv.org/content/10.64898… to read more about adaptation, representational drift, and odor manifolds 🔵🔴
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🧵1/ Excited to share our new paper: "Brain Region-Specific Epigenomic Reorganization and Altered Cell States in Alzheimer’s Disease" We built a single-cell multi-omic atlas (DNA methylation + 3D genome) from AD and control brains. Paper: biorxiv.org/content/10.1101/…

Brain Region-Specific Epigenomic Reorganization and Altered Cell States in Alzheimer’s Disease

Alzheimer’s disease (AD) is the most common neurodegenerative disorder, yet the molecular mechanisms underlying its region- and cell-type-specific pathogenesis remain poorly defined. Here, we...

biorxiv.org
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Excited to share that the main part of my PhD thesis is now published in @ScienceMagazine! I am grateful for my amazing mentor’s @takaki_komiyama guidance and the contributions of all co-authors!
Takaki Komiyama@takaki_komiyama20 Jun 2025
Our new paper is out in Science. We identified a subgroup of cholinergic neurons that mediate sensory modality-specific attention. They change their funcitonal properties within secs of behavioral context change. Congrats to Bin and the team! science.org/doi/10.1126/scie…

Cholinergic feedback for modality- and context-specific modulation of sensory representations

The brain’s ability to prioritize sensory information is crucial for adaptive behavior, yet its mechanisms remain unclear. We investigated basal forebrain cholinergic neurons modulating olfactory...

science.org
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Today in @ScienceMagazine: How do our brains bring our attention on one sense over another? UC San Diego researchers have discovered the group of neurons responsible, with implications for various health disorders and AI research.science.org/doi/10.1126/scie…
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Replying to @alexbchen
Congrats!
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Thrilled to share my postdoc work from @takaki_komiyama lab, showing how motor learning reshapes thalamic influence on motor cortex to enable learned movements. Hats off to our collaborators and co-authors for their incredible contributions! nature.com/articles/s41586-0…

Motor learning refines thalamic influence on motor cortex

Nature - Imaging and optogenetics in mice provide insight into the interplay between the primary motor cortex and the motor thalamus during learning, showing that thalamic inputs have a key role in...

nature.com
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Our new paper is out in Science. What is the synaptic plasticity rule in the brain, we asked. It turns out there are multiple, even within individual neurons. Congrats Jake! science.org/doi/10.1126/scie…

Distinct synaptic plasticity rules operate across dendritic compartments in vivo during learning

Synaptic plasticity underlies learning by modifying specific synaptic inputs to reshape neural activity and behavior. However, the rules governing which synapses will undergo different forms of...

science.org
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New paper led by @S_Blumenstock shows that targeted stimulation of a subtype of cortical inhibitory neurons can ameliorate motor deficits in Huntington’s disease mice. A great collab with @IrinaDudanova biorxiv.org/content/10.1101/…

Optogenetic restoration of neuron subtype-specific cortical activity ameliorates motor deficits in...

Huntington’s disease (HD) is a devastating movement disorder without a current cure. Although the monogenic basis of HD is well-defined, the complex downstream effects that underlie behavioral...

biorxiv.org
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663 days since the senseless tragedy that took An, we present a manuscript that reports some of the discoveries that she left us. biorxiv.org/content/10.1101/…

Targeted stimulation of motor cortex neural ensembles drives learned movements

During the execution of learned motor skills, the neural population in the layer 2/3 (L2/3) of the primary motor cortex (M1) expresses a reproducible spatiotemporal activity pattern. It is debated...

biorxiv.org
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University of Washington biochemist David Baker has won the 2024 Nobel Prize in Chemistry for his pioneering work designing new proteins that can neutralize viruses, target cancer cells, and more. Read more from @uwmedicine: go.uw.edu/2024NobelPrize #NobelPrize #GoHuskies
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BREAKING NEWS The Royal Swedish Academy of Sciences has decided to award the 2024 #NobelPrize in Physics to John J. Hopfield and Geoffrey E. Hinton “for foundational discoveries and inventions that enable machine learning with artificial neural networks.”
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Come say hi to us in Chicago! #sfn2024
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I am excited to announce that a part of my thesis work with @takaki_komiyama is out on bioRxiv! Summary 🧵⬇️. Thanks to all the co-authors' contributions!
Takaki Komiyama@takaki_komiyama15 Sep 2024
Our new paper by @BioIntelligeNet showing that olfactory bulb-projecting cholinergic neurons enhance odor representations in a context- and modality-specific manner biorxiv.org/content/10.1101/…

Cholinergic feedback for context-specific modulation of sensory representations

The brain’s ability to prioritize behaviorally relevant sensory information is crucial for adaptive behavior, yet the underlying mechanisms remain unclear. Here, we investigated the role of basal...

biorxiv.org
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