SynBioGPT2 combines hybrid retrieval, iterative self-evaluation and expert prompts for microbial cell-factory design, reconstructing 86/92 expert-curated metabolic-engineering strategies. #BioDesignResearch #SyntheticBiology #AI DOI: doi.org/10.1016/j.bidere.202…

Can extremophile archaea help tackle persistent plastics? This review examines archaeal bioremediation of polyolefins and polyesters in extreme environments. #BioDesignResearch #Bioremediation #Archaea DOI: doi.org/10.1016/j.bidere.202…

A cellulose-based simultaneous saccharification and fermentation strategy manages glucose supply to ease carbon catabolite repression of xylose and improve engineered E. coli production of 1,2,4-butanetriol. #BioDesignResearch #MetabolicEngineering DOI: doi.org/10.1016/j.bidere.202…

Prime editing is moving beyond single-base changes. This review covers molecular innovations, large-fragment genome engineering and AI-guided design for more programmable genome rewriting. #BioDesignResearch #PrimeEditing #GenomeEngineering Details: sciencedirect.com/science/ar…

Sustainable chemical technology needs decisions beyond reaction chemistry. This article links material, process, system and life-cycle perspectives with practical assessment approaches. #BioDesignResearch #GreenChemistry #Sustainability Details: sciencedirect.com/science/ar…

Adaptive evolution and transcriptomics reveal formic-acid stress responses in Saccharomyces cerevisiae, supporting more robust yeast for microbial-electrocatalytic bioproduction. #BioDesignResearch #YeastEngineering #Biomanufacturing Details: sciencedirect.com/science/ar…

Rumen microbes are natural lignocellulose specialists. This review maps their degradation mechanisms and metabolic routes toward high-value chemical production. #BioDesignResearch #Lignocellulose #MicrobialBiotechnology Details: sciencedirect.com/science/ar…

Pine engineering needs genome-aware design. This Perspective uses recent chromosome-scale assemblies to frame how conifer genome architecture can guide hypothesis-driven genome engineering. #BioDesignResearch #PlantGenomics #GenomeEngineering Details:sciencedirect.com/science/ar…

Engineered yeast enables de novo medicarpin biosynthesis for sustainable phytoalexin production #Medicarpin #YeastEngineering #NaturalProducts Details: doi.org/10.1016/j.bidere.202…

A metabolic buffer improves growth of 1-butanol-producing E. coli and strengthens microbial C4 alcohol bioproduction #1Butanol #MetabolicEngineering #MicrobialCellFactory Details: doi.org/10.1016/j.bidere.202…

AI models are reshaping enzyme engineering from machine learning to multimodal design systems #EnzymeEngineering #MachineLearning #ProteinDesign Details: doi.org/10.1016/j.bidere.202…

Luminescence-based tracing technologies are reviewed for tracking biological processes across scale #Bioimaging #LuminescenceTracing #BiodesignTools Details: doi.org/10.1016/j.bidere.202…

Microbial-type terpene synthases introduce new plant defense chemistry against insects and fungal pathogens #TerpeneSynthase #PlantDefense #SyntheticBiology Details: doi.org/10.1016/j.bidere.202…

RecN emerges as a tunable switch coordinating DNA repair choice and stress-resilience programs #DNARepair #StressResponse #GenomeEngineering Details: doi.org/10.1016/j.bidere.202…

Heptad insertion expands E. coli ROP protein length by 50%, probing modular rules of protein architecture #ProteinDesign #HeptadRepeat #ProteinEngineering Details: doi.org/10.1016/j.bidere.202…

Komagataella phaffii is established as a cell factory for efficient chondroitin sulfate production #ChondroitinSulfate #CellFactory #Glycoengineering Details: doi.org/10.1016/j.bidere.202…

A metabolic buffer improves growth of 1-butanol-producing E. coli and strengthens microbial C4 alcohol bioproduction #1Butanol #MetabolicEngineering #MicrobialCellFactory Details: doi.org/10.1016/j.bidere.202…

Microbial-type terpene synthases introduce new plant defense chemistry against insects and fungal pathogens #TerpeneSynthase #PlantDefense #SyntheticBiology Details: doi.org/10.1016/j.bidere.202…

RecN emerges as a tunable switch coordinating DNA repair choice and stress-resilience programs #DNARepair #StressResponse #GenomeEngineering Details: doi.org/10.1016/j.bidere.202…

Machine learning links fermentation design with process optimization for efficient bioproduction #FermentationDesign #MachineLearning #Bioprocessing Details: doi.org/10.1016/j.bidere.202…